References

cfpd

Бюллетень физиологии и патологии дыхания

Bulletin Physiology and Pathology of Respiration

1998-5029

Дальневосточный научный центр физиологии и патологии дыхания

10.12737/article_5b985a4bcfb950.60653849

cfpd-128

Research Article

Статьи

РОЛЬ ЖИРНЫХ КИСЛОТ В ЭМБРИОНАЛЬНОМ РАЗВИТИИ (ОБЗОР ЛИТЕРАТУРЫ)

THE ROLE OF FATTY ACIDS IN EMBRYONIC DEVELOPMENT (REVIEW)

Ишутина

Н. А.

Ishutina

N. A.

ishutina-na@mail.ru

Дальневосточный научный центр физиологии и патологии дыханияFar Eastern Scientific Center of Physiology and Pathology of Respiration

2018

18112019

069107114

2019

Ишутина Н.А.

Ishutina N.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://cfpd.elpub.ru/jour/article/view/128

В обзоре приведены сведения о физиологической роли среднецепочечных насыщенных и ненасыщенных (миристиновая, пентадекановая) и длинноцепочечных (пальмитиновая, стеариновая, олеиновая) жирных кислот в эмбриональном развитии. Показано значение жирных кислот в образовании сурфактанта легких развивающегося плода. Приведены сведения о роли полиненасыщенных кислот ω-6 семейства арахидоновой и докозагексаеновой в структурном и функциональном развитии нервной системы, зрительного анализатора плода и новорожденного. Показано взаимообусловленное стимулирующее действие ненасыщенных олеиновой и линолевой жирных кислот на дифференцировку мышечных клеток, продемонстрирована роль олеиновой и кислот с 20 углеродными атомами в минерализации костной ткани, представлено значение олеиновой кислоты в регуляции плацентарного транспорта аминокислот через толл-подобные рецепторы 4 и клеточную сигнализацию. Вышеизложенное позволяет сделать заключение о необходимости дальнейшего изучения липидов как основных энергетических субстратов; источников пластического материала; структурных компонентов мембран эритроцитов, нервной ткани, зрительного анализатора, легочного сурфактанта, скелетной мускулатуры. Накопленные данные расширяют представления о роли липидов в метаболических процессах, что позволит перейти от фундаментально-поисковых работ к практическим аспектам применения данных веществ в акушерстве и перинатологии. В перспективе эти результаты могут быть использованы при интерпретации и прогнозировании изменений метаболических нарушений липидов при различных патологических состояния во время беременности.

The review provides information on the physiological role of medium-chain saturated and unsaturated (myristic, pentadecanoic) and long-chain (palmitic, stearic, oleic) fatty acids in embryonic development. The value of fatty acids in the formation of the lung surfactant of the developing fetus is shown. There is presented the information about the role of polyunsaturated acids of arachidonic and docosahexaenoic ω-6 family in the structural and functional development of the nervous system and the visual analyzer of the fetus and the newborn. The interdependent stimulating effect of unsaturated oleic and linoleic fatty acids on the differentiation of muscle cells is shown; the role of oleic and acids with 20 carbohydrate atoms in the mineralization of bone tissue is demonstrated; the value of oleic acid in the regulation of placental transport of amino acids through tol-like receptors 4 and cellular signaling is presented. The above mentioned factors allow drawing the conclusion about the need for further study of lipids as the main energy substrates, sources of plastic material, structural components of erythrocyte membranes, nerve tissue, visual analyzer, pulmonary surfactant and skeletal muscles. The accumulated data broadens the understanding of the role of lipids in metabolic processes, which will allow us to move from a fundamental research to practical aspects of the use of these substances in obstetrics and perinatology. In the long term, these results can be used to interpret and predict changes in metabolic disorders of lipids in various pathological conditions during pregnancy.

жирные кислотыэмбриональное развитие

fatty acidsembryonic development

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The authors declare that there are no conflicts of interest present.