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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cfpd</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень физиологии и патологии дыхания</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin Physiology and Pathology of Respiration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5029</issn><publisher><publisher-name>Дальневосточный научный центр физиологии и патологии дыхания</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36604/1998-5029-2024-92-117-133</article-id><article-id custom-type="elpub" pub-id-type="custom">cfpd-1177</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Анализ распространенности генов системы детоксикации (GSTM1, GSTT1) с учетом этнической принадлежности и экологических особенностей региона проживания</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of the prevalence of detoxification system genes (GSTM1, GSTT1) with regard to ethnicity and environmental characteristics of the region of residence</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супрун</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Suprun</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стефания Викторовна Супрун, д-р мед. наук, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии</p><p>680022, г. Хабаровск, ул. Воронежская, 49, корп. 1</p></bio><bio xml:lang="en"><p>Stefania V. Suprun, MD, PhD, DSc (Med.), Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research</p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудряшова</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryashova</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оксана Степановна Кудряшова, очный аспирант </p><p>680022, г. Хабаровск, ул. Воронежская, 49, корп. 1</p></bio><bio xml:lang="en"><p>Oksana S. Kudrayshova, Postgraduate student </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">kelemen_84@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супрун</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Suprun</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евгений Николаевич Супрун, канд. мед. наук, старший научный сотрудник группы медико-экологических проблем здоровья матери и ребенка лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии, Хабаровский филиал Федерального   государственного   бюджетного   научного   учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детства; доцент кафедры госпитальной и факультетской терапии с курсом пропедевтики детских болезней, Федеральное государственное бюджетное образовательное учреждение высшего образования «Дальневосточный государственный медицинский университет»; </p><p>680022, г. Хабаровск, ул. Воронежская, 49, корп. 1,</p><p>680000, г. Хабаровск, ул. Муравьева-Амурского, 35</p></bio><bio xml:lang="en"><p>Evgeniy N. Suprun, MD, PhD (Med.), Senior Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research, Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection; Associate Professor of Department of Hospital and Faculty Pediatrics with a Course of Propaedeutic of Children’s Diseases, Far Eastern State Medical University</p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наговицына</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Nagovitsina</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Борисовна Наговицына, канд. мед. наук, ведущий научный сотрудник группы молекулярно-генетических методов исследования лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии</p><p>680022, г. Хабаровск, ул. Воронежская, 49, корп. 1</p></bio><bio xml:lang="en"><p>Elena B. Nagovitsina, MD, PhD (Med.), Main Staff Scientist of Molecular Genetic Diagnostics Group, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research</p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евсеева</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Evseeva</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галина Петровна Евсеева, д-р мед. наук, зам. директора по научной работе, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии</p><p>680022, г. Хабаровск, ул. Воронежская, 49, корп. 1</p></bio><bio xml:lang="en"><p>Galina P. Evseeva, MD, PhD, DSc (Med.), Deputy Director on Scientific Work, Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research</p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">evceewa@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедько</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebed'ko</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Антоновна Лебедько, д-р мед. наук, директор</p><p>680022, г. Хабаровск, ул. Воронежская, 49, корп. 1</p></bio><bio xml:lang="en"><p>Olga A. Lebed’ko, MD, PhD, DSc (Med.), Director </p><p>49/1 Voronezhskaya Str., Khabarovsk, 680022</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Хабаровский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детства</institution></aff><aff xml:lang="en"><institution>Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Хабаровский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детства;&#13;
Федеральное государственное бюджетное образовательное учреждение высшего образования «Дальневосточный государственный медицинский университет»</institution></aff><aff xml:lang="en"><institution>Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection;&#13;
Far Eastern State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>19</day><month>06</month><year>2024</year></pub-date><volume>0</volume><issue>92</issue><fpage>117</fpage><lpage>133</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Супрун С.В., Кудряшова О.С., Супрун Е.Н., Наговицына Е.Б., Евсеева Г.П., Лебедько О.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Супрун С.В., Кудряшова О.С., Супрун Е.Н., Наговицына Е.Б., Евсеева Г.П., Лебедько О.А.</copyright-holder><copyright-holder xml:lang="en">Suprun S.V., Kudryashova O.S., Suprun E.N., Nagovitsina E.B., Evseeva G.P., Lebed'ko O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cfpd.elpub.ru/jour/article/view/1177">https://cfpd.elpub.ru/jour/article/view/1177</self-uri><abstract><p>Гены суперсемейства глутатион-S-трансфераз (GSTT1, GSTM1) кодируют ферменты системы 2 фазы детоксикации, их мутации повышают чувствительность организма к воздействию повреждающих факторов и развитию различных заболеваний. Цель работы: представить эколого-этнические особенности распределения полиморфных вариантов данных генов на основе анализа отечественной и зарубежной литературы. В статье описаны функциональные эффекты генетических полиморфизмов, показана различная частота встречаемости полиморфных вариантов генов GSTM1 и GSTT1 в зависимости от расовой принадлежности в России и мире. Особое внимание уделено особенностям распространенности полиморфизмов генов детоксикации у коренного и пришлого населения Приамурья. На основании проведенного анализа данных литературы сделан вывод о важности учета этнической принадлежности, условий проживания и состояния генов «предрасположенности» для разработки персонифицированного подхода к прогнозированию, профилактике и лечению.</p></abstract><trans-abstract xml:lang="en"><p>Glutathione S-transferase superfamily genes (GSTT1, GSTM1) encode phase II detoxification system enzymes; their mutations increase the sensitivity of the organism to the impact of damaging factors and the development of various diseases. Objective: to present the ecological and ethnic features of the distribution of polymorphic variants of these genes based on the analysis of domestic and foreign literature. The article describes the functional effects of genetic polymorphisms and shows the different frequency of polymorphic variants of GSTM1 and GSTT1 genes depending on race in Russia and the world. Special attention is given to the prevalence features of detoxification gene polymorphisms among the indigenous and migrant populations of the Amur region. Based on the literature data analysis, the conclusion is made about the importance of considering ethnic background, living conditions, and the state of "predisposition" genes for developing a personalized approach to prediction, prevention, and treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гены системы детоксикации</kwd><kwd>GSTT1</kwd><kwd>GSTM1</kwd><kwd>коренное</kwd><kwd>пришлое население</kwd><kwd>расы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>detoxification system genes</kwd><kwd>GSTT1</kwd><kwd>GSTM1</kwd><kwd>indigenous population</kwd><kwd>migrant population</kwd><kwd>races</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов В.С. 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