cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2022-84-116-126cfpd-1028Research ArticleОБЗОРЫREVIEWSФункциональное состояние митохондрий при хронических респираторных заболеванияхFunctional state of mitochondria in chronic respiratory diseasesКондратьеваЕ. В.KondratyevaE. V.

Елена Викторовна Кондратьева, канд. биол. наук, научный сотрудник, лаборатория медицинской экологии и рекреационных ресурсов

690105, г. Владивосток, ул. Русская, 73г

Elena V. Kondratyeva, PhD (Biol.), Staff Scientist, Laboratory of Medical Ecology and Recreational Resources

73g Russkaya Str., Vladivostok, 690105, Russian Federation

elena.v.kondratyeva@yandex.ruhttps://orcid.org/0000-0002-1009-9011ВиткинаТ. И.VitkinaT. I.

Татьяна Исааковна Виткина, д-р биол. наук, профессор РАН, зав. лабораторией медицинской экологии и рекреационных ресурсов

690105, г. Владивосток, ул. Русская, 73г

Tatiana I. Vitkina, PhD, DSc (Biol.), Professor of RAS, Head of Laboratory of Medical Ecology and Recreational Resources

73g Russkaya Str., Vladivostok, 690105, Russian Federation

tash30@mail.ruВладивостокский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт медицинской климатологии и восстановительного леченияVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Medical Climatology and Rehabilitative Treatment202209072022084116126Copyright © Кондратьева Е.В., Виткина Т.И., 20222022Кондратьева Е.В., Виткина Т.И.Kondratyeva E.V., Vitkina T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1028Введение

Введение. Хронические респираторные заболевания относятся к одним из наиболее распространенных типов неинфекционных заболеваний и являются важной проблемой современности. Индукция процессов окислительного стресса, хронического воспаления и гипоксии, которые лежат в основе патогенеза хронических заболеваний бронхолегочной системы, на клеточно-молекулярном уровне может быть детерминирована нарушением функционирования митохондрий.

Цель

Цель. Настоящий обзор посвящен перспективам оценки функционального состояния митохондрий, как чувствительного показателя течения хронических респираторных заболеваний. Результаты. Проанализированы данные отечественных и зарубежных источников о важнейших параметрах функционирования митохондрий в норме и при хронической бронхолегочной патологии. Показано, что митохондрии проявляют высокую чувствительность к изменению как экзо-, так и эндогенного гомеостаза. Функциональные параметры митохондрий, уровень митохондриальных активных форм кислорода, митохондриальный мембранный потенциал и жирнокислотный состав мембран митохондрий могут быть использованы как диагностические и прогностические критерии при хронических респираторных заболеваниях. Данные, представленные в обзоре, свидетельствуют о необходимости проведения дальнейших исследований функционального состояния митохондрий при хронической бронхолегочной патологии.

Introduction

Introduction. Chronic respiratory diseases are one of the most common types of non-communicable diseases and are an important problem of our time. The induction of oxidative stress, chronic inflammation and hypoxia, which underlie the pathogenesis of chronic diseases of the bronchopulmonary system, can be determined at the cellular and molecular level by impaired mitochondrial functioning.

Aim

Aim. This review is devoted to the prospects for assessing the functional state of mitochondria as a fine indicator of the course of chronic respiratory diseases.

Results

Results. The data of domestic and foreign sources on the most important parameters of mitochondrial functioning in normal and chronic bronchopulmonary pathology were analyzed. It has been shown that mitochondria are highly sensitive to changes in both exogenous and endogenous homeostasis. Functional parameters of mitochondria, the level of mitochondrial reactive oxygen species, mitochondrial membrane potential, and fatty acid composition of mitochondrial membranes can be used as diagnostic and prognostic criteria for chronic respiratory diseases. The data presented in the review indicate the need for further studies of the functional state of mitochondria in chronic bronchopulmonary pathology.

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The authors declare that there are no conflicts of interest present.