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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cfpd</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень физиологии и патологии дыхания</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin Physiology and Pathology of Respiration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5029</issn><publisher><publisher-name>Дальневосточный научный центр физиологии и патологии дыхания</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36604/1998-5029-2022-83-81-90</article-id><article-id custom-type="elpub" pub-id-type="custom">cfpd-1007</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SELECTED REPORTS</subject></subj-group></article-categories><title-group><article-title>Меланома с поражением органов дыхания</article-title><trans-title-group xml:lang="en"><trans-title>Melanoma with respiratory damage</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григоренко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigorenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Александрович Григоренко, д-р мед. наук, профессор, зав. лабораторией</p><p>морфологическая лаборатория</p><p>675000</p><p>ул. Октябрьская, 110</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Aleksey A. Grigorenko, MD, PhD, DSc (Med.), Professor, Head of Department</p><p>Department of Morphology</p><p>675000</p><p>110 Oktyabrʹskaya Str.</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">gvg069@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Войцеховский</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Voytsekhovskiy</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валерий Владимирович Войцеховский, д-р мед. наук, доцент, зав. кафедрой</p><p>Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия»</p><p>кафедра госпитальной терапии с курсом фармакологии</p><p>675000</p><p>ул. Горького, 95</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Valeriy V. Voytsekhovskiy, MD, PhD, DSc (Med.), Associate Professor, Head of Department</p><p>Department of Hospital Therapy with Pharmacology Course</p><p>675000</p><p>95 Gor'kogo Str.</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">voitsehovsckij@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рощин</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Roshchin</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Николаевич Рощин, канд. мед. наук, врач</p><p>морфологическая лаборатория</p><p>675000</p><p>ул. Октябрьская, 110</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Sergey N. Roshchin, MD, PhD (Med.), Morphologist</p><p>Department of Morphology</p><p>675000</p><p>110 Oktyabrʹskaya Str.</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">serzrosa@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филатова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Filatova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Александровна Филатова, канд. мед. наук, врач-гематолог</p><p>гематологическое отделение</p><p>675028</p><p>ул. Воронкова, 26</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Ekaterina A. Filatova, MD, PhD (Med.), Hematologist</p><p>Department of Hematology</p><p>675028</p><p>26 Voronkova Str.</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">ekaterina.gladun.86@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Государственное бюджетное учреждение здравоохранения Амурской области «Амурский областной онкологический диспансер»<country>Россия</country></aff><aff xml:lang="en">Amur Regional Oncology Dispensary<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Amur State Medical Academy<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Государственное автономное учреждение здравоохранения Амурской области «Амурская областная клиническая больница»<country>Россия</country></aff><aff xml:lang="en">Amur Regional Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>23</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>83</issue><fpage>81</fpage><lpage>90</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Григоренко А.А., Войцеховский В.В., Рощин С.Н., Филатова Е.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Григоренко А.А., Войцеховский В.В., Рощин С.Н., Филатова Е.А.</copyright-holder><copyright-holder xml:lang="en">Grigorenko A.A., Voytsekhovskiy V.V., Roshchin S.N., Filatova E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cfpd.elpub.ru/jour/article/view/1007">https://cfpd.elpub.ru/jour/article/view/1007</self-uri><abstract><sec><title>   Цель</title><p>   Цель. Демонстрация случаев меланомы редкой локализации – с поражением органов дыхания.   Материалы и методы. Представлен краткий обзор литературы по меланомам некожных локализаций; особое внимание уделено меланомам дыхательных путей и легких, первичной локализации и метастатическому поражению. Приведены клинические наблюдения данной патологии.</p></sec><sec><title>   Результаты</title><p>   Результаты. В работе представлены два редких случая из личной практики авторов: диагностики первичной меланомы придаточных пазух носа с прорастанием основания черепа, и метастатического поражения легкого, при котором были сложности определения первичной локализации опухоли. В обоих случаях проводилась дифференциальная диагностика с другими образованиями соответствующих областей. Окончательный диагноз установлен при помощи гистологического и иммуногистохимического исследований.</p></sec><sec><title>   Заключение</title><p>   Заключение. Диагноз меланомы с поражением органов дыхания требует дифференциальной диагностики с другими образованиями данной локализации. Окончательный диагноз помогают установить гистологическое и иммуногистохимическое исследования.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   Aim</title><p>   Aim. Demonstration of cases of melanoma of rare localization – with damage to the respiratory system.   Materials and methods. A brief review of the literature on non-skin melanomas is presented; special attention is paid to melanomas of airways and lungs, primary localization and metastatic lesions. Clinical observations of this pathology are given.</p></sec><sec><title>   Results</title><p>   Results. The paper presents two rare cases from the personal practice of the authors: the diagnosis of primary melanoma of the paranasal sinuses with germination of the base of the skull and metastatic lung damage, in which it was difficult to determine the primary localization of the tumor. In both cases, differential diagnosis was carried out with other formations in the respective areas. The final diagnosis was made by histological and immunohistochemical studies.</p></sec><sec><title>   Conclusion</title><p>   Conclusion. The diagnosis of melanoma with damage to the respiratory organs requires differential diagnosis with other formations of this localization. A histological and immunohistochemical study helps to establish the final diagnosis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>меланома</kwd><kwd>меланомы дыхательных путей и легких</kwd><kwd>меланома придаточных пазух носа</kwd><kwd>метастаз меланомы в легкое</kwd></kwd-group><kwd-group xml:lang="en"><kwd>melanoma</kwd><kwd>melanomas of the airways and lungs</kwd><kwd>melanomas of the paranasal sinuses</kwd><kwd>lung metastasis of melanoma</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование проводилось без участия спонсоров</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>This study was not sponsored</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Меланома кожи и слизистых оболочек: Клинические рекомендации. – 2018. – 94 с. 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