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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cfpd</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень физиологии и патологии дыхания</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin Physiology and Pathology of Respiration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5029</issn><publisher><publisher-name>Дальневосточный научный центр физиологии и патологии дыхания</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36604/1998-5029-2024-94-141-157</article-id><article-id custom-type="elpub" pub-id-type="custom">cfpd-1216</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Долгосрочные проблемы связанного со здоровьем  качества жизни, обусловленные пандемией COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Long-term health-related quality of life issues associated  with the COVID-19 pandemic</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перельман</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Perelman</surname><given-names>N. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Львовна Перельман, д-р мед. наук, ведущий научный сотрудник, лаборатория молекулярных и трансляционных исследований</p><p>675000, г. Благовещенск, ул. Калинина, 22</p></bio><bio xml:lang="en"><p>Natalia L. Perelman, MD, PhD, DSc (Med.), Leading Staff Scientist, Laboratory of Molecular and Translational Research</p><p>22 Kalinina Str., Blagoveshchensk, 675000</p></bio><email xlink:type="simple">lvovna63@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания»</institution></aff><aff xml:lang="en"><institution>Far Eastern Scientific Center of Physiology and Pathology of Respiration</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>12</month><year>2024</year></pub-date><volume>0</volume><issue>94</issue><fpage>141</fpage><lpage>157</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Перельман Н.Л., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Перельман Н.Л.</copyright-holder><copyright-holder xml:lang="en">Perelman N.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cfpd.elpub.ru/jour/article/view/1216">https://cfpd.elpub.ru/jour/article/view/1216</self-uri><abstract><p>Пандемия COVID-19 проявила огромный потенциал негативного воздействия на качество жизни (КЖ) населения в целом, вызвав психологический стресс, нарушив полноценное участие в повседневной жизни и уменьшив ощущение связи с социумом. Цель настоящего обзора литературы состояла в оценке влияния длительного COVID-19 и связанных с ним факторов на КЖ населения, его физические, эмоциональные и социальные аспекты. Высокий уровень утомляемости после COVID-19 снижает трудоспособность, обусловливает потерю социальных связей, усиливает депрессивную симптоматику и приводит к снижению КЖ в долгосрочной перспективе. Показано, что КЖ значительно ниже у женщин, чем у мужчин, а мужской пол является одним из факторов риска тяжелого течения COVID-19. Ухудшение связанного со здоровьем КЖ на протяжении всей пандемии отмечено у детей и подростков, оказавшихся особенно уязвимыми к социальному дистанцированию. Вакцинация против COVID-19 явилась значимым предиктором более высокого физического КЖ. Большинство прошедших медицинскую реабилитацию в целом также имеют высокий уровень КЖ, хотя некоторые пациенты продолжают отмечать определенные проблемы функционального характера. Опубликованные научные работы демонстрируют ряд нерешенных методологических и методических вопросов оценки изменений связанного со здоровьем КЖ в результате пандемии COVID-19. В связи с высокой гетерогенностью исследований существует необходимость в разработке подходов к уменьшению их неоднородности, использовании проверенных инструментов оценки, широко признанных вопросников и конкретных сроках последующего наблюдения. Стандартизированные и долговременные исследования COVID-19, несомненно, будут иметь неоценимое значение для понимания эпидемиологии и влиянии бремени длительного COVID на связанное со здоровьем КЖ.</p></abstract><trans-abstract xml:lang="en"><p>The factors shaping the effects of the COVID-19 pandemic are more pronounced, more widespread, and longer lasting than just the somatic effects of infection, with serious deterioration in people's actual and perceived quality of life (QoL). The COVID-19 pandemic has shown great potential to directly impact on the QoL of the general population, causing psychological distress, disrupting full participation in daily life and reducing the sense of connection to society. The aim of this review was to assess the impact of Long-COVID and related factors on the population's QoL, its physical, emotional and social aspects. High levels of fatigue after COVID-19 reduce work capacity, account for the loss of social ties, and increase depressive symptoms and lead to lower long-term QoL. Studies have shown that QoL is significantly lower in women than in men, and male gender is one of the risk factors for a severe course of COVID-19. Deterioration in health-related CV throughout the pandemic was noted in children and adolescents, who were particularly vulnerable to social distancing. Vaccination against COVID-19 was a significant predictor of higher physical QoL. The majority of those who underwent medical rehabilitation also have a high level of physical functioning, although some patients continue to report some functional problems. Published scientific papers demonstrate a number of unresolved methodological and methodological issues in assessing changes in health-related QoL as a result of the COVID-19 pandemic. Due to the high heterogeneity of studies, there is a need to develop approaches to reduce heterogeneity, use validated assessment tools, widely accepted questionnaires and specific follow-up timeframes. Standardized and long-term COVID-19 studies will undoubtedly be invaluable in understanding the epidemiology and impact of the burden of Long-COVID on health-related QoL.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>качество жизни</kwd><kwd>длительный COVID-19</kwd><kwd>тревога и депрессия</kwd><kwd>социальные проблемы</kwd><kwd>гендер</kwd><kwd>психоэмоциональный статус</kwd><kwd>вакцинация</kwd><kwd>реабилитация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>quality of life</kwd><kwd>long-term COVID-19</kwd><kwd>anxiety and depression</kwd><kwd>social problems</kwd><kwd>gender</kwd><kwd>psycho-emotional  status</kwd><kwd>vaccination</kwd><kwd>rehabilitation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO COVID-19 dashboard. Available at URL: https://covid19.who.int/ (03.10.2024).</mixed-citation><mixed-citation xml:lang="en">WHO COVID-19 dashboard. 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