cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2024-92-134-142cfpd-1178Research ArticleОБЗОРЫREVIEWSРоль Толл-подобных рецепторов и их мутаций в патогенезе цитомегаловирусной инфекцииThe role of Toll-like receptor polymorphism in pathogenesis of cytomegalovirus infectionhttps://orcid.org/0000-0003-0212-0201АндриевскаяИ. А.AndrievskayaI. A.

Ирина Анатольевна Андриевская, д-р биол. наук, профессор РАН, зав. лабораторией механизмов этиопатогенеза и восстановительных процессов дыхательной системы при неспецифических заболеваниях легких

675000, г. Благовещенск, ул. Калинина, 22

Irina A. Andrievskaya, PhD, D.Sc. (Biol.), Professor RAS, Head of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases

22 Kalinina Str., Blagoveshchensk, 675000

irinaandrievskaja@rambler.ruhttps://orcid.org/0000-0002-6235-8732УстиновЕ. М.UstinovE. M.

Егор Михайлович Устинов, лаборант-исследователь, лаборатория механизмов этиопатогенеза и восстановительных процессов дыхательной системы при неспецифических заболеваниях легких

675000, г. Благовещенск, ул. Калинина, 22

Egor M. Ustinov, Research Laboratory Assistant, Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases

22 Kalinina Str., Blagoveshchensk, 675000

eustinov.asma@gmail.comhttps://orcid.org/0000-0003-3718-9962ГассанД. А.GassanD. A.

Дина Анатольевна Гассан, канд. мед. наук, научный сотрудник, лаборатория молекулярных и трансляционных исследований

675000, г. Благовещенск, ул. Калинина, 22

Dina A. Gassan, PhD (Med.), Staff Scientist, Laboratory of Molecular and Translational Research

22 Kalinina Str., Blagoveshchensk, 675000

dani-shi@mail.ruФедеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания»Far Eastern Scientific Center for Physiology and Pathology of Respiration202419062024092134142Copyright © Андриевская И.А., Устинов Е.М., Гассан Д.А., 20242024Андриевская И.А., Устинов Е.М., Гассан Д.А.Andrievskaya I.A., Ustinov E.M., Gassan D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1178

Толл-подобные рецепторы (TLR) представляют собой образ-распознающие рецепторы, которые экспрессируются во многих иммунных и неимунных клетках, и выполняют решающую роль в развитии воспаления и связанных с ним инфекционных заболеваний.

Цель

Цель. Обобщить знания о роли TLR и их генетических изменений в развитии цитомегаловирусной (ЦМВ) инфекции во время беременности и врожденной инфекции у новорожденных.

Материал и методы

Материал и методы. Систематический поиск литературы, содержащей информацию о соответствующих исследованиях, проводился в системах PubMed и Google Scholar. В обзор вошел анализ 42 англоязычных и русскоязычных статей. Глубина поиска составила 19 лет за период с 2004 по 2023 годы. Поиск проводился по ключевым словам: Толл-подобные рецепторы, цитомегаловирус, полиморфизмы, внутриутробная инфекция.

Результаты

Результаты. В работе представлены сведения о структуре и типах TLR, раскрыты основные молекулярные механизмы, с помощью которых рецепторы участвуют в регуляции иммунной системы и развитии воспаления при инфицировании. Продемонстрирована потенциальная роль TLR и их генетической изменчивости в патогенезе ЦМВ инфекции, как в общей популяции людей, так и у беременных. Также определено их возможное участие в развитии врожденной ЦМВ инфекции у новорожденных.

Заключение

Заключение. Результаты могут быть использованы для разработки терапевтических мишеней с целью их возможного применения для иммунокоррекции воспаления, вызванного ЦМВ инфицированием.

Introduction

Introduction. Toll-like receptors (TLRs) are pattern-recognition receptors that are expressed in many immune and non-immune cells, playing a crucial role in the development of inflammation and associated infectious diseases.

Aim

Aim. To summarize the knowledge about the role of TLRs and their genetic variations in the development of cytomegalovirus (CMV) infection during pregnancy and congenital infection in newborns.

Materials and methods

Materials and methods. A systematic literature search was conducted in PubMed and Google Scholar for relevant studies. A total of 42 English-language articles and a Russian-language article were reviewed, covering a period of 19 years from 2004 to 2023. The search was conducted using the keywords: Toll-like receptors, cytomegalovirus, polymorphisms, intrauterine infection. The potential role of TLRs and their genetic variability in the pathogenesis of CMV infection both in the general population and in pregnant women is demonstrated. Their possible involvement in the development of congenital CMV infection in newborns is also identified.

Conclusion

Conclusion. The results could be used to develop therapeutic targets aimed at potential application for immune correction of inflammation caused by CMV infection.

Results

Results. The paper shows the knowledge on the structure and types of TLRs, revealing the main molecular mechanisms by which the receptors participate in the regulation of the immune system and the development of inflammation during infection.

 

 

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The authors declare that there are no conflicts of interest present.