cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2025-95-135-148cfpd-1241Research ArticleОБЗОРЫREVIEWSБронхиальная астма и COVID-19 (обзор литературы)Asthma and COVID-19 (review)https://orcid.org/0000-0003-1041-6088КругловаО. С.KruglovaO. S.

Ольга Сергеевна Круглова, ассистент кафедры госпитальной терапии и иммунологии с курсом постдипломного образования

660022, г. Красноярск, ул. Партизана Железняка, 1

Olga S. Kruglova, MD, Assistant of the Department of Hospital Therapy and Immunology with a Postgraduate Course

1 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

kruglovaos95@gmail.comhttps://orcid.org/0000-0002-9377-5213СобкоЕ. А.SobkoE. A.

Елена Альбертовна Собко, д-р мед. наук, профессор кафедры госпитальной терапии и иммунологии с курсом последипломного образования; зав. отделением аллергологии 

660022, г. Красноярск, ул. Партизана Железняка, 1 

660022, г. Красноярск, ул. Партизана Железняка, 3

Elena A. Sobko, MD, PhD, DSc (Med.), Professor of the Department of Hospital Therapy and Immunology with a Postgraduate Course; Head of the Allergology Department

1 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

3 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

sobko29@mail.ruhttps://orcid.org/0000-0001-8982-5292ДемкоИ. В.DemkoI. V.

Ирина Владимировна Демко, д-р мед. наук, профессор, зав. кафедрой госпитальной терапии и иммунологии с курсом последипломного образования; зав. легочно-аллергологическим центром

660022, г. Красноярск, ул. Партизана Железняка, 1 

660022, г. Красноярск, ул. Партизана Железняка, 3

Irina V. Demko, MD, PhD, DSc (Med.), Professor, Head of Department of Hospital Therapy and Immunology with Postgraduate Education Course; Head of Pulmonary Allergology Сenter

1 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

3 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

demko64@mail.ruhttps://orcid.org/0000-0001-6896-877XКрапошинаА. Ю.KraposhinaA. Yu.

Ангелина Юрьевна Крапошина, канд. мед. наук, доцент, доцент кафедры госпитальной терапии и иммунологии с курсом последипломного образования; врач-пульмонолог отделения пульмонологии 

660022, г. Красноярск, ул. Партизана Железняка, 1 

660022, г. Красноярск, ул. Партизана Железняка, 3

Angelina Yu. Kraposhina, MD, PhD (Med.), Associate Professor, Associate Professor of Department of Hospital Therapy and Immunology with a Postgraduate Education Course; Pulmonologist of Department of Pulmonology

1 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

3 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

angelinamaria@inbox.ruhttps://orcid.org/0000-0002-6595-3000ХрамоваЮ. А.KhramovaU. A.

Юлия Александровна Храмова, студент

660022, г. Красноярск, ул. Партизана Железняка, 1 

Uliya A. Khramova, student

1 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

khramova.iu@yandex.ruhttps://orcid.org/0000-0002-9492-2668ГейльС. А.Geyl'S. A.

София Андреевна Гейль, студент

660022, г. Красноярск, ул. Партизана Железняка, 1 

Sophiya A. Geyl', student

1 Partizana Zheleznyaka Str., Krasnoyarsk, 660022

sofi20939@yandex.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф.Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииFederal State Budgetary Educational Institution of Higher Education «Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of the Ministry of Healthcare of the Russian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф.Войно-Ясенецкого» Министерства здравоохранения Российской Федерации; Краевое государственное бюджетное учреждение здравоохранения «Краевая клиническая больница»Federal State Budgetary Educational Institution of Higher Education «Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of the Ministry of Healthcare of the Russian Federation; Regional State Budgetary Healthcare Institution «Regional Clinical Hospital»202520032025095135148Copyright © Круглова О.С., Собко Е.А., Демко И.В., Крапошина А.Ю., Храмова Ю.А., Гейль С.А., 20252025Круглова О.С., Собко Е.А., Демко И.В., Крапошина А.Ю., Храмова Ю.А., Гейль С.А.Kruglova O.S., Sobko E.A., Demko I.V., Kraposhina A.Y., Khramova U.A., Geyl' S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1241

Проведен анализ и систематизация научной литературы, посвященной проблеме сочетания бронхиальной астмы (БА) и COVID-19 с использованием электронных баз данных PubMed/MEDLINE и eLIBRARY.RU. Показана противоречивость данных о связи между БА и COVID-19. Обсужден механизм развития воспаления и его особенности при новой коронавирусной инфекции. Подчеркнута важная роль натуральных и Т-натуральных киллеров в патогенезе заболевания. Сделан вывод о значимости типа воспаления при БА для риска заражения SARS-CoV-2. Представлена информация о двойственности сведений относительно применения ингаляционных глюкокортикостероидов при лечении БА у пациентов, болеющих COVID-19. В статье авторы приходят к заключению о том, что результаты имеющихся на сегодняшний день исследований не позволяют сделать однозначного вывода о большей предрасположенности к инфекции SARS-CoV-2 и о более тяжелом течении COVID-19 у больных бронхиальной астмой и, наоборот, о негативном влиянии COVID-19 на течение и контроль бронхиальной астмы. 

An analysis and systematization of scientific literature on the combination of asthma and COVID-19 was conducted using the scientific databases PubMed/MEDLINE and eLIBRARY.RU. The data on the relationship between asthma and COVID-19 are shown to be contradictory. The mechanism of inflammation development and its characteristics in the new coronavirus infection are discussed. The significant role of natural killer (NK) cells and T-natural killer (T-NK) cells in the pathogenesis of the disease is emphasized. The importance of the type of inflammation in asthma in the risk of SARS-CoV-2 infection is concluded. Information on the dual nature of the data regarding the use of inhaled corticosteroids in the treatment of asthma in patients with COVID-19 is presented. The authors conclude that the results of current research do not allow a definitive conclusion to be drawn about a higher predisposition to SARS-CoV-2 infection or more severe COVID-19 in asthma patients, nor about the negative impact of COVID-19 on the course and control of asthma.  

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The authors declare that there are no conflicts of interest present.