cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.12737/artide_5d0ad2e5d54867.15780111cfpd-217Research ArticleОБЗОРЫREVIEWSРецепторы эстрогенов (обзор литературы). Часть 1Estrogen receptors (review). Part 1ДовжиковаИ. В.DovzhikovaI. V.

Инна Викторовна Довжикова - доктор биологических наук, ведущий научный сотрудник лаборатории механизмов этиопатогенеза и восстановительных процессов дыхательной системы при неспецифических заболеваниях легких.

675000, Благовещенск, ул. Калинина, 22

Inna V. Dovzhikova - PhD, DSc, Leading staff scientist of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases.

22 Kalinina Str., Blagoveshchensk, 675000

dov_kova100@rambler.ruАндриевскаяИ. А.AndrievskayaI. A.

675000, Благовещенск, ул. Калинина, 22

22 Kalinina Str., Blagoveshchensk, 675000

Федеральное государственное бюджетное научное учреждение Дальневосточный научный центр физиологии и патологии дыханияFar Eastern Scientific Center of Physiology and Pathology of Respiration201924112019072120127Copyright © Довжикова И.В., Андриевская И.А., 20192019Довжикова И.В., Андриевская И.А.Dovzhikova I.V., Andrievskaya I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/217

Статья представляет собой обзор литературы, состоящий из двух частей, в котором сконцентрированы современные данные о рецепторах важнейших в период беременности гормонов - эстрогенов. В первой части сообщения описаны виды рецепторов эстрогенов, показаны особенности их структуры. Рассмотрены геномные и негеномные механизмы действия гормона, осуществляющиеся через разные виды рецепторов: ядерных и мембранно-связанных. Кратко охарактеризованы внутриклеточные сигнальные пути, стимулированные эстрогенами. Подчеркнуто первостепенное значение точной и динамической регуляции активности гормонов. Сделан вывод о необходимости дальнейшего исследования рецепторов. Вторая часть обзора литературы посвящается роли рецепторов эстрогенов во время беременности.

The article is a two-part review of the literature in which modern data on the receptors of the most important hormones during pregnancy, estrogens, are analyzed. The first part of the review describes the types of estrogen receptors and shows the features of their structure. Genomic and non-genomic mechanisms of hormone action are considered, which are realized through different types of receptors: nuclear and membrane-associated. There are also briefly characterized intracellular signaling pathways stimulated by estrogens. The paramount importance of accurate and dynamic regulation of the activity of hormones is emphasized. It was concluded that there is a necessity for further research of the estrogen receptors. The second part of the literature review focuses on the role of estrogen receptors during pregnancy.

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The authors declare that there are no conflicts of interest present.