cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2019-73-112-124cfpd-234Research ArticleОБЗОРЫREVIEWSРегуляция тиол-дисульфидными антиоксидантными системами окислительного стресса, индуцированного атмосферными взвешенными частицамиRegulation by thiol disulfide and antioxidant systems of oxidative stress induced by atmospheric suspended particlesБарсковаЛ. С.BarskovaL. S.

Людмила Сергеевна Барскова - аспирант, младший научный сотрудник, лаборатория медицинской экологии и рекреационных ресурсов.

690105, Владивосток, ул. Русская, 73 г

Lyudmila S. Barskova - Junior Staff Scientist, Laboratory of Medical Ecology and Recreational Resources.

73g Russkaya Str., Vladivostok, 690105

pretty_people_2016@mail.ruВиткинаТ. И.VitkinaT. I.

Татьяна Исааковна Виткина - доктор биологических наук, профессор РАН, заведующий лабораторией медицинской экологии и рекреационных ресурсов.

690105, Владивосток, ул. Русская, 73 г

Tatyana I. Vitkina - PhD, D.Sc. (Biol.), Professor RAS, Head of Laboratory of Medical Ecology and Recreational Resources.

73g Russkaya Str., Vladivostok, 690105

tash30@mail.ruВладивостокский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» - Научно-исследовательский институт медицинской климатологии и восстановительного леченияVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment201925112019073112124Copyright © Барскова Л.С., Виткина Т.И., 20192019Барскова Л.С., Виткина Т.И.Barskova L.S., Vitkina T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/234

В обзоре литературы показана роль тиоредоксиновой и глутатионовой антиоксидантных систем в защите организма от действия окислительного стресса, вызываемого воздействием микроразмерных твердых взвешенных частиц атмосферного воздуха. Дана характеристика свойств компонентов и параметров твердых взвешенных частиц, обусловливающих их окислительные способности. Основное внимание уделяется внутриклеточным и молекулярным механизмам, влияющим на многие антиокислительные реакции. Рассмотрены вопросы регуляции, модуляции и поддержания клеточного окислительно-восстановительного гомеостаза основными восстановительными тиолами.

The review is devoted to the role of thioredoxin and glutathione antioxidant systems in protection of the body against oxidative stress caused by exposure to micro-sized solid suspended particles of atmospheric air. The features of components and parameters of solid suspended particles determining their oxidative properties have been described. The focus is on intracellular and molecular mechanisms affecting many antioxidant reactions. The issues of regulation, modulation and maintenance of cellular redox homeostasis by key reducing thiols have been considered.

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The authors declare that there are no conflicts of interest present.