References

cfpd

Бюллетень физиологии и патологии дыхания

Bulletin Physiology and Pathology of Respiration

1998-5029

Дальневосточный научный центр физиологии и патологии дыхания

cfpd-602

Research Article

Статьи

ТРАНСПОРТ ЖИРНЫХ КИСЛОТ ЧЕРЕЗ МЕМБРАНУ (ОБЗОР ЛИТЕРАТУРЫ)

MEMBRANE FATTY ACIDS TRANSPORT (REVIEW)

Довжикова

Инна Викторовна

Dovzhikova

Inna V.

dncfpd@ramn.ru

Луценко

Михаил Тимофеевич

Lutsenko

Mikhail T.

Lucenkomt@mail.ru

Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМНFar Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS

2013

19022020

050130138

2020

Довжикова И.В., Луценко М.Т.

Dovzhikova I.V., Lutsenko M.T.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://cfpd.elpub.ru/jour/article/view/602

Докозагексаеновая и арахидоновая кислоты чрезвычайно важны для нормального развития плода во время беременности. Поскольку они не могут быть синтезированы плодом и плацентой, то обеспечение ими происходит путем транспорта через плаценту из материнской крови. В обзоре литературы рассмотрен механизм поступления длинноцепочечных жирных кислот, происходящий по двум путям: пассивная диффузия через мембрану и транспорт с помощью специальных белков. К последним относятся FABPpm/GOT2, FABP, FATP, кавеолин-1 и FAT/CD36. Большой раздел статьи посвящен особенностям поставки жирных кислот при беременности. Он включает в себя три этапа: диссоциация с белковым комплексом, транспорт через плазматическую мембрану и связывание их с внутриклеточными белками. Важную роль в избирательности поступления докозагексаеновой и арахидоновой кислот играют: pFABPpm, локализованный на плазматической мембране материнской стороны плаценты, FATP-1 и FATP-4. FABP направляют жирные кислоты в различные точки внутри синцитиотрофобласта или в плазму пуповины. Сделан вывод, что поступление длинноцепочечных жирных кислот к плоду является результатом комбинированных процессов, протекающих у матери и в фетоплацентарном комплексе.

Docosahexaenoic and arachidonic acids are extremely important for the normal fetus growth during pregnancy. As they cannot be synthesized by a fetus and placenta, the fetus gets them from mother’s blood through placenta transportation. The literature review deals with the mechanism of long-chained fatty acids transportation mechanism which occurs in two ways: passive diffusion through the membrane and transportation with the special proteins. The latter are presented by FABPpm/GOT2, FABP, FATP, caveolin-1 and FAT/CD36. A big part of the article is devoted to the features of fatty acids transportation at pregnancy. It includes three stages: dissociation with the protein complex, transportation through plasmatic membrane and their binding with intracellular proteins. pFABPpm localized on the plasmatic membrane of the maternal side of placenta, FATP-1 and FATP-4 play an important role in the selective transportation of docosahexaenoic and arachidonic acids. FABP directs fatty acids into different points inside syncytiotrophoblast or into umbilical cord plasma. The conclusion was made about the fact that the transportation of long-chained fatty acids to the fetus is the result of a number of processes which occur in a mother and in a fetoplacental complex.

жирные кислотытранспортные белкиплацентаfatty acidtransport proteinsplacenta

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The authors declare that there are no conflicts of interest present.