cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2026-100-46-55cfpd-1342Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHКлинико-лабораторные маркеры оценки инсулинорезистентности у пациентов с лёгкой степенью обструктивного апноэ во снеClinical and laboratory markers for assessing insulin resistance in patients with mild obstructive sleep apneahttps://orcid.org/0009-0007-5964-7051БоровицкийВ. С.BorovitskyV. S.

Владислав Семёнович Боровицкий, д-р мед. наук, главный научный сотрудник

125130, Москва, ул. Нарвская, 15а, стр. 1 

Vladislav S. Borovitsky, MD, PhD, DSc (Med.), Main Staff Scientist 

building 1, 15a Narvskaya Str., Moscow, 125130

qwertyuiop54@yandex.ruhttps://orcid.org/0000-0002-6571-1220БабакС. Л.BabakS. L.

Сергей Львович Бабак, д-р мед. наук, доцент, врач-пульмонолог, профессор кафедры фтизиатрии и пульмонологии Научно-образовательного института клинической медицины им. Н.А. Семашко

127006, Москва, ул. Долгоруковская, 4 

Sergey L. Babak, MD, PhD, DSc (Med.), Associate Professor, Pulmonologist, Professor of the Department of Phthisiology and Pulmonology of the N.A. Semashko

4 Dolgorukovskaya Str., Moscow, 127006 

sergbabak@mail.ruhttps://orcid.org/0000-0002-2039-0072ГорбуноваМ. В.GorbunovaM. V.

Марина Валентиновна Горбунова, д-р мед. наук, врач-пульмонолог, доцент кафедры фтизиатрии и пульмонологии Научно-образовательного института клинической медицины им. Н.А. Семашко

127006, Москва, ул. Долгоруковская, 4 

Marina V. Gorbunova, MD, PhD, DSc (Med.), Pulmonologist, Associate Professor of the Department of Phthisiology and Pulmonology, N.A. Semashko 

4 Dolgorukovskaya Str., Moscow, 127006 

mgorb@mail.ruФедеральное казённое учреждение «Научно-исследовательский институт Федеральной службы исполнения наказаний»Federal State Institution "Research Institute of the Federal Penitentiary Service"Федеральное государственное бюджетное образовательное учреждение высшего образования «Российский университет медицины» Минздрава РоссииFederal State Budgetary Educational Institution of Higher Education "Russian University of Medicine" of the Ministry of Health of the Russian Federation20261606202601004655Copyright © Боровицкий В.С., Бабак С.Л., Горбунова М.В., 20262026Боровицкий В.С., Бабак С.Л., Горбунова М.В.Borovitsky V.S., Babak S.L., Gorbunova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/1342Цель

Цель. На основании анализа клинических и инструментальных данных у пациентов с обструктивным апноэ сна (ОАС) лёгкой степени (n = 102) выявить маркеры, ассоциированные с инсулинорезистентностью, и оценить их прогностическую значимость.

Материалы и методы

Материалы и методы. В ретроспективное исследование включены 102 мужчины 30–55 лет (44 [40–50]) с ОАС лёгкой степени (ИАГ ≥5 и <15/ч) и метаболическими нарушениями, обследованные в 2018–2020 гг. Выявление маркеров инсулинорезистентности проводили методом простой логистической регрессии с пошаговым включением и исключением предикторов.

Результаты

Результаты. Наиболее информативными признаками инсулинорезистентности у пациентов с лёгкой степенью ОАС были: избыточная дневная сонливость ≥9 баллов, ИАГ ≥11/ч, индекс ночных десатураций ≥3,6/ч, время с сатурацией менее 90% ≥0,9% времени сна, средняя ночная сатурация ≤94%, минимальная ночная сатурация ≤85%, максимальная ночная ЧСС ≥95/мин и индекс реактивной гиперемии ≤1,7.

Заключение

Заключение. Полученные показатели могут рассматриваться как доступные маркеры инсулинорезистентности при лёгкой степени ОАС.

Aim

Aim. Based on the analysis of clinical and instrumental data in patients with mild obstructive sleep apnea (OSA) (n = 102), to identify markers associated with insulin resistance and evaluate their prognostic significance.

Materials and methods

Materials and methods. The retrospective study included 102 men aged 30–55 years (median 44 [40–50]) with mild OSA (apneahypopnea index [AHI] ≥5 and <15 events/hour) and metabolic disorders, examined between 2018 and 2020. Markers of insulin resistance were identified using simple logistic regression with stepwise inclusion and exclusion of predictors.

Results

Results. The most informative indicators of insulin resistance in patients with mild OSA were: excessive daytime sleepiness ≥9 points; AHI ≥11/hour; nocturnal desaturation index ≥3.6/hour; time spent with oxygen saturation below 90% ≥0.9% of total sleep time; mean nocturnal oxygen saturation ≤94%; minimum nocturnal oxygen saturation ≤85%; maximum nocturnal heart rate ≥95 bpm; and reactive hyperemia index ≤1.7.

Conclusion

Conclusion. These parameters may be considered accessible markers of insulin resistance in patients with mild OSA.

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The authors declare that there are no conflicts of interest present.