cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2022-84-49-62cfpd-1021Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHДиагностика лёгочного саркоидоза методом компьютерно-томографической денситоволюметрии.Diagnostics of pulmonary sarcoidosis by the method of computed tomographic densitovolumetryИгнатьеваЕ. А.Ignat’evaE. A.

Елена Александровна Игнатьева, аспирант, лаборатория функциональных методов исследования дыхательной системы, врач-рентгенолог

675000, г. Благовещенск, ул. Калинина, 22

Elena A. Ignat’eva, MD, Postgraduate Student of the Laboratory of Functional Research of Respiratory System, Roentgenologist

22 Kalinina Str., Blagoveshchensk, 675000, Russian Federation

ignatyevalena6618@gmail.comИльинА. В.Il’inA. V.

Андрей Валерьевич Ильин, канд. мед. наук, зав. отделением лучевой диагностики, врач-рентгенолог

675000, г. Благовещенск, ул. Калинина, 22

Andrey V. Il’in, MD, PhD (Med.), Roentgenologist, Head of Department of X-Ray Diagnostics

22 Kalinina Str., Blagoveshchensk, 675000, Russian Federation

alero82@yandex.ruПерельманЮ. М.PerelmanJ. M.

Юлий Михайлович Перельман, член-корреспондент РАН, д-р мед. наук, профессор, зам. директора по научной работе, зав. лабораторией функциональных методов исследования дыхательной системы

675000, г. Благовещенск, ул. Калинина, 22

Juliy M. Perelman, MD, PhD, DSc (Med.), Corresponding member of RAS, Рrofessor, Deputy Director on Scientific Work, Head of Laboratory of Functional Research of Respiratory System

22 Kalinina Str., Blagoveshchensk, 675000, Russian Federation

jperelman@mail.ruФедеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания»Far Eastern Scientific Center of Physiology and Pathology of Respiration2022090720220844962Copyright © Игнатьева Е.А., Ильин А.В., Перельман Ю.М., 20222022Игнатьева Е.А., Ильин А.В., Перельман Ю.М.Ignat’eva E.A., Il’in A.V., Perelman J.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1021Цель

Цель. Разработать новый метод количественной оценки цифровых данных КТ-изображений органов грудной клетки пациентов с саркоидозом, оценить диагностическую значимость полученных количественных показателей в сравнении с функциональными лёгочными тестами.

Материалы и методы

Материалы и методы. Обследованы здоровые лица (n=21) и больные легочным саркоидозом (n=101), разделенных на 5 групп в соответствии с классификацией J.G.Scadding. Функцию внешнего дыхания оценивали по данным спирометрии форсированного выдоха, бодиплетизмографии и исследования диффузионной способности легких. Всем обследованным выполнена двухэтапная компьютерная томография легких в инспираторную и экспираторную фазы с измерением параметров в 3 диапазонах плотности.

Результаты

Результаты. Значения полученных количественных показателей, определённые новым методом КТ-денситоволюметрии, отличались от группы контроля как в общей группе больных саркоидозом, так и отдельных группах по классификации J.G.Scadding. Обнаружены корреляционные связи между радиометрическими измерениями и показателями функции лёгких. У пациентов с саркоидозом определялся больший объём плохо вентилируемых отделов, чем в группе здоровых.

Заключение

Заключение. Новый метод КТ-денситоволюметрии позволяет количественно оценить весь объём лёгочной ткани в области томографического покрытия, полученные результаты могут быть использованы в качестве полезного инструмента в прогнозировании течения заболевания и ответа на проводимую терапию.

Aim

Aim. To develop a new method for quantitative evaluation of digital data of chest CT images of patients with sarcoidosis, to evaluate the diagnostic significance of the obtained quantitative indicators in comparison with functional pulmonary tests.

Materials and methods

Materials and methods. Healthy individuals (n=21) and patients with pulmonary sarcoidosis (n=101), divided into 5 groups according to J.G.Scadding classification, were examined. The lung function was assessed according to the data of spirometry, body plethysmography and the study of the lung diffusion capacity. All examined patients underwent a two-stage computed tomography of the lungs in the inspiratory and expiratory phases with the measurement in 3 density ranges.

Results

Results. The values of the obtained quantitative indicators, determined by the new method of CT-densitovolumetry, differed from the control group both in the general group of patients with sarcoidosis and in individual groups according to the J.G.Scadding classification. Correlations were found between radiometric measurements and lung function parameters. In patients with sarcoidosis, a larger volume of poorly ventilated sections was determined in comparison with the healthy group.

Conclusion

Conclusion. The new method of CT-densitovolumetry makes it possible to quantify the entire volume of lung tissue in the area of tomographic coverage, the obtained results can be used as a useful tool in predicting the course of the disease and the response to ongoing therapy.

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The authors declare that there are no conflicts of interest present.