cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2024-93-141-155cfpd-1196Research ArticleОБЗОРЫREVIEWSРоль неферментирующих грамотрицательных бактерий Stenotrophomonas maltophilia в этиологии инфекционных заболеваний (обзор литературы)The role of non-fermenting gram-negative bacteria Stenotrophomonas maltophilia in the etiology of infectious diseases (review)https://orcid.org/0000-0002-7598-7343ГолубеваА. О.GolubevaA. O.

Александра Олеговна Голубева, младший научный сотрудник, лаборатория бактериальных инфекций

680000, г. Хабаровск, ул. Шевченко, д.2

Aleksandra O. Golubeva, Junior Staff Scientist, Laboratory of Bacterial Infections

2 Shevchenko Str., Khabarovsk, 680000

baclab_hniiem@bk.ruhttps://orcid.org/0000-0002-9197-8519БондаренкоА. П.BondarenkoA. P.

Альбина Павловна Бондаренко, канд. мед. наук, ведущий научный сотрудник, зав. лабораторией бактериальных инфекций

680000, г. Хабаровск, ул. Шевченко, д.2

Albina P. Bondarenko, MD, PhD (Med.), Leading Staff Scientist, Head of Laboratory of Bacterial Infections

2 Shevchenko Str., Khabarovsk, 680000

allalab2203@gmail.comhttps://orcid.org/0000-0003-3050-4472ТроценкоO. E.TrotsenkoO. E.

Ольга Евгеньевна Троценко, д-р мед. наук, директор

680000, г. Хабаровск, ул. Шевченко, д.2

Olga E. Trotsenko, MD, PhD, DSc (Med.), Director

2 Shevchenko Str., Khabarovsk, 680000

adm@hniiem.ruhttps://orcid.org/0000-0003-3872-0006ОгиенкоО. Н.OgienkoO. N.

Ольга Николаевна Огиенко, младший научный сотрудник, лаборатория бактериальных инфекций

680000, г. Хабаровск, ул. Шевченко, д.2

Ogienko Olga Nikolaevna, Junior Staff Scientist, Laboratory of Bacterial Infections

2 Shevchenko Str., Khabarovsk, 680000

baclab_hniiem@bk.ruФедеральное бюджетное учреждение науки «Хабаровский научно-исследовательский институт эпидемиологии и микробиологии» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаFederal Budgetary Institution of Science "Khabarovsk Scientific Research Institute of Epidemiology and Microbiology" of the Federal Service for Supervision of Consumer Rights Protection and Human Well-being202413092024093141155Copyright © Голубева А.О., Бондаренко А.П., Троценко O.E., Огиенко О.Н., 20242024Голубева А.О., Бондаренко А.П., Троценко O.E., Огиенко О.Н.Golubeva A.O., Bondarenko A.P., Trotsenko O.E., Ogienko O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1196

Грамотрицательные бактерии Stenotrophomonas maltophilia занимают третье место среди неферментирующих грамотрицательных бактерий по частоте выявления при инфекционной патологии различной локализации. В данном обзоре представлены сведения о различных факторах вирулентности, механизмах, используемых S. maltophilia для колонизации и заражения организма человека, множественной лекарственной устойчивости, клинических проявлениях вызываемых заболеваний и методах бактериологической диагностики. Подчеркнута важность ранней идентификации данного патогена для практикующих врачей. Обсужден выбор препарата для терапии инфекций, обусловленных S. maltophilia, являющийся сложной задачей как для клиницистов, так и для микробиологов. С этой целью изучены современные отечественные и зарубежные научные публикации с использованием поисковых систем научных электронных библиотек – PubMed, Google Scholar, eLIBRARY.ru, КиберЛенинка.

Gram-negative bacteria Stenotrophomonas maltophilia rank third among non-fermenting gram-negative bacteria in terms of detection frequency in various infectious pathologies. This review presents information on the various virulence factors, mechanisms used by S. maltophilia for colonization and infection of the human body, multiple drug resistance, clinical manifestations of the diseases caused, and methods of bacteriological diagnosis. The importance of early identification of this pathogen for practicing physicians is emphasized. The selection of treatment for infections caused by S. maltophilia is discussed, highlighting the challenges faced by both clinicians and microbiologists. To this end, current domestic and international scientific publications were reviewed using scientific electronic library search engines such as PubMed, Google Scholar, eLIBRARY.ru, and CyberLeninka.

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The authors declare that there are no conflicts of interest present.