cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2025-98-163-174cfpd-1306Research ArticleОБЗОРЫREVIEWSНекоторые аспекты коморбидности псориаза и бронхолегочной патологии (обзор литературы)Some aspects of comorbidity between psoriasis and bronchopulmonary pathology (literature review)СупрунС. В.SuprunS. V.

Стефания Викторовна Супрун, д-р мед. наук, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка лаборатории комплексных методов исследования бронхолегочной и перинатальной патологии

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

Stefania V. Suprun, MD, PhD, DSc (Med.), Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research

49/1 Voronezhskaya Str., Khabarovsk, 680022

evg-suprun@yandex.ruМакееваМ. И.MakeevaM. I.

Мария Игоревна Макеева, зав. дерматовенерологическим отделением, врач дерматовенеролог

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

680003, г. Хабаровск, ул. Ангарская, 5

Mariya I. Makeeva, Head of the Dermatovenereology Department, Dermatovenereologist

49/1 Voronezhskaya Str., Khabarovsk, 680022

5 Angarskaya Str., Khabarovsk, 680003

mariababkova@gmail.comХабаровский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детстваKhabarovsk Branch of the Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood ProtectionХабаровский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детства; Краевое государственное бюджетное учреждение здравоохранения «Краевой кожно-венерологический диспансер» министерства здравоохранения Хабаровского краяKhabarovsk Branch of the Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection; Regional State Budgetary Healthcare Institution "Regional Dermatovenerologic Dispensary" of the Ministry of Healthcare of the Khabarovsk Krai202523122025098163174Copyright © Супрун С.В., Макеева М.И., 20252025Супрун С.В., Макеева М.И.Suprun S.V., Makeeva M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1306

Введение. Псориаз является одним из самых распространенных дерматозов среди взрослых и детей. Описывается его течение, ассоциированное с заболеваниями легких у взрослых пациентов.Цель. Проанализировать накопленную информацию о распространённости, возможных патофизиологических механизмах воспаления при псориазе и хронических бронхолегочных заболеваниях, обусловленных взаимными процессами, генетической предрасположенностью для оценки последующих прогностических вариантов ранней профилактики.Материалы и методы. Проведен поиск литературных источников глубиной более 50 лет в базах данных PubMed, PlamX, Researh Gate, the BMJ, Elsevier с выбором типов статей «Clinical Trial», «Meta-Analysis», «Review», «Systematic Review».Результаты. Анализ опубликованных работ показал не высокий процент коморбидности между псориазом и патологией бронхолегочной системы. Представлены некоторые общие патогенетические механизмы воспаления, действие специализированной терапии. Определены общие факторы риска, приводящие к развитию псориаза и других заболеваний, прежде всего бронхолегочной системы. Сходства включают иммунные процессы, профили цитокинов и типы иммунных клеток. Проанализированы несколько генетических вариантов, связывающих псориаз и нарушение функции легких, закладывая основу для будущих исследований.Заключение. Недостаточное количество исследований сочетания двух нозологий, особенно в детском возрасте, предрасполагает к дальнейшему изучению проблемы и выявлению общих биомаркеров на более ранних этапах онтогенеза для диагностики, прогноза и обоснования современной коррекции.

Introduction. Psoriasis is one of the most common dermatoses among both adults and children. Its course associated with pulmonary diseases in adult patients has been described.Aim. To analyze the accumulated data on the prevalence and possible pathophysiological mechanisms of inflammation in psoriasis and chronic bronchopulmonary diseases driven by shared processes and genetic predisposition, in order to assess the potential for future prognostic approaches and early prevention strategies.Materials and methods. A literature search spanning more than 50 years was conducted in the PubMed, PlamX, ResearchGate, The BMJ, and Elsevier databases, selecting articles categorized as "Clinical Trial", "Meta-Analysis", "Review", and "Systematic Review".Results. Analysis of published studies revealed a relatively low percentage of comorbidity between psoriasis and bronchopulmonary pathology. Several common pathogenetic mechanisms of inflammation and the effects of specialized therapies are presented. Shared risk factors contributing to the development of psoriasis and other diseases—particularly those affecting the bronchopulmonary system—have been identified. These similarities include immune processes, cytokine profiles, and types of immune cells involved. Several genetic variants linking psoriasis with impaired lung function have been analyzed, laying the groundwork for future research.Conclusion. The insufficient study of the co-occurrence of these two nosological entities – especially in childhood necessitates further investigation and identification of – biomarkers at earlier stages of ontogenesis to enable timely diagnosis, prognosis, and evidence-based therapeutic interventions.

псориазхронические дерматозыхронические заболевания бронхолегочной системыбронхиальная астмахронический обструктивный бронхиткоморбидные состоянияpsoriasischronic dermatoseschronic diseases of the bronchopulmonary systemasthmachronic obstructive bronchitiscomorbid conditionsReferencesКлинические рекомендации. Псориаз. М.: Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов», 2023. URL: https://cr.minzdrav.gov.ru/preview-cr/234_2[Clinical recommendations. Psoriasis]. Moscow: Obshcherossiyskaya obshchestvennaya organizatsiya "Rossiyskoye obshchestvo dermatovenerologov i kosmetologov"; 2023 (in Russian). Available at: https://cr.minzdrav.gov.ru/previewcr/234_2Skayem C., Taieb C., Halioua B., Baissac C., Saint Aroman M. Epidemiology of psoriasis: a worldwide global study // Acta Derm. Venereol. 2025. Vol.105. Article number:adv42945. https://doi.org/10.2340/actadv.v105.42945Skayem C., Taieb C., Halioua B., Baissac C., Saint Aroman M. Epidemiology of psoriasis: a worldwide global study. Acta Derm. Venereol. 2025; 105:adv42945. https://doi.org/10.2340/actadv.v105.42945Гришко Т.Н., Опарин Р.Б., Бассе Ф.Б., Труфанова Е.Ю., Мордовцев В.Н. Псориаз у детей // Вестник дерматологии и венерологии. 2005. №1. С.59. EDN: ILFWFX.Grishko T.N., Oparin R.B., Basse F.B., Trufanova E.Yu., Mordovtsev V.N. [Psoriasis in children]. Vestnik Dermatologii i Venerologii 2005; 1:59 (in Russian).Murzina E. Pediatric psoriasis: clinical features and course // OAJBS. 2020. Vol.1, №5. P.207–209. https://doi.org/10.38125/OAJBS.000147Murzina E. Pediatric psoriasis: clinical features and course. OAJBS 2020; 1(5):207–209. https://doi.org/10.38125/OAJBS.000147Агафонова Ю.В., Симонова Д.Л., Симонов С.Н. Оценка качества жизни детей, страдающих псориазом // Медицина и физическая культура: наука и практика. 2021. Т.3, №4. С.41–48. https://doi.org/10.20310/2658-7688-2021-3-4(12)-41-48Agafonova Yu.V., Simonova D.L., Simonov S.N. [Quality of life assessment among children with psoriasis]. Meditsina i fizicheskaya kul'tura: nauka i praktika = Medicine and physical education: science and practice 2021; 3(4):41– 48 (in Russian). https://doi.org/10.20310/2658-7688-2021-3-4(12)-41-48Augustin M., Glaeske G., Radtke M.A., Christophers E., Reich K., Schäfer I. Epidemiology and comorbidity of psoriasis in children // Br. J. Dermatol. 2010. Vol.162, №3. P.633–636. https://doi.org/10.1111/j.1365-2133.2009.09593.xAugustin M., Glaeske G., Radtke M.A., Christophers E., Reich K., Schäfer I. Epidemiology and comorbidity of psoriasis in children. Br. J. Dermatol. 2010; 162(3):633–636. https://doi.org/10.1111/j.1365-2133.2009.09593.xDaudén E., Castañeda S., Suárez C., García-Campayo J., Blasco A.J., Aguilar M.D., Ferrándiz C., Puig L., Sánchez-Carazo J.L. Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis // J. Eur. Acad. Dermatol. Venereol. 2013. Vol.27, №11. P.1387–1404. https://doi.org/10.1111/jdv.12024Daudén E., Castañeda S., Suárez C., García-Campayo J., Blasco A.J., Aguilar M.D., Ferrándiz C., Puig L., Sánchez-Carazo J.L. Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis. J. Eur. Acad. Dermatol. Venereol. 2013; 27(11):1387–1404. https://doi.org/10.1111/jdv.12024Salihbegovic E.M., Hadzigrahic N., Suljagic E., Kurtalic N., Hadzic J., Zejcirovic A., Bijedic M., Handanagic A. Psoriasis and dyslipidemia // Mater. Sociomed. 2015. Vol.27, №1. P.15–17. https://doi.org/10.5455/msm.2014.27.15-17Salihbegovic E.M., Hadzigrahic N., Suljagic E., Kurtalic N., Hadzic J., Zejcirovic A., Bijedic M., Handanagic A. Psoriasis and dyslipidemia. Mater. Sociomed. 2015; 27(1):15–17. https://doi.org/10.5455/msm.2014.27.15-17Osigwe P.C., Agomoh C.E., Osigwe I.S. The association between psoriasis and atherosclerotic cardiovascular disease: a systematic review and meta-analysis of observational studies // Cureus. 2024. Vol.16, №6. Article number:e63379. https://doi.org/10.7759/cureus.63379Osigwe P.C., Agomoh C.E., Osigwe I.S. The association between psoriasis and atherosclerotic cardiovascular disease: a systematic review and meta-analysis of observational studies. Cureus 2024; 16(6):e63379. https://doi.org/10.7759/cureus.63379Coto-Segura P., Eiris-Salvado N., González-Lara L., Queiro-Silva R., Martinez-Camblor P., Maldonado-Seral C., García-García B., Palacios-García L., Gomez-Bernal S., Santos-Juanes J. Psoriasis, psoriatic arthritis and type 2 diabetes mellitus: a systematic review and meta-analysis // Br. J. Dermatol. 2013. Vol.169, №4. P.783–793. https://doi.org/10.1111/bjd.12473Coto-Segura P., Eiris-Salvado N., González-Lara L., Queiro-Silva R., Martinez-Camblor P., Maldonado-Seral C., García-García B., Palacios-García L., Gomez-Bernal S., Santos-Juanes J. Psoriasis, psoriatic arthritis and type 2 diabetes mellitus: A systematic review and meta-analysis. Br. J. Dermatol. 2013; 169(4):783–793. https://doi.org/10.1111/bjd.12473Armstrong A.W., Harskamp C.T., Armstrong E.J. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies // Nutr. Diabetes. 2012. Vol.2, №12. Article number:e54. https://doi.org/10.1038/nutd.2012.26Armstrong A.W., Harskamp C.T., Armstrong E.J. The association between psoriasis and obesity: A systematic review and meta-analysis of observational studies. Nutr. Diabetes 2012; 2(12):e54. https://doi.org/10.1038/nutd.2012.26Fu Y., Lee C.-H., Chi C.-C. Association of psoriasis with inflammatory bowel disease: a systematic review and meta-analysis // JAMA Dermatol. 2018. Vol.154, №12. P.1417–1423. https://doi.org/10.1001/jamadermatol.2018.3631Fu Y., Lee C.-H., Chi C.-C. Association of psoriasis with inflammatory bowel disease: a systematic review and meta-analysis. JAMA Dermatol. 2018; 154(12):1417–1423. https://doi.org/10.1001/jamadermatol.2018.3631Jing X., Zhuyuan W., Aijun C., Jianxia X., Kun H., Ping W. Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis // Front. Med. 2023. Vol.10. Article number:1175477. https://doi.org/10.3389/fmed.2023.1175477Jing X., Zhuyuan W., Aijun C., Jianxia X., Kun H, Ping W. Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis. Front. Med. 2023; 10:1175477. https://doi.org/10.3389/fmed.2023.1175477Rachakonda T.D., Schupp C.W., Armstrong A.W. Psoriasis prevalence among adults in the United States // J. Am. Acad. Dermatol. 2014. Vol.70, №3. P.512–516. https://doi.org/10.1016/j.jaad.2013.11.013Rachakonda T.D., Schupp C.W., Armstrong A.W. Psoriasis prevalence among adults in the United States. J. Am. Acad. Dermatol. 2014; 70( 3):512–516. https://doi.org/10.1016/j.jaad.2013.11.013Tanimura K., Nouraie S. M., Chandra D., Nyunoya T. Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure // J. Int. Med. Res. 2023. Vol.51, №6. Article number:3000605231182881. https://doi.org/10.1177/03000605231182881Tanimura K., Nouraie S.M., Chandra D., Nyunoya T. Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure. J. Int. Med. Res. 2023; 51(6):3000605231182881 https://doi.org/10.1177/03000605231182881Ishikawa G., Dua S., Mathur A., Acquah S.O., Salvatore M., Beasley M.B., Padilla M.L. Concomitant interstitial lung disease with psoriasis // Can. Respir. J. 2019. Vol.2019. Article number:5919304. https://doi.org/10.1155/2019/5919304Ishikawa G., Dua S., Mathur A., Acquah S.O., Salvatore M., Beasley M.B., Padilla M.L. Concomitant interstitial lung disease with psoriasis. Can. Respir. J. 2019; 2019:5919304. https://doi.org/10.1155/2019/5919304Козлов В.К., Лебедько О.А., Морозова Н.В., Пичугина С.В., Яковлев Е.И., Гандуров С.Г., Евсеева Г.П., Супрун С.В., Наговицына Е.Б., Кудерова Н.И. Хронические бронхолегочные заболевания у детей, протекающие с синдромом бронхиальной обструкции // Бюллетень физиологии и патологии дыхания. 2021. Вып.82. С.62–73. https://doi.org/10.36604/1998-5029-2021-82-62-73Kozlov V.K., Lebedko O.A., Morozova N.V., Pichugina S.V., Yakovlev E.I., Gandurov S.G., Evseeva G.P., Suprun S.V., Nagovitsyna E.B., Kuderova N.I. [Chronic bronchopulmonary diseases in children occurring with bronchial obstruction syndrome]. Bûlleten' fiziologii i patologii dyhaniâ = Bulletin Physiology and Pathology of Respiration 2021; 82:62– 73 (in Russian). https://doi.org/10.36604/1998-5029-2021-82-62-73Файрушина И.Ф., Кириллова Э.Р., Мухаметшина Э.И., Абдулганиева Д.И. Разнообразие коморбидной патологии у пациентов с псориатическим артритом молодого и среднего возраста // Вестник современной клинической медицины. 2021. Т.14, №1. С.47–52. https://doi.org/10.20969/VSKM.2021.14(1).47-52Fayrushina I.F., Kirillova E.R., Mukhametshina E.I., Abdulganieva D.I. [Diversity of comorbid pathology in patients with psoriatic arthritis of young and middle age]. Vestnik sovremennoy klinicheskoy meditsiny = The Bulletin of Contemporary Clinical Medicine 2021; 14(1):47–52 (in Russian). https://doi.org/10.20969/VSKM.2021.14 (1).47-52Кубанов А.А., Богданова Е.В. Эпидемиология псориаза в Российской Федерации (по данным регистра) // Вестник дерматологии и венерологии. 2022. Т.98, №2. С.33–41. https://doi.org/10.25208/vdv1268Kubanov A.A., Bogdanova E.V. [Epidemiology of psoriasis in the Russian Federation (according to the registry data)]. Vestnik Dermatologii i Venerologii 2022; 98(2):33–41 (in Russian). https://doi.org/10.25208/vdv1268Mleczko M., Gerkowicz A., Krasowska D. Chronic inflammation as the underlying mechanism of the development of lung diseases in psoriasis: a systematic review // Int. J. Mol. Sci. 2022. Vol.23, №3. Article number:1767. https://doi.org/10.3390/ijms23031767Mleczko M., Gerkowicz A., Krasowska D. Chronic inflammation as the underlying mechanism of the development of lung diseases in psoriasis: a systematic review. Int. J. Mol. Sci. 2022; 23(3):1767. https://doi.org/10.3390/ijms23031767Адаскевич В.П., Катина М.А. Клинические особенности псориаза у детей и подростков // Педиатрия. Consilium Medicum. 2018. №2. С.83–88. https://doi.org/10.26442/2413-8460_2018.2.83-88Adaskevich V.P., Katina М.А. [Clinical peculiarities of psoriasis in children and adolescents]. Pediatriya. Consilium Medicum = Pediatrics. Consilium Medicum 2018; 2:83–88 (in Russian). https://doi.org/10.26442/2413-8460_2018.2.83-88Galili E., Barzilai A., Twig G., Caspi T., Daniely D., Shreberk-Hassidim R., Astman N. Allergic rhinitis and asthma among adolescents with psoriasis: a population-based cross-sectional study // Acta Derm. Venereol. 2020. Vol.100, №10. Article number:adv00133.https://doi.org/10.2340/00015555-3485Galili E., Barzilai A., Twig G., Caspi T., Daniely D., Shreberk-Hassidim R., Astman N. Allergic rhinitis and asthma among adolescents with psoriasis: a population-based cross-sectional study. Acta Derm. Venereol. 2020; 100(10):adv00133. https://doi.org/10.2340/00015555-3485Ziyab A.H., Ali Y., Zein D., Al-Kandari M., Holloway J.W., Karmaus W. Association of psoriasis with allergic multimorbidity of asthma, rhinitis, and eczema among adolescents: a cross-sectional study // Allergy Asthma Clin. Immunol. 2024. Vol.20, №1. Article number:41. https://doi.org/10.1186/s13223-024-00907-6Ziyab A.H., Ali Y., Zein D., Al-Kandari M., Holloway J.W., Karmaus W. Association of psoriasis with allergic multimorbidity of asthma, rhinitis, and eczema among adolescents: a cross-sectional study. Allergy Asthma Clin. Immunol. 2024; 20(1):41. https://doi.org/10.1186/s13223-024-00907-6Клинические рекомендации. Хронический бронхит. М.: Российское респираторное общество, 2024. URL: https://cr.minzdrav.gov.ru/preview-cr/655_2[Clinical guidelines. Chronic bronchitis]. Moscow: Rossiyskoye respiratornoye obshchestvo; 2024 (in Russian). Available at: https://cr.minzdrav.gov.ru/preview-cr/655_2Коновалов К.М., Баранов А.А., Лапкина Н.А., Абайтова Н.Е., Борисова О.Л. Оценка активности иммуно-воспалительного процесса при ревматоидном артрите – клинические индексы и лабораторные маркеры: влияние инфекции COVID-19 // Пациентоориентированная медицина и фармация. 2025. Т.3, №1. С.49–58. https://doi.org/10.37489/2949-1924-0081Konovalov K.M., Baranov A.A., Lapkina N.A., Abaitova N.E., Borisova O.L. [Clinical indices and laboratory markers for evaluating the immune-mediated inflammation in rheumatoid arthritis: the impact of COVID-19]. Pacientoorientirovannaya medicina i farmaciya = Patient-oriented medicine and pharmacy 2025; 3(1):49–58 (in Russian). https://doi.org/10.37489/2949-1924-0081Mateu-Arrom L., Puig L. Genetic and epigenetic mechanisms of psoriasis // Genes (Basel). 2023. Vol.14, №8. Article number:1619. https://doi.org/10.3390/genes14081619Mateu-Arrom L., Puig L. Genetic and epigenetic mechanisms of psoriasis. Genes (Basel) 2023; 14:1619. https://doi.org/10.3390/ genes14081619Махмудова М. А. Эпигенетические механизмы в патогенезе аутоиммунных заболеваний // Экономика и социум. 2025. №3(130-2). С.618–620.Makhmudova M.A. [Epigenetic mechanisms in the pathogenesis of autoimmune diseases]. Ekonomika i sotsium 2025; 3(130-2):618–620 (in Russian).Reich K. The concept of psoriasis as a systemic inflammation: implications for disease management // J. Eur. Acad. Dermatol. Venereol. 2012. Vol.26, №S2. P.3–11. https://doi.org/10.1111/j.1468-3083.2011.04410.xReich K. The concept of psoriasis as a systemic inflammation: implications for disease management. J. Eur. Acad. Dermatol. Venereol. 2012; 26(Suppl.2):3–11. https://doi.org/10.1111/j.1468-3083.2011.04410.xAkbarzadeh R., Humrich J.Y., Nemeth T., Amber K.T. Editorial: Innate immune dysregulation: a driving force of autoimmunity and chronic inflammation // Front. Immunol. 2025. Vol.16. Article number:1632416. https://doi.org/10.3389/fimmu.2025.1632416Akbarzadeh R., Humrich J.Y., Nemeth T., Amber K.T. Editorial: Innate immune dysregulation: a driving force of autoimmunity and chronic inflammation. Front. Immunol. 2025; 16:1632416. https://doi.org/10.3389/fimmu.2025.1632416Sanchez A.P.G. Better understanding the immunopathogenesis of psoriasis // Clin. Res. Dermatol. Open Access. 2017. Vol.4, №1. P.1–2. http://dx.doi.org/10.15226/2378-1726/4/1/00151Sanchez A.P.G. Better understanding the immunopathogenesis of psoriasis. Clin. Res. Dermatol. Open Access 2017; 4(1):1–2. http://dx.doi.org/10.15226/2378-1726/4/1/00151Hawkes J.E., Chan T.C., Krueger J.G. Psoriasis pathogenesis and the development of novel targeted immune therapies // J. Allergy Clin. Immunol. 2017. Vol.140, №3. P.645–653. https://doi.org/10.1016/j.jaci.2017.06.010Hawkes J.E., Chan T.C., Krueger J.G. Psoriasis pathogenesis and the development of novel targeted immune therapies. J. Allergy Clin. Immunol. 2017; 140(3):645–653.https://doi.org/10.1016/j.jaci.2017.06.010Hawkes J.E., Yan B.Y., Chan T.C., Krueger J.G. Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis // J. Immunol. 2018. Vol.201, №6. P.1605–1613. https://doi.org/10.4049/jimmunol.1800013Hawkes J.E., Yan B.Y., Chan T.C., Krueger J.G. Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis. J. Immunol. 2018; 201(6):1605–1613. https://doi.org/10.4049/jimmunol.1800013Grän F., Kerstan A., Serfling E., Goebeler M., Muhammad K. Current developments in the immunology of psoriasis // Yale J. Biol. Med. 2020. Vol. 93, №1. P. 97–110.Grän F., Kerstan A., Serfling E., Goebeler M., Muhammad K. Current developments in the immunology of psoriasis. Yale J. Biol. Med. 2020; 93(1):97–110.von Stebut E., Boehncke W.H., Ghoreschi K., Gori T., Kaya Z., Thaci D. IL-17A in psoriasis and beyond: cardiovascular and metabolic implications // Front. Immunol. 2019. Vol.10. P.1–15. https://doi.org/10.3389/fimmu.2019.01686von Stebut E., Boehncke W.H., Ghoreschi K., Gori T., Kaya Z., Thaci D. IL-17A in psoriasis and beyond: cardiovascular and metabolic implications. Front. Immunol. 2019; 10:1–15. https://doi.org/10.3389/fimmu.2019.01686Krueger J.G., Brunner P.M. Interleukin-17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation, and associated comorbidities // Exp. Dermatol. 2017. Vol.27, №2. P.115–123. https://doi.org/10.1111/exd.13467Krueger J.G., Brunner P.M. Interleukin-17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation, and associated comorbidities. Exp. Dermatol. 2017; 27(1):115–123. https://doi.org/10.1111/exd.13467Matozzi C., Salvi M., D’Epiro S., Giancristoforo S., Macaluso L., Luci C. Importance of regulatory T cells in the pathogenesis of psoriasis: review of the literature // Dermatology. 2013. Vol.227, №2. P.134–145. https://doi.org/10.1159/000353398Matozzi C., Salvi M., D’Epiro S., Giancristoforo S., Macaluso L., Luci C. Importance of regulatory T cells in the pathogenesis of psoriasis: review of the literature. Dermatology 2013; 227(2):134–145. https://doi.org/10.1159/000353398Blauvelt A., Chiricozzi A. The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis // Clin. Rev. Allergy Immunol. 2018. Vol.55, №3. P.379–390. https://doi.org/10.1007/s12016-018-8702-3Blauvelt A., Chiricozzi A. The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis. Clin. Rev. Allergy Immunol. 2018; 55(3):379–390. https://doi.org/10.1007/s12016-018-8702-3Lin A.M., Rubin C.J., Khandpur R., Wang J.Y., Riblett M., Yalavarthi S., Villanueva E.C. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis // J. Immunol. 2011. Vol.187, №1. P.490–500. https://doi.org/10.4049/jimmunol.1100123Lin A.M., Rubin C.J., Khandpur R., Wang J.Y., Riblett M., Yalavarthi S., Villanueva E.C. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J. Immunol. 2011; 187(1):490–500. https://doi.org/10.4049/jimmunol.1100123Benezeder T., Wolf P. Resolution of plaque-type psoriasis: what is left behind (and reinitiates the disease) // Semin. Immunopathol. 2019. Vol.41, №6. P.633–644. https://doi.org/10.1007/s00281-019-00766-zBenezeder T., Wolf P. Resolution of plaque-type psoriasis: what is left behind (and reinitiates the disease). Semin. Immunopathol. 2019; 41(6):633–644. https://doi.org/10.1007/s00281-019-00766-zDiani M., Altomare G., Reali E. T helper cell subsets in clinical manifestations of psoriasis // J. Immunol. Res. 2016. Vol.2016. Article number:7692024. https://doi.org/10.1155/2016/7692024Diani M., Altomare G., Reali E. T helper cell subsets in clinical manifestations of psoriasis. J. Immunol. Res. 2016; 2016:7692024. https://doi.org/10.1155/2016/7692024Ray A., Kolls J.K. Neutrophilic inflammation in asthma and association with disease severity // Trends Immunol. 2017. Vol.38, №12. P.942–954. https://doi.org/10.1016/j.it.2017.07.003Ray A., Kolls J.K. Neutrophilic inflammation in asthma and association with disease severity. Trends Immunol. 2017; 38(12): 942–954. https://doi.org/10.1016/j.it.2017.07.003Urbanowicz R.A., Lamb J.R., Todd I., Corne J.M., Fairclough L.C. Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients // Respir. Res. 2010. Vol.11. Article number:76. https://doi.org/10.1186/1465-9921-11-76Urbanowicz R.A., Lamb J.R., Todd I., Corne J.M., Fairclough L.C. Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients. Respir. Res. 2010; 11:76. https://doi.org/10.1186/1465-9921-11-76Di Stefano A., Caramori G., Gnemmi I., Contoli M., Vicari C., Capelli A., Magno F., D’Anna S.E., Zanini A., Brun P. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients // Clin. Exp. Immunol. 2009. Vol.157, №2. P.316–324. https://doi.org/10.1111/j.1365-2249.2009.03965.xDi Stefano A., Caramori G., Gnemmi I., Contoli M., Vicari C., Capelli A., Magno F., D’Anna S.E., Zanini A., Brun P. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin. Exp. Immunol. 2009; 157(2):316–324. https://doi.org/10.1111/j.1365-2249.2009.03965.xFacco M., Cabrelle A., Teramo A., Olivieri V., Gnoato M., Teolato S., Ave E., Gattazzo C., Fadini G.P., Calabrese F. Sarcoidosis is a Th1/Th17 multisystem disorder // Thorax. 2011. Vol.66, №2. P.144–150. https://doi.org/10.1136/thx.2010.140319Facco M., Cabrelle A., Teramo A., Olivieri V., Gnoato M., Teolato S., Ave E., Gattazzo C., Fadini G.P., Calabrese F. Sarcoidosis is a Th1/Th17 multisystem disorder. Thorax 2011; 66(2):144–150. https://doi.org/10.1136/thx.2010.140319Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Pagé N., Olivenstein R., Elias J., Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines // J. Allergy Clin. Immunol. 2001. Vol.108, №3. P.430–438. https://doi.org/10.1067/mai.2001.117929Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Pagé N., Olivenstein R., Elias J., Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 2001; 108(3):430–438. https://doi.org/10.1067/mai.2001.117929Hellermann G.R., Nagy S.B., Kong X., Lockey R.F., Mohapatra S.S. Mechanism of cigarette smoke condensateinduced acute inflammatory response in human bronchial epithelial cells // Respir. Res. 2002. Vol.3. Article number:22. https://doi.org/10.1186/rr166Hellermann G.R., Nagy S.B., Kong X., Lockey R.F., Mohapatra S.S. Mechanism of cigarette smoke condensateinduced acute inflammatory response in human bronchial epithelial cells. Respir. Res. 2002; 3:22. https://doi.org/10.1186/rr166Ma W.-J., Sun Y.-H., Jiang J.-X., Dong X.-W., Zhou J.-Y., Xie Q.-M. Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells // Prostaglandins Leukot. Essent. Fat. Acids. 2015. Vol.94. P.13–19. https://doi.org/10.1016/j.plefa.2014.11.005Ma W.-J., Sun Y.-H., Jiang J.-X., Dong X.-W., Zhou J.-Y., Xie Q.-M. Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells. Prostaglandins Leukot. Essent. Fat. Acids 2015; 94:13–19. https://doi.org/10.1016/j.plefa.2014.11.005Keatings V.M., Collins P.D., Scott D.M., Barnes P.J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma // Am. J. Respir. Crit. Care Med. 1996. Vol.153, №1. P.530–534. https://doi.org/10.1164/ajrccm.153.2.8564092Keatings V.M., Collins P.D., Scott D.M., Barnes P.J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am. J. Respir. Crit. Care Med. 1996; 153(1):530–534. https://doi.org/10.1164/ajrccm.153.2.8564092Elder J.T. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis // Genes Immun. 2009. Vol.10, №3. P.201–209. https://doi.org/10.1038/gene.2009.11Elder J.T. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. Genes Immun. 2009; 10(3): 201–209. https://doi.org/10.1038/gene.2009.11Weidinger S., Willis-Owen S.A.G., Kamatani Y., Baurecht H., Morar N., Liang L., Edser P., Street T., Rodriguez E., O’Regan G.M. A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis // Hum. Mol. Genet. 2013. Vol.22, №23. P.4841–4856. https://doi.org/10.1093/hmg/ddt317Weidinger S., Willis-Owen S.A.G., Kamatani Y., Baurecht H., Morar N., Liang L., Edser P., Street T., Rodriguez E., O’Regan G.M. A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum. Mol. Genet. 2013; 22(23): 4841–4856. https://doi.org/10.1093/hmg/ddt317Kere J. Mapping and identifying genes for asthma and psoriasis // Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2005. Vol.360, №1460. P.1551–1561. https://doi.org/10.1098/rstb.2005.1684Kere J. Mapping and identifying genes for asthma and psoriasis. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2005; 360(1460):1551–1561. https://doi.org/10.1098/rstb.2005.1684Tanimura K., Aldrich M.C., Jaworski J., Xing J., Okawa S., Chandra D., Nouraie S.M., Nyunoya T. Identifying a genetic link between lung function and psoriasis // Ann. Hum. Genet. 2025. Vol.89, №2-3. P.89–95. https://doi.org/10.1111/ahg.12587Tanimura K., Aldrich M.C., Jaworski J., Xing J., Okawa S., Chandra D., Nouraie S.M., Nyunoya T. Identifying a genetic link between lung function and psoriasis. Ann. Hum. Genet. 2025; 89(2-3):89–95. https://doi.org/10.1111/ahg.12587Östling J., van Geest M., Schofield J.P.R., Jevnikar Z., Wilson S., Ward J., Lutter R., Shaw D.E., Bakke P.S., Caruso M. IL-17-high asthma with features of a psoriasis immunophenotype // J. Allergy Clin. Immunol. 2019. Vol.144, №5. P.1198–1213. https://doi.org/10.1016/j.jaci.2019.03.027Östling J., van Geest M., Schofield J.P.R., Jevnikar Z., Wilson S., Ward J., Lutter R., Shaw D.E., Bakke P.S., Caruso M. IL-17-high asthma with features of a psoriasis immunophenotype. J. Allergy Clin. Immunol. 2019; 144(5): 1198–1213. https://doi.org/10.1016/j.jaci.2019.03.027Hollox E.J., Huffmeier U., Zeeuwen P.L.J.M., Palla R., Lascorz J., Rodijk-Olthuis D., van de Kerkhof P.C.M., Traupe H., de Jongh G., den Heijer M. Psoriasis is associated with increased beta-defensin genomic copy number // Nat. Genet. 2008. Vol.40, №1. P.23–25. https://doi.org/10.1038/ng.2007.48Hollox E.J., Huffmeier U., Zeeuwen P.L.J.M., Palla R., Lascorz J., Rodijk-Olthuis D., van de Kerkhof P.C.M., Traupe H., de Jongh G., den Heijer M. Psoriasis is associated with increased beta-defensin genomic copy number. Nat. Genet. 2008; 40(1):23–25. https://doi.org/10.1038/ng.2007.48Janssens W., Nuytten H., Dupont L.J., Van Eldere J., Vermeire S., Lambrechts D., Nackaerts K., Decramer M., Cassiman J.-J., Cuppens H. Genomic copy number determines functional expression of β-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease // Am. J. Respir. Crit. Care Med. 2010. Vol.182, №2. P.163–169. https://doi.org/10.1164/rccm.200905-0767OCJanssens W., Nuytten H., Dupont L.J., Van Eldere J., Vermeire S., Lambrechts D., Nackaerts K., Decramer M., Cassiman J.-J., Cuppens H. Genomic copy number determines functional expression of β-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2010; 182(2):163–169. https://doi.org/10.1164/rccm.200905-0767OCNair R.P., Duffin K.C., Helms C., Ding J., Stuart P.E., Goldgar D., Gudjonsson J.E., Li Y., Tejasvi T., Feng B.-J. Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways // Nat. Genet. 2009. Vol.41, №2. P.199–204. https://doi.org/10.1038/ng.311Nair R.P., Duffin K.C., Helms C., Ding J., Stuart P.E., Goldgar D., Gudjonsson J.E., Li Y., Tejasvi T., Feng B.-J. Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways. Nat. Genet. 2009; 41(2):199–204. https://doi.org/10.1038/ng.311Kim H.S., Choi D., Lim L.L., Allada G., Smith J.R., Austin C.R., Doyle T.M., Goodwin K.A., Rosenbaum J.T., Martin T.M. Association of interleukin 23 receptor gene with sarcoidosis // Dis. Markers. 2011. Vol.31, №1. P.17–24. https://doi.org/10.1155/2011/185106Kim H.S., Choi D., Lim L.L., Allada G., Smith J.R., Austin C.R., Doyle T.M., Goodwin K.A., Rosenbaum J.T., Martin T.M. Association of interleukin 23 receptor gene with sarcoidosis. Dis. Markers 2011; 31(1):17–24. https://doi.org/10.1155/2011/185106Lateef O., Shakoor N., Balk R.A. Methotrexate pulmonary toxicity // Expert Opin. Drug Saf. 2005. Vol.4, №4. P.723–730. https://doi.org/10.1517/14740338.4.4.723Lateef O., Shakoor N., Balk R.A. Methotrexate pulmonary toxicity. Expert Opin. Drug Saf. 2005; 4(4):723–730. https://doi.org/10.1517/14740338.4.4.723Hünür M., Öğüt T.S., Çelik E., Erbasan F., Dilbil M., Nokay M. Lung involvement in patients with psoriatic arthritis // Arch. Rheumatol. 2024. Vol.39, №4. P.631–640. https://doi.org/10.46497/ArchRheumatol.2024.10537Hünür M., Öğüt T.S., Çelik E., Erbasan F., Dilbil M., Nokay M. Lung involvement in patients with psoriatic arthritis. Arch. Rheumatol. 2024; 39(4):631–640. https://doi.org/10.46497/ArchRheumatol.2024.10537Nadarajan P., Fabre A., Kelly E. Sulfasalazine: a rare cause of acute eosinophilic pneumonia // Respir. Med. Case Rep. 2016. Vol.18. P.35–36. https://doi.org/10.1016/j.rmcr.2016.03.006Nadarajan P., Fabre A., Kelly E. Sulfasalazine: a rare cause of acute eosinophilic pneumonia. Respir. Med. Case Rep. 2016; 18:35–36. https://doi.org/10.1016/j.rmcr.2016.03.006Kamata M., Tada Y. Efficacy and safety of biologics for psoriasis and psoriatic arthritis and their impact on comorbidities: a literature review // Int. J. Mol. Sci. 2020. Vol.21, №5. Article number:1690. https://doi.org/10.3390/ijms21051690Kamata M., Tada Y. Efficacy and safety of biologics for psoriasis and psoriatic arthritis and their impact on comorbidities: a literature review. Int. J. Mol. Sci. 2020; 21(5):1690. https://doi.org/10.3390/ijms21051690Yiu Z.Z.N., Smith C.H., Ashcroft D.M., Lunt M., Walton S., Murphy R., Reynolds N.J., Ormerod A.D., Griffiths C.E.M., Warren R.B. Risk of serious infection in patients with psoriasis receiving biologic therapies: a prospective cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR) // J. Investig. Dermatol. 2018. Vol.138, №3. P.534–541. https://doi.org/10.1016/j.jid.2017.10.005Yiu Z.Z.N., Smith C.H., Ashcroft D.M., Lunt M., Walton S., Murphy R., Reynolds N.J., Ormerod A.D., Griffiths C.E.M., Warren R.B. Risk of serious infection in patients with psoriasis receiving biologic therapies: a prospective cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). J. Investig. Dermatol. 2018; 138(3):534–541. https://doi.org/10.1016/j.jid.2017.10.005Goujdami N., Haij K., Ezzine J., Lairani F., Nacir O., Ait Errami A., Oubaha S., Samlani Z., Krati K. Asthma development under adalimumab therapy: a clinical case analysis // SAS J. Med. 2024. Vol.10, №10. P.1043–1045. https://doi.org/10.36347/sasjm.2024.v10i10.008Goujdami N., Haij K., Ezzine J., Lairani F., Nacir O., Ait Errami A., Oubaha S., Samlani Z., Krati K. Asthma development under adalimumab therapy: a clinical case analysis. SAS J. Med. 2024; 10(10):1043–1045. https://doi.org/10.36347/sasjm.2024.v10i10.008Eren Dagli C., Akgedik R., Yildirim B.B., Gunaydin R. Adalimumab and etanercept induced asthma // Eur. Respir. J. 2015. Vol.46. Article number:650. https://doi.org/10.1183/13993003.congress-2015.PA650Eren Dagli C., Akgedik R., Yildirim B.B., Gunaydin R. Adalimumab and etanercept induced asthma. Eur. Respir. J. 2015; 46:650. https://doi.org/10.1183/13993003.congress-2015.PA650Herrinton L.J., Harrold L.R., Liu L., Raebel M.A., Taharka A., Winthrop K.L., Solomon D.H., Curtis J.R., Lewis J.D., Saag K.G. Association between anti-TNF-α therapy and interstitial lung disease // Pharmacoepidemiol. Drug Saf. 2013. Vol.22, №4. P.394–402. https://doi.org/10.1002/pds.3409Herrinton L.J., Harrold L.R., Liu L., Raebel M.A., Taharka A., Winthrop K.L., Solomon D.H., Curtis J.R., Lewis J.D., Saag K.G. Association between anti-TNF-α therapy and interstitial lung disease. Pharmacoepidemiol. Drug Saf. 2013; 22(4):394–402. https://doi.org/10.1002/pds.3409Campa M., Mansouri B., Warren R., Menter A. A review of biologic therapies targeting IL-23 and IL-17 for use in moderate-to-severe plaque psoriasis // Dermatol. Ther. 2016. Vol.6, №1. P.1–12. https://doi.org/10.1007/s13555-015-0092-3Campa M., Mansouri B., Warren R., Menter A. A review of biologic therapies targeting il-23 and il-17 for use in moderate-to-severe plaque psoriasis. Dermatol. Ther. 2016; 6(1):1–12. https://doi.org/10.1007/s13555-015-0092-3Durham A.L., Caramori G., Chung K.F., Adcock I.M. Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease // Transl. Res. 2016. Vol.167, №1. P.192–203. https://doi.org/10.1016/j.trsl.2015.08.004Durham A.L., Caramori G., Chung K.F., Adcock I.M. Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease. Transl. Res. 2016; 167(1):192–203. https://doi.org/10.1016/j.trsl.2015.08.004Choy D.F., Hart K.M., Borthwick L.A., Shikotra A., Nagarkar D.R., Siddiqui S., Jia G., Ohri C.M., Doran E., Vannella K.M. Th2 and Th17 inflammatory pathways are reciprocally regulated in asthma // Sci. Transl. Med. 2015. Vol.7, №301. Article number:301ra129. https://doi.org/10.1126/scitranslmed.aab3142Choy D.F., Hart K.M., Borthwick L.A., Shikotra A., Nagarkar D.R., Siddiqui S., Jia G., Ohri C.M., Doran E., Vannella K.M. Th2 and Th17 inflammatory pathways are reciprocally regulated in asthma. Sci. Transl. Med. 2015; 7(301):301ra129. https://doi.org/10.1126/scitranslmed.aab3142Bhavani S., Tsai C.-L., Perusich S., Hesselbacher S., Coxson H., Pandit L., Corry D.B., Kheradmand F. Clinical and immunological factors in emphysema progression. Five-year prospective longitudinal exacerbation study of chronic obstructive pulmonary disease (LES-COPD) // Am. J. Respir. Crit. Care Med. 2015. Vol.192, №10. P.1171–1178. https://doi.org/10.1164/rccm.201504-0736OCBhavani S., Tsai C.-L., Perusich S., Hesselbacher S., Coxson H., Pandit L., Corry D.B., Kheradmand F. Clinical and immunological factors in emphysema progression. Five-year prospective longitudinal exacerbation study of chronic obstructive pulmonary disease (LES-COPD). Am. J. Respir. Crit. Care Med. 2015; 192(10):1171–1178. https://doi.org/10.1164/rccm.201504-0736OCWilson M.S., Madala S.K., Ramalingam T.R., Gochuico B.R., Rosas I.O., Cheever A.W., Wynn T.A. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent // J. Exp. Med. 2010. Vol.207, №3. P.535–552. http s://doi.org/10.1084/jem.20092121Wilson M.S., Madala S.K., Ramalingam T.R., Gochuico B.R., Rosas I.O., Cheever A.W., Wynn T.A. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J. Exp. Med. 2010; 207(3):535–552. https://doi.org/10.1084/jem.20092121

The authors declare that there are no conflicts of interest present.