cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2022-86-138-148cfpd-1065Research ArticleОБЗОРЫREVIEWSАнализ медикаментозной терапии бронхиальной астмыAnalysis of drug therapy for bronchial asthmaЛиЕфэйLiYefei

Ли Ефэй, врач (магистр), отдел респираторной медицины

150001, г. Харбин, район Нэнган, ул. Южень, 23

Li Yefei, Physician (M.Sc.), Department of Respiratory Medicine

23 Youzheng Str., Nangang District, Harbin, 150001

ly13304560872@163.comЧжанВэйZhangWei

Чжан Вэй, профессор, заведующий отделением, отдел респиратор­ной медицины

150001, г. Харбин, район Нэнган, ул. Южень, 23

Zhang Wei, Professor, Head of Department, Department of Respiratory Medicine

23 Youzheng Str., Nangang District, Harbin, 150001

ЧенСюэChenXue

Чен Сюэ, врач (магистр), отдел респираторной медицины

150001, г. Харбин, район Нэнган, ул. Южень, 23

Chen Xue, Physician (M.Sc.), Department of Respiratory Medicine

23 Youzheng Str., Nangang District, Harbin, 150001

ПанЧэньюPangChenyou

Пан Чэнью, врач (магистр), отдел респираторной медицины

150001, г. Харбин, район Нэнган, ул. Южень, 23

Pang Chenyou, Medical Doctor (M.Sc.), Department of Respiratory Medicine

23 Youzheng Str., Nangang District, Harbin, 150001

Первая больница Харбинского медицинского университетаКитайHarbin Medical University First HospitalChinaПервая больница Харбинского медицинского университетаКитайHarbin Medical University First HospitalChina202223122022086138148Copyright © Ли Е., Чжан В., Чен С., Пан Ч., 20222022Ли Е., Чжан В., Чен С., Пан Ч.Li Y., Zhang W., Chen X., Pang C.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1065

В обзоре рассматриваются основные группы лекарственных препаратов, применяемых для лечения бронхиальной астмы (БА) в зависимости от степени тяжести заболевания. Подробно освещены механизмы дей­ствия и эффективность приема противоастматических препаратов, их комбинации и побочные эффекты. Особое внимание уделено таргетной терапии биологическими препаратами, действие которых направлено на снижение аллергического и воспалительного ответа у пациентов с тяжелой БА. Такой подход к терапии позволяет изменить естественный ход заболевания, уменьшить воспаление дыхательных путей без побочного повреждения, связанного с глюкокортикостероидами (ГКС). Изложенный обзор современных методов медикаментозной терапии, доступных в настоящее время, может быть полезен клиницистам для выбора подходящих стратегий лечения БА.

The review considers the main groups of drugs used to treat bronchial asthma depending on the severity of the disease. The mechanisms of action and effectiveness of taking anti-asthma drugs, their combinations and side effects are covered in detail. Particular attention is paid to targeted therapy with biological drugs, the action of which is aimed at reducing the allergic and inflammatory response in patients with severe asthma. This approach to therapy allows to change the natural course of the disease, reduce airway inflammation without side effects associated with glucocorticosteroids. The review of the current available drug therapies may be useful to clinicians in selecting appropriate strategies for the asthma treatment.

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The authors declare that there are no conflicts of interest present.