cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.12737/article_5c127a27ba9a85.88292840cfpd-164Research ArticleСтатьиРОЛЬ МЕЗЕНХИМАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК В ЛЕЧЕНИИ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ (ОБЗОР ЛИТЕРАТУРЫ)ROLE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REVIEW)ЦелуйкоС. С.TseluykoS. S.noemail@neicon.ruЯценкоА. А.YatsenkoA. A.noemail@neicon.ruЛеоновД. В.LeonovD. V.noemail@neicon.ruУстиновЕ. М.UstinovE. M.noemail@neicon.ruКушнаревВ. А.KushnarevV. A.noemail@neicon.ruАмурская государственная медицинская академияAmur State Medical AcademyООО «Некст Ген Биосистем»Medical Research Center “Next Gen Biosystem"201818112019070121128Copyright © Целуйко С.С., Яценко А.А., Леонов Д.В., Устинов Е.М., Кушнарев В.А., 20192019Целуйко С.С., Яценко А.А., Леонов Д.В., Устинов Е.М., Кушнарев В.А.Tseluyko S.S., Yatsenko A.A., Leonov D.V., Ustinov E.M., Kushnarev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/164

Существующие методы лечения больных хронической обструктивной болезнью легких недостаточно эффективны и ведут к прогрессированию заболевания с последующей инвалидизацией больного. На сегодняшний день одним из перспективных методов терапии пациентов с хронической обструктивной болезнью легких является использование подходов регенеративной медицины, в частности, мезенхимальных стволовых клеток. В обзоре рассмотрены достижения научных групп, разрабатывающих подходы к терапии больных хронической обструктивной болезнью легких на основе применения мезенхимальных стволовых клеток, акцентировано внимание на проблемах патогенеза и возможных способах объяснения механизма действия мезенхимальных стволовых клеток, освещены вопросы безопасности применения мезенхимальных стволовых клеток.

Current methods of treatment of chronic obstructive pulmonary disease are not effective enough and lead to the progression of the disease and disability of the patient. One of the promising methods of chronic obstructive pulmonary disease therapy is the use of the possibilities of regenerative medicine, in particular, mesenchymal stem cells. The review demonstrates the achievements of research groups developing approaches to chronic obstructive pulmonary disease therapy based on mesenchymal stem cells. Our attention was focused on the problems and possible ways to show the mechanism of action of mesenchymal stem cells. The issues of safety of mesenchymal stem cells application are also discussed.

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The authors declare that there are no conflicts of interest present.