cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2022-84-127-136cfpd-1029Research ArticleОБЗОРЫREVIEWSЗакономерности развития сердечно-сосудистых нарушений у больных COVID-19 (краткий обзор литературы)Patterns of development of cardiovascular disorders in patients with COVID-19 (brief review)ШульгаА. С.ShulgaA. S.

Андрей Сергеевич Шульга, аспирант, кафедра госпитальной хирургии с курсом детской хирургии

675000, г. Благовещенск, ул. Горького, 95

Andrey S. Shulga, Postgraduate Student, Department of Hospital Surgery with a Pediatric Surgery Course

95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation

mig2994@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия» Министерства здравоохранения Российской̆ ФедерацииAmur State Medical Academy202209072022084127136Copyright © Шульга А.С., 20222022Шульга А.С.Shulga A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1029Введение

Введение. Сердечно-сосудистые заболевания остаются ведущей причиной смерти, как в России, так и в большинстве других стран, а проблема сердечно-сосудистых нарушений у больных COVID-19 является в настоящее время чрезвычайно актуальной.

Цель

Цель. Обобщить литературные данные о закономерностях развития сердечно-сосудистых нарушений у больных COVID-19.

Результаты

Результаты. В статье представлен обзор литературы базы данных PubMed и Google Scholar о закономерностях развития сердечно-сосудистых нарушений у больных COVID- 19. Показана патогенетическая связь вирусного шипового S-белка c ангиотензинпревращающим ферментом 2 в механизмах регуляции сердечно-сосудистой и иммунной системы. Определена роль провоспалительных цитокинов в формировании воспаления и фиброза при сердечно-сосудистой патологии. Продемонстрированы изменения сердечно-сосудистой системы на фоне COVID-19. Описаны основные принципы взаимодействия вируса SARSCoV-2 с эндотелиоцитами и кардиомиоцитами, механизмы воспалительных реакций, лежащие в основе развития сердечно-сосудистой патологии при COVID-19.

Заключение

Заключение. Анализ современных данных, касающийся повреждения сердечно-сосудистой системы при COVID-19, позволил сделать заключение о том, что, несмотря на значительные достижения в данной области исследований, многие аспекты до конца неясны и требуют дальнейшего изучения. Практическая значимость данного обзора определяется в идентификации потенциальных терапевтических мишеней для профилактики осложнений при COVID-19, а также расширении возможностей диагностирования SARS-CoV-2. Возможно, решающее значение для уменьшения осложнений, а также связанной с ней смертностью, имеет разработка эффективного метода для модуляции иммунного ответа.

Introduction

Introduction. Cardiovascular diseases remain the leading cause of death, both in Russia and in most other countries, and the problem of cardiovascular disorders in patients with COVID-19 is currently extremely important.

Aim

Aim. To summarize the literature data on patterns of development of cardiovascular disorders in patients with COVID-19.

Results

Results. The article presents a literature review of the PubMed and Google Scholar databases on the patterns of development of cardiovascular disorders in patients with COVID-19. The pathogenetic relationship of the viral spike S-protein with angiotensin-converting enzyme 2 in the mechanisms of regulation of the cardiovascular and immune systems was shown. The role of pro-inflammatory cytokines in the formation of inflammation and fibrosis in cardiovascular pathology has been determined. The changes in the cardiovascular system against the background of COVID-19 were demonstrated. The basic principles of the interaction of the SARS-CoV-2 virus with endotheliocytes and cardiomyocytes, the mechanisms of inflammatory reactions that underlie the development of cardiovascular pathology in COVID-19 are described.

Conclusion

Conclusion. An analysis of current data regarding damage to the cardiovascular system in COVID-19 led to the conclusion that, despite considerable achievements in this field of research, many aspects are not fully understood and require further study. The practical significance of this review is determined in the identification of potential therapeutic targets for the prevention of complications in COVID-19, as well as in expanding the possibilities of diagnosing SARS-CoV-2. Probably the crucial importance to reduce complications, as well as associated mortality, is the development of an effective method for modulating the immune response.

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The authors declare that there are no conflicts of interest present.