cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыханияcfpd-755Research ArticleСтатьиИНТЕРЛЕЙКИН 15 И ЕГО РОЛЬ В ИММУННОМ ВОСПАЛЕНИИINTERLEUKIN 15 AND ITS ROLE IN IMMUNE INFLAMMATIONСобкоЕлена АльбертовнаSobkoElena A.vbl2@krasgmu.ruСоловьеваИрина АнатольевнаSolovʹevaIrina A.solovieva.irina@inbox.ruДемкоИрина ВладимировнаDemkoIrina V.demko64@mail.ruКрапошинаАнгелина ЮрьевнаKraposhinaAngelina Yu.angelina-maria@inbox.ruГордееваНаталия ВладимировнаGordeevaNatalia V.natagorday@yandex.ruЧубароваСветлана ВладимировнаChubarovaSvetlana V.vbl2@krasgmu.ruИщенкоОльга ПетровнаIshenkoOl'ga P.fridag@yandex.ruЕгоровСтепан АлександровичEgorovStepan A.vbl2@krasgmu.ruБазароваАйсулуу СултанбаевнаBazarovaAysuluu S.rector@krasgmu.ruВтюринаСветлана СергеевнаVturinaSvetlana S.vbl2@krasgmu.ruКрасноярский государственный медицинский университет; Красноярская краевая клиническая больницаKrasnoyarsk State Medical University; Krasnoyarsk Regional Clinical HospitalКрасноярский государственный медицинский университетKrasnoyarsk State Medical University201520022020057113119Copyright © Собко Е.А., Соловьева И.А., Демко И.В., Крапошина А.Ю., Гордеева Н.В., Чубарова С.В., Ищенко О.П., Егоров С.А., Базарова А.С., Втюрина С.С., 20202020Собко Е.А., Соловьева И.А., Демко И.В., Крапошина А.Ю., Гордеева Н.В., Чубарова С.В., Ищенко О.П., Егоров С.А., Базарова А.С., Втюрина С.С.Sobko E.A., Solovʹeva I.A., Demko I.V., Kraposhina A.Y., Gordeeva N.V., Chubarova S.V., Ishenko O.P., Egorov S.A., Bazarova A.S., Vturina S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/755

С момента клонирования интерлейкина-15 проведено немало клинических исследований, посвященных изучению молекулярной и клеточной структуры данного цитокина. Важной особенностью интерлейкина-15 является его структурное и функциональное сходство с интерлейкином-2, однако специфичность интерлейкина-15 обеспечивается уникальной собственной α-цепи рецептора. В обзоре приведены современные данные о молекулярном строении, механизме действия и биологических эффектах интерлейкина-15, роли данного цитокина в развитии заболеваний и его потенциальной клинической значимости в качестве терапевтического агента.

Since the cloning of interleukin-15, a number of clinical studies on molecular structure of this cytokine has been done. An important feature of interleukin-15 is its structural and functional similarity with interleukin-2, but the specificity of interleukin-15 is provided with its own unique receptor α-chain. The review presents recent data on the molecular structure, mechanism of action and biological effects of interleukin-15, the role of this cytokine in the development of the disease and its potential clinical significance as a therapeutic agent.

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The authors declare that there are no conflicts of interest present.