cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.12737/article_5c1278d242a333.68376622cfpd-162Research ArticleСтатьиРЕЦЕПТОРЫ ПРОГЕСТЕРОНА: РЕПРОДУКТИВНАЯ РОЛЬPROGESTERONE RECEPTORS: A REPRODUCTIVE ROLEДовжиковаИ. В.DovzhikovaI. V.noemail@neicon.ruАндриевскаяИ. А.AndrievskayaI. A.noemail@neicon.ruПетроваК. К.PetrovaK. K.noemail@neicon.ruДальневосточный научный центр физиологии и патологии дыханияFar Eastern Scientific Center of Physiology and Pathology of Respiration201818112019070104112Copyright © Довжикова И.В., Андриевская И.А., Петрова К.К., 20192019Довжикова И.В., Андриевская И.А., Петрова К.К.Dovzhikova I.V., Andrievskaya I.A., Petrova K.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/162

В статье представлены современные данные о механизме действия прогестерона. Рассмотрены геномные и негеномные способы действия гормона, осуществляющиеся через разные виды рецепторов: ядерных и мембранно-ассоциированных. Помимо этого описаны вспомогательные белки, важную роль, в функционировании которых играет связывание АТФ. Подчеркнуто, что специфические эффекты прогестерона в различных тканях зависят от набора рецепторов и их корегуляторов. Особое внимание уделено функции рецепторов прогестерона в эндометрии и миометрии. Обобщены результаты исследования рецепторов прогестерона в плаценте. Сделан вывод о необходимости дальнейшего исследования рецепторов прогестерона при осложненной беременности, сопровождающейся недостатком реализации прогестероновых эффектов.

The article presents modern data on the mechanism of progesterone action. Genomic and non-genomic ways of hormone action realized through different types of receptors (nuclear and membrane-associated) are considered. In addition, auxiliary proteins are described; in their functioning ATP binding plays an important role. It is emphasized that the specific effects of progesterone in various tissues depend on the set of receptors and their co-regulators. A special emphasis is made on the functions of the progesterone receptors in the endometrium and myometrium. The results of the study of progesterone receptors in placenta are summarized. It was concluded that there is a necessity in the further research of progesterone receptors in complicated pregnancy with a decrease in the implementation of progesterone effects.

прогестеронрецептор прогестеронамеханизм действия прогестеронабеременностьплацентаprogesteroneprogesterone receptormechanism of progesterone actionpregnancyplacentaReferencesДовжикова И.В. Прогестерон в плаценте при беременности, осложненной обострением герпес-вирусной инфекции // Фундаментальные исследования. 2010. №4. С.44-49.Довжикова И.В. Прогестерон в плаценте при беременности, осложненной обострением герпес-вирусной инфекции // Фундаментальные исследования. 2010. №4. С.44-49.Репина М.А. Прогестерон и беременность // Журнал акушерства и женских болезней. 2011. T.LX, Вып.3. С.130-135.Репина М.А. Прогестерон и беременность // Журнал акушерства и женских болезней. 2011. T.LX, Вып.3. С.130-135.Blanton M.P., Xie Y., Dangott L.J., Cohen J.B. The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface // Mol. Pharmacol. 1999. Vol.55, №2. Р.269-278.Blanton M.P., Xie Y., Dangott L.J., Cohen J.B. The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface // Mol. Pharmacol. 1999. Vol.55, №2. Р.269-278.Brinton R.D., Thompson R.F., Foy M.R., Baudry M., Wang J., Finch C.E., Morgan T.E., Pike C.J., Mack W.J., Stanczyk F.Z., Nilsen J. Progesterone receptors: form and function in brain // Front. Neuroendocrinol. 2008. Vol.29, №2. Р.313-339.Brinton R.D., Thompson R.F., Foy M.R., Baudry M., Wang J., Finch C.E., Morgan T.E., Pike C.J., Mack W.J., Stanczyk F.Z., Nilsen J. Progesterone receptors: form and function in brain // Front. Neuroendocrinol. 2008. Vol.29, №2. Р.313-339.Cobos E.J., Entrena J.M., Nieto F.R., Cendán C.M., Del Pozo E. Pharmacology and therapeutic potential of sigma (1) receptor ligands // Curr. Neuropharmacol. 2008. Vol.6, №4. Р.344-366. doi: 10.2174/157015908787386113Cobos E.J., Entrena J.M., Nieto F.R., Cendán C.M., Del Pozo E. Pharmacology and therapeutic potential of sigma (1) receptor ligands // Curr. Neuropharmacol. 2008. Vol.6, №4. Р.344-366. doi: 10.2174/157015908787386113Conneely O.M., Mulac-Jericevic B., DeMayo F., Lydon J.P., O'Malley B.W. Reproductive functions of progesterone receptors // Recent. Prog. Horm. Res. 2002. Vol.57. P.339-355.Conneely O.M., Mulac-Jericevic B., DeMayo F., Lydon J.P., O'Malley B.W. Reproductive functions of progesterone receptors // Recent. Prog. Horm. Res. 2002. Vol.57. P.339-355.Conneely O.M., Mulac-Jericevic B., Lydon J.P. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms // Steroids. 2003. Vol.68, №10-13. Р.771-778.Conneely O.M., Mulac-Jericevic B., Lydon J.P. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms // Steroids. 2003. Vol.68, №10-13. Р.771-778.Davies T.H., Ning Y.M., Sánchez E.R. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins // J. Biol. Chem. 2002. Vol.277, №7. Р.4597-4600.Davies T.H., Ning Y.M., Sánchez E.R. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins // J. Biol. Chem. 2002. Vol.277, №7. Р.4597-4600.Dosiou C., Hamilton A.E., Pang Y., Overgaard M.T., Tulac S., Dong J., Thomas P., Giudice L.C. Expression of membrane progesterone receptors of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone // J. Endocrinol. 2008. Vol.196, №1. Р.67-77.Dosiou C., Hamilton A.E., Pang Y., Overgaard M.T., Tulac S., Dong J., Thomas P., Giudice L.C. Expression of membrane progesterone receptors of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone // J. Endocrinol. 2008. Vol.196, №1. Р.67-77.Fernandes M.S., Pierron V., Michalovich D., Astle S., Thornton S., Peltoketo H., Lam E.W., Gellersen B., Huhtaniemi I., Allen J., Brosens J.J. Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues // J. Endocrinol. 2005. Vol.187, №1. Р.89-101. doi:10.1677/joe.1.06242Fernandes M.S., Pierron V., Michalovich D., Astle S., Thornton S., Peltoketo H., Lam E.W., Gellersen B., Huhtaniemi I., Allen J., Brosens J.J. Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues // J. Endocrinol. 2005. Vol.187, №1. Р.89-101. doi:10.1677/joe.1.06242Garbus I., Bouzat C., Barrantes F.J. Steroids differentially inhibit the nicotinic acetylcholine receptor // Neuroreport. 2001. Vol.12, №2. Р.227231.Garbus I., Bouzat C., Barrantes F.J. Steroids differentially inhibit the nicotinic acetylcholine receptor // Neuroreport. 2001. Vol.12, №2. Р.227231.Gellersen B., Fernandes M.S., Brosens J.J. Non-genomic progesterone actions in female reproduction // Hum. Reprod. Update. 2009. Vol.15, №1. Р.119-138. doi: 10.1093/humupd/dmn044Gellersen B., Fernandes M.S., Brosens J.J. Non-genomic progesterone actions in female reproduction // Hum. Reprod. Update. 2009. Vol.15, №1. Р.119-138. doi: 10.1093/humupd/dmn044Guennoun R., Labombarda F., Gonzalez Deniselle M.C., Liere P., De Nicola A.F., Schumacher M. Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection // J. Steroid Biochem. Mol. Biol. 2015. Vol.146. Р.48-61. doi: 10.1016/j.jsbmb.2014.09.001Guennoun R., Labombarda F., Gonzalez Deniselle M.C., Liere P., De Nicola A.F., Schumacher M. Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection // J. Steroid Biochem. Mol. Biol. 2015. Vol.146. Р.48-61. doi: 10.1016/j.jsbmb.2014.09.001Hagan C.R., Daniel A.R., Dressing G.E., Lange C.A. Role of phosphorylation in progesterone receptor signaling and specificity // Mol. Cell. Endocrinol. 2012. Vol.357. Р.43-49.Hagan C.R., Daniel A.R., Dressing G.E., Lange C.A. Role of phosphorylation in progesterone receptor signaling and specificity // Mol. Cell. Endocrinol. 2012. Vol.357. Р.43-49.Hasegawa S., Kasubuchi M., Terasawa K., Kimura I. Perspectives on membrane-associated progesterone receptors as prospective therapeutic targets. // Curr. Drug. Targets. 2016. Vol.17, №10. Р.1189-1197.Hasegawa S., Kasubuchi M., Terasawa K., Kimura I. Perspectives on membrane-associated progesterone receptors as prospective therapeutic targets. // Curr. Drug. Targets. 2016. Vol.17, №10. Р.1189-1197.Hernández M.P., Sullivan W.P., Toft D.O. The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex // J. Biol. Chem. 2002. Vol.277, №41. Р.38294-38304.Hernández M.P., Sullivan W.P., Toft D.O. The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex // J. Biol. Chem. 2002. Vol.277, №41. Р.38294-38304.Hickman T.N., Shih L.M., Zacur H.A., Kurman R.J., Diener-West M., Gearhart J.D. Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortions // Fertil. Steril. 2002. Vol.77, №5. Р.1001-1005.Hickman T.N., Shih L.M., Zacur H.A., Kurman R.J., Diener-West M., Gearhart J.D. Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortions // Fertil. Steril. 2002. Vol.77, №5. Р.1001-1005.Jacobsen B.M., Horwitz K.B. Progesterone receptors, their isoforms and progesterone regulated transcription // Mol. Cell. Endocrinol. 2012. Vol.357, №1-2. Р.18-29. doi: 10.1016/j.mce.2011.09.016Jacobsen B.M., Horwitz K.B. Progesterone receptors, their isoforms and progesterone regulated transcription // Mol. Cell. Endocrinol. 2012. Vol.357, №1-2. Р.18-29. doi: 10.1016/j.mce.2011.09.016Karteris E., Zervou S., Pang Y., Dong J., Hillhouse E.W., Randeva H.S., Thomas P. Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term // Mol. Endocrinol. 2006. Vol.20, №7. Р.1519-1534.Karteris E., Zervou S., Pang Y., Dong J., Hillhouse E.W., Randeva H.S., Thomas P. Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term // Mol. Endocrinol. 2006. Vol.20, №7. Р.1519-1534.Khan-Dawood F.S., Dawood M.Y. Estrogen and progesterone receptor and hormone levels in human myometrium and placenta in term pregnancy // Am. J. Obstet. Gynecol. 1984. Vol.150, №5 (Pt1). Р.501-505.Khan-Dawood F.S., Dawood M.Y. Estrogen and progesterone receptor and hormone levels in human myometrium and placenta in term pregnancy // Am. J. Obstet. Gynecol. 1984. Vol.150, №5 (Pt1). Р.501-505.Kimura I., Nakayama Y., Konishi M., Terasawa K., Ohta M., Itoh N., Fujimoto M. Functions of MAPR (membrane-associated progesterone receptor) family members as heme/steroid-binding proteins // Curr. Protein Pept. Sci. 2012. Vol.13, №7. Р. 687-696. doi: 10.2174/138920312804142110Kimura I., Nakayama Y., Konishi M., Terasawa K., Ohta M., Itoh N., Fujimoto M. Functions of MAPR (membrane-associated progesterone receptor) family members as heme/steroid-binding proteins // Curr. Protein Pept. Sci. 2012. Vol.13, №7. Р. 687-696. doi: 10.2174/138920312804142110Ko L.,Cardona G.R., Henrion-Caude A., Chin W.W. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors // Mol. Cell. Biol. 2002. Vol.22, №1. Р. 357-369.Ko L.,Cardona G.R., Henrion-Caude A., Chin W.W. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors // Mol. Cell. Biol. 2002. Vol.22, №1. Р. 357-369.Large M.J., DeMayo F.J. The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling // Mol. Cell. Endocrinol. 2012. Vol.358, №2. Р.155-165. doi: 10.1016/j.mce.2011.07.027Large M.J., DeMayo F.J. The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling // Mol. Cell. Endocrinol. 2012. Vol.358, №2. Р.155-165. doi: 10.1016/j.mce.2011.07.027Li X., O'Malley B.W. Unfolding the action of progesterone receptors // J. Biol. Chem. 2003. Vol.278, №41. Р.39261-39264.Li X., O'Malley B.W. Unfolding the action of progesterone receptors // J. Biol. Chem. 2003. Vol.278, №41. Р.39261-39264.Maksay G., Laube B., Betz H. Subunit-specific modulation of glycine receptors by neurosteroids // Neuropharmacology. 2001. Vol.41, №3. Р.369-376.Maksay G., Laube B., Betz H. Subunit-specific modulation of glycine receptors by neurosteroids // Neuropharmacology. 2001. Vol.41, №3. Р.369-376.Meyer C., Schmid R., Scriba P.C., Wehling M. Purification and partial sequencing of high-affinity progesterone-binding site(s) from porcine liver membranes // Eur. J. Biochem. 1996. Vol.239, №3. Р.726-731.Meyer C., Schmid R., Scriba P.C., Wehling M. Purification and partial sequencing of high-affinity progesterone-binding site(s) from porcine liver membranes // Eur. J. Biochem. 1996. Vol.239, №3. Р.726-731.Mittelman-Smith M.A., Rudolph L.M., Mohr M.A., Micevych P.E. Rodent models of non-classical progesterone action regulating ovulation //Front. Endocrinol. (Lausanne). 2017. Vol.8. Р.165. doi: 10.3389/fendo.2017.00165Mittelman-Smith M.A., Rudolph L.M., Mohr M.A., Micevych P.E. Rodent models of non-classical progesterone action regulating ovulation //Front. Endocrinol. (Lausanne). 2017. Vol.8. Р.165. doi: 10.3389/fendo.2017.00165Mulac-Jericevic B., Conneely O.M. Reproductive tissue selective actions of progesterone receptors // Reproduction. 2004. Vol.128, №2. Р.139-146.Mulac-Jericevic B., Conneely O.M. Reproductive tissue selective actions of progesterone receptors // Reproduction. 2004. Vol.128, №2. Р.139-146.Obermann W.M., Sondermann H., Russo A.A., Pavletich N.P., Hartl F.U. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis // J. Cell Biol. 1998. Vol.143, №4. Р.901-910.Obermann W.M., Sondermann H., Russo A.A., Pavletich N.P., Hartl F.U. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis // J. Cell Biol. 1998. Vol.143, №4. Р.901-910.Oehler M.K., Rees M.C., Bicknell R. Steroids and the endometrium // Curr. Med. Chem. 2000. Vol.7, №5. Р.543-560.Oehler M.K., Rees M.C., Bicknell R. Steroids and the endometrium // Curr. Med. Chem. 2000. Vol.7, №5. Р.543-560.Ohta H., Kimura I., Konishi M., Itoh N. Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis // Front. Mol. Biosci. 2015. Vol.2. Р.24. doi: 10.3389/fmolb.2015.00024Ohta H., Kimura I., Konishi M., Itoh N. Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis // Front. Mol. Biosci. 2015. Vol.2. Р.24. doi: 10.3389/fmolb.2015.00024Papamitsou T., Chatzistamatiou M., Grammatikopoulou D., Papadopoulou K., Lakis S., Economou Z., Papadopoulou C., Sioga A. Low expression of progesterone receptor A in intermediate trophoblast of miscarriages // Histol. Histopathol. 2011. Vol.26, №5. Р. 609-614. doi: 10.14670/HH-26.609Papamitsou T., Chatzistamatiou M., Grammatikopoulou D., Papadopoulou K., Lakis S., Economou Z., Papadopoulou C., Sioga A. Low expression of progesterone receptor A in intermediate trophoblast of miscarriages // Histol. Histopathol. 2011. Vol.26, №5. Р. 609-614. doi: 10.14670/HH-26.609Park M.N., Park K.H., Lee J.E., Shin Y.Y., An S.M., Kang S.S., Cho W.S., An B.S., Kim S.C. The expression and activation of sex steroid receptors in the preeclamptic placenta // Int. J. Mol. Med. 2018. Vol.41, №5. Р.2943-2951. doi: 10.3892/ijmm.2018.3474Park M.N., Park K.H., Lee J.E., Shin Y.Y., An S.M., Kang S.S., Cho W.S., An B.S., Kim S.C. The expression and activation of sex steroid receptors in the preeclamptic placenta // Int. J. Mol. Med. 2018. Vol.41, №5. Р.2943-2951. doi: 10.3892/ijmm.2018.3474Peluso J.J., Pru J.K. Non-canonical progesterone signaling in granulosa cell function // Reproduction. 2014. Vol.147, №5. Р. R169-178. doi: 10.1530/REP-13-0582Peluso J.J., Pru J.K. Non-canonical progesterone signaling in granulosa cell function // Reproduction. 2014. Vol.147, №5. Р. R169-178. doi: 10.1530/REP-13-0582Peluso J.J., Yuan A., Liu X., Lodde V. Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells // Biol. Reprod. 2013. Vol.88, №1. Р.20. doi: 10.1095/biolreprod.112.10303Peluso J.J., Yuan A., Liu X., Lodde V. Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells // Biol. Reprod. 2013. Vol.88, №1. Р.20. doi: 10.1095/biolreprod.112.10303Pratt W.B., Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery // Exp. Biol. Med. (Maywood). 2003. Vol.228, №2. Р.111-133Pratt W.B., Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery // Exp. Biol. Med. (Maywood). 2003. Vol.228, №2. Р.111-133Rajaram R.D., Brisken C. Paracrine signaling by progesterone // Mol. Cell. Endocrinol. 2012. Vol.357, №1-2. Р.80-90. doi: 10.1016/j.mce.2011.09.018Rajaram R.D., Brisken C. Paracrine signaling by progesterone // Mol. Cell. Endocrinol. 2012. Vol.357, №1-2. Р.80-90. doi: 10.1016/j.mce.2011.09.018Rousseaux C.G., Greene S.F. Sigma receptors [σRs]: biology in normal and diseased states // J. Recept. Signal. Transduct. Res. 2016. Vol.36, №4. Р.327-388. doi: 10.3109/10799893.2015.1015737Rousseaux C.G., Greene S.F. Sigma receptors [σRs]: biology in normal and diseased states // J. Recept. Signal. Transduct. Res. 2016. Vol.36, №4. Р.327-388. doi: 10.3109/10799893.2015.1015737Ryu C.S., Klein K., Zanger U.M. Membrane associated progesterone receptors: promiscuous proteins with pleiotropic functions - focus on interactions with cytochromes P450 // Front. Pharmacol. 2017. Vol.8. Р.159. doi: 10.3389/fphar.2017.00159Ryu C.S., Klein K., Zanger U.M. Membrane associated progesterone receptors: promiscuous proteins with pleiotropic functions - focus on interactions with cytochromes P450 // Front. Pharmacol. 2017. Vol.8. Р.159. doi: 10.3389/fphar.2017.00159Schumacher M., Guennoun R., Stein D.G., De Nicola A/F. Progesterone: therapeutic opportunities for neuroprotection and myelin repair // Pharmacol. Ther. 2007. Vol.116, №1. Р.77-106.Schumacher M., Guennoun R., Stein D.G., De Nicola A/F. Progesterone: therapeutic opportunities for neuroprotection and myelin repair // Pharmacol. Ther. 2007. Vol.116, №1. Р.77-106.Soloff M.S., Jeng Y.J., Izban M.G., Sinha M., Luxon B.A., Stamnes S.J., England S.K. Effects of progesterone treatment on expression of genes involved in uterine quiescence // Reprod. Sci. 2011. Vol.18, №8. Р.781-797. doi: 10.1177/1933719111398150Soloff M.S., Jeng Y.J., Izban M.G., Sinha M., Luxon B.A., Stamnes S.J., England S.K. Effects of progesterone treatment on expression of genes involved in uterine quiescence // Reprod. Sci. 2011. Vol.18, №8. Р.781-797. doi: 10.1177/1933719111398150Thomas P. Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions // Front. Neuroendocrinol. 2008. Vol.29, №2. Р.292-312. doi: 10.1016/j.yfrne.2008.01.001Thomas P. Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions // Front. Neuroendocrinol. 2008. Vol.29, №2. Р.292-312. doi: 10.1016/j.yfrne.2008.01.001Tokumoto T., Hossain M.B., Wang J. Establishment of procedures for studying mPR-interacting agents and physiological roles of mPR // Steroids. 2016. Vol.111. Р.79-83. doi: 10.1016/j.steroids.2016.02.015Tokumoto T., Hossain M.B., Wang J. Establishment of procedures for studying mPR-interacting agents and physiological roles of mPR // Steroids. 2016. Vol.111. Р.79-83. doi: 10.1016/j.steroids.2016.02.015Wei L.L., Hawkins P., Baker C., Norris B., Sheridan P.L., Quinn P.G. An aminoterminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity // Mol. Endocrinol. 1996. Vol.10, №11. Р.1379-1387.Wei L.L., Hawkins P., Baker C., Norris B., Sheridan P.L., Quinn P.G. An aminoterminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity // Mol. Endocrinol. 1996. Vol.10, №11. Р.1379-1387.Wu W.X., Derks J.B., Zhang Q., Nathanielsz P.W. Changes in heat shock protein - 90 and -70 messenger ribonucleic acid in uterine tissues of the ewe in relation to parturition and regulation by estradiol and progesterone // Endocrinology. 1996. Vol.137. Р.5685-5693.Wu W.X., Derks J.B., Zhang Q., Nathanielsz P.W. Changes in heat shock protein - 90 and -70 messenger ribonucleic acid in uterine tissues of the ewe in relation to parturition and regulation by estradiol and progesterone // Endocrinology. 1996. Vol.137. Р.5685-5693.Zachariades E., Mparmpakas D., Pang Y., Rand-Weaver M., Thomas P., Karteris E. Changes in placental progesterone receptors in term and preterm labour // Placenta. 2012. Vol.33, №5. Р.367-372. doi:10.1016/j.placenta.2012.01.002Zachariades E., Mparmpakas D., Pang Y., Rand-Weaver M., Thomas P., Karteris E. Changes in placental progesterone receptors in term and preterm labour // Placenta. 2012. Vol.33, №5. Р.367-372. doi:10.1016/j.placenta.2012.01.002Zhu Y., Bond J., Thomas P. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor // Proc. Natl Acad. Sci. USA. 2003. Vol.100, №5. Р.2237-2242.Zhu Y., Bond J., Thomas P. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor // Proc. Natl Acad. Sci. USA. 2003. Vol.100, №5. Р.2237-2242.Zhu Y., Rice C.D., Pang Y., Pace M., Thomas P. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes // Proc. Natl Acad. Sci. USA. 2003. Vol.100, №5. Р.2231-2236.Zhu Y., Rice C.D., Pang Y., Pace M., Thomas P. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes // Proc. Natl Acad. Sci. USA. 2003. Vol.100, №5. Р.2231-2236.

The authors declare that there are no conflicts of interest present.