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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cfpd</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень физиологии и патологии дыхания</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin Physiology and Pathology of Respiration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5029</issn><publisher><publisher-name>Дальневосточный научный центр физиологии и патологии дыхания</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36604/1998-5029-2023-88-69-78</article-id><article-id custom-type="elpub" pub-id-type="custom">cfpd-1099</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Функциональное состояние щитовидной железы у детей, перенесших COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of the functional state of the thyroid gland in children who underwent COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Александровна Лазарева, канд. мед. наук, научный сотрудник группы клинической иммунологии и эндокринологии лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии, </p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1</p></bio><bio xml:lang="en"><p>Maria A. Lazareva, MD, PhD (Med.), Staff Scientist of the Group of Clinical Immunology and Endocrinology, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research, </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">m.lo85@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евсеева</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Evseeva</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галина Петровна Евсеева, д-р мед. наук, зам. директора по научной работе, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии,</p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1</p></bio><bio xml:lang="en"><p>Galina P. Evseeva, MD, PhD, DSc (Med.), Deputy Director on Scientific Work, Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research, </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">evceewa@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ракицкая</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakitskaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Викторовна Ракицкая, д-р мед. наук, профессор, зав. кафедрой госпитальной и факультетской педиатрии с курсом детских болезней; врач-эндокринолог </p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1; 680000, г. Хабаровск, ул. Муравьева-Амурского, 35</p></bio><bio xml:lang="en"><p>Elena V. Rakitskaya, MD, PhD, DSc (Med.), Professor, Head of Department of Hospital and Faculty Pediatrics, </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022; 35 Murav'eva-Amurskogo Str., Khabarovsk, 680000</p></bio><email xlink:type="simple">rakitskayaelena27@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Власова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vlasova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марина Александровна Власова, канд. мед. наук, старший научный сотрудник группы молекулярно-генетической диагностики лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии, </p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1</p></bio><bio xml:lang="en"><p>Marina A. Vlasova, MD, PhD (Med.), Senior Staff Scientist of Molecular Genetic Diagnostics Group, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research, </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пивкина</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pivkina</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Татьяна Владимировна Пивкина, врач-лаборант группы клинической иммунологии и эндокринологии лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии, </p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1</p></bio><bio xml:lang="en"><p>Tatiana V. Pivkina, MD, Laboratory Assistant of the Group of Clinical Immunology and Endocrinology, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research, </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супрун</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Suprun</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стефания Викторовна Супрун, д-р мед. наук, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии, </p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1</p></bio><bio xml:lang="en"><p>Stefania V. Suprun, MD, PhD, DSc (Med.), Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research, </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедько</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebed’ko</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Антоновна Лебедько, д-р мед. наук, директор</p><p>680022, г. Хабаровск, ул. Воронежская 49, корп. 1</p></bio><bio xml:lang="en"><p>Olga A. Lebed’ko, MD, PhD, DSc (Med.), Director </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Хабаровский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детства</institution></aff><aff xml:lang="en"><institution>Khabarovsk Branch of the Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Хабаровский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детства;&#13;
Федеральное государственное бюджетное образовательное учреждение высшего образования «Дальневосточный государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Khabarovsk Branch of the Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection;&#13;
Far Eastern State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>07</month><year>2023</year></pub-date><volume>0</volume><issue>88</issue><fpage>69</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазарева М.А., Евсеева Г.П., Ракицкая Е.В., Власова М.А., Пивкина Т.В., Супрун С.В., Лебедько О.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Лазарева М.А., Евсеева Г.П., Ракицкая Е.В., Власова М.А., Пивкина Т.В., Супрун С.В., Лебедько О.А.</copyright-holder><copyright-holder xml:lang="en">Lazareva M.A., Evseeva G.P., Rakitskaya E.V., Vlasova M.A., Pivkina T.V., Suprun S.V., Lebed’ko O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cfpd.elpub.ru/jour/article/view/1099">https://cfpd.elpub.ru/jour/article/view/1099</self-uri><abstract><p>Введение. Внелегочные проявления COVID-19 могут включать эндокринные формы, в том числе заболевания поджелудочной железы, гипофиза, гонад, щитовидной железы. Прямое цитопатическое действие вируса заключается в его способности проникать в клетки через рецептор ACE-2, расположенный на эпителиальных и эндотелиальных клетках эндокринных желез, последующей экспрессией, создающей возможность развития и прогрессирования заболеваний эндокринной системы, причем как воспалительного, так и аутоиммунного характера. До настоящего момента не до конца изучено функциональное coстояние щитовидной железы у детей и подростков в постковидном периоде, проживающих в регионе зобной эндемии (Дальневосточный федеральный округ). Цель. Оценить частоту встречаемости нарушений функции щитовидной железы у детей, перенесших COVID-19. Материалы и методы. В клинике проведено комплексное клинико-лабораторное обследование 41 ребенка в возрасте 5-17 лет, перенесших новую коронавирусную инфекцию. С помощью тест систем фирмы «Алкор-Био» (Санкт-Петербург) на микропланшетном ридере Stat-Fax 2100 (США) определены гормоны: тиреотропный гормон (ТТГ, мкЕд/мл), свободный тироксин (сТ4 , пмоль/л), антитела к тиреоидной пероксидазе. Результаты. Установлено, что у части детей встречались клинические симптомы, которые могут быть ассоциированы с возможной заинтересованностью тиреоидной системы: выраженная утомляемость (61,0%), сонливость (48,8%), снижение памяти (26,8%), подавленное настроение (14,6%), выпадение волос (14,6%), зябкость (4,9%), сухость кожных покровов (4,9%). УЗИ щитовидной железы выявило уменьшение объема железы у 46,3% и диффузное увеличение щитовидной железы у 9,8% пациентов. У 33,3% пациентов уровень ТТГ сыворотки крови превышал 3,4 мкЕд/мл, при нормальном уровне сТ4 , что соответствует субклиническому гипотиреозу. Заключение. Получены данные о возможности субклинического нарушения функции щитовидной железы у детей, перенесших коронавирусную инфекцию. Основываясь на патофизиологии инфекции SARS-CoV-2, при наличии клинических жалоб необходимо проводить рутинную оценку функции щитовидной железы у пациентов в восстановительной фазе и периоде реконвалесценции после COVID-19. Необходимы будущие проспективные исследования для повышения эпидемиологических и клинических знаний и оптимизации лечения заболеваний эндокринной системы у пациентов с COVID-19.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Extrapulmonary manifestations of COVID-19 may include endocrine forms, including diseases of the pancreas, pituitary gland, gonads, and thyroid gland. The direct cytopathic effect of the virus lies in its ability to enter cells through the ACE-2 receptor located on the epithelial and endothelial cells of the endocrine glands, followed by expression, which creates the possibility of the development and progression of damage to the endocrine system, both inflammatory and autoimmune. Until now, it has not been fully studied what changes in the state of health await children and teenagers in the post-COVID period, the dynamics of changes in the functional state of the thyroid gland in children and adolescents living in the region of endemic goiter (Far Eastern Federal District) has not been assessed. Aim. To assess of thyroid dysfunction in children who have had COVID-19. Materials and methods. The clinic performed a clinical and laboratory examination of 41 children aged 5-17 years who had a new coronavirus infection. Hormones were determined using the test systems of “AlkorBio” (St. Petersburg) on a microplate reader Stat-Fax 2100 (USA): thyroid stimulating hormone (µU/mL), free thyroxine (pmol/L), thyroid peroxidase antibodies. Results. It was determined that some children had clinical symptoms that may be associated with a possible involvement of the thyroid system: severe fatigue (61.0%), drowsiness (48.8%), memory loss (26.8%), depressed mood (14.6%), hair loss (14.6%), chilliness (4.9%), dry skin (4.9%). Ultrasound of the thyroid gland revealed a decrease in the volume of the gland in 46.3% and a diffuse enlargement of the thyroid gland in 9.8% of patients. In 33.3% of patients, the level of thyroid stimulating hormone in blood serum exceeded 3.4 mcU/mL, with a normal level of free thyroxine, which corresponds to subclinical hypothyroidism. Conclusion. The obtained data suggest the possibility of subclinical dysfunction of the thyroid gland in children who have had a coronavirus infection. Based on the pathophysiology of SARS-CoV-2 infection, with the presence of clinical complaints, it is necessary to conduct a routine assessment of thyroid function in patients in the recovery and convalescence phase after COVID-19. Future prospective studies are needed to improve epidemiological and clinical knowledge and optimize the management of endocrine diseases in patients with COVID-19. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция</kwd><kwd>дети</kwd><kwd>щитовидная железа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus infection</kwd><kwd>children</kwd><kwd>thyroid gland</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. (2021). COVID-19 disease in children and adolescents: scientific brief, 29 September 2021. World Health Organization. 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