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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cfpd</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень физиологии и патологии дыхания</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin Physiology and Pathology of Respiration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5029</issn><publisher><publisher-name>Дальневосточный научный центр физиологии и патологии дыхания</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36604/1998-5029-2020-77-99-106</article-id><article-id custom-type="elpub" pub-id-type="custom">cfpd-825</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Клинико-диагностические особенности легкой бронхиальной астмы</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and diagnostic features of mild asthma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьева</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Leontieva</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нигора Минавваровна Леонтьева, аспирант, младший научный сотрудник кафедры внутренних болезней и иммунологии с курсом постдипломного образования</p><p>660022, г. Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Nigora M. Leontieva, MD, Postgraduate Student of Department of Internal Medicine and Immunology with Postgraduate Education Course</p><p>Doctor of Functional Diagnosis</p></bio><email xlink:type="simple">nigora-razzakova@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demko</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Владимировна Демко, д-р мед. наук, профессор, зав. кафедрой внутренних болезней и иммунологии с курсом постдипломного образования</p><p>зав. легочно-аллергологическим центром </p></bio><bio xml:lang="en"><p>Irina V. Demko, MD, PhD, D.Sc. (Med.), Professor, Head of Department of Internal Medicine and Immunology with Postgraduate Education Course</p><p>Head of Pulmonary Allergology Сenter</p></bio><email xlink:type="simple">vbl2@krasgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Собко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sobko</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Альбертовна Собко, д-р мед. наук, профессор кафедры внутренних болезней и иммунологии с курсом постдипломного образования</p><p>заведующая отделением аллергологии </p></bio><bio xml:lang="en"><p>Elena A.Sobko, MD, PhD, D.Sc. (Med.), Professor of Department of Internal Medicine and Immunology with Postgraduate Education Course</p><p>Head of Department of Allergology</p></bio><email xlink:type="simple">vbl2@krasgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ищенко</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ischenko</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Петровна Ищенко, канд. мед. наук, доцент кафедры внутренних болезней и иммунологии с курсом постдипломного образования</p><p>врач аллерголог </p></bio><bio xml:lang="en"><p>Olga P. Ischenko, MD, PhD (Med.), Associate Professor of Department of Internal Medicine and Immunology with Postgraduate Education Course</p><p>Allergologist </p></bio><email xlink:type="simple">vbl2@krasgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф.Войно-Ясенецкого» Министерства здравоохранения Российской Федерации; &#13;
Краевое государственное бюджетное учреждение здравоохранения «Краевая клиническая больница»</institution></aff><aff xml:lang="en"><institution>Krasnoyarsk State Medical University; &#13;
Krasnoyarsk Regional Clinical Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2020</year></pub-date><volume>0</volume><issue>77</issue><fpage>99</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Леонтьева Н.М., Демко И.В., Собко Е.А., Ищенко О.П., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Леонтьева Н.М., Демко И.В., Собко Е.А., Ищенко О.П.</copyright-holder><copyright-holder xml:lang="en">Leontieva N.M., Demko I.V., Sobko E.A., Ischenko O.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cfpd.elpub.ru/jour/article/view/825">https://cfpd.elpub.ru/jour/article/view/825</self-uri><abstract><p>На сегодняшний день в мире наблюдается высокая распространенность бронхиальной астмы (БА), а легкое течение болезни занимает лидирующие позиции в структуре заболеваемости. Легкая форма астмы является патологией, которая при длительном бессимптомном течении может привести к тяжелым обострениям, и даже к летальному исходу. Несмотря на это, в настоящее время присутствуют сложности, приводящие к недостаточной и несвоевременной диагностике БА, вследствие чего у пациентов с легким течением заболевания часто регистрируются обострения. В литературном обзоре рассмотрены клинические особенности БА легкого течения, а так же современные принципы терапии пациентов с легкой степенью тяжести заболевания. Кроме того в работе представлен обзор последних исследований, направленных на изучение морфофункциональных и патофизиологических изменений при БА легкого течения. Легкая астма, как правило, стабильна, но иногда может спонтанно перерастать в крайне тяжелую, и причины таких изменений остаются до конца не определенными. Анализ проведенных исследований позволил выявить эндогенные и экзогенные факторы, влияющие на индукцию БА и усугубляющие её течение. Важным является и то, что бронхиальная обструкция, по-видимому, проявляется с первых лет жизни и сохраняется в последующем, в связи с чем важно понимать ценность диагностических мероприятий и эффективность вмешательств на ранних сроках развития бронхиальной обструкции для предотвращения прогрессирования заболевания. В связи с этим проблемы ранней диагностики БА легкого течения и своевременного назначения соответствующей терапии остаются на сегодняшний день важными и актуальными.</p></abstract><trans-abstract xml:lang="en"><p>Today in the world there is a high prevalence of asthma, and the mild severity occupies a leading position in the structure of morbidity. A mild asthma is a pathology that, with a prolonged asymptomatic course, can lead to severe exacerbations, and even death. Despite this, at present there are difficulties leading to an insufficient and untimely diagnosis of asthma, as a result of which exacerbations are often recorded in patients with a mild severity of the disease. The literature review examined the clinical features of mild asthma, as well as the modern principles of treatment of patients with mild disease severity. In addition, a review of recent studies aimed at studying morphological and pathophysiological changes in mild asthma is presented. Mild asthma, as a rule, is stable, but sometimes it can spontaneously develop into extremely severe, and the causes of such changes remain unclear. The analysis of the studies revealed endogenous and exogenous factors that affect the induction of bronchial asthma and exacerbate its course. It is also important that bronchial obstruction, apparently, appears from the first years of life and persists in the future, in connection with which it is important to understand the value of diagnosis measures and the effectiveness of interventions in the early stages of bronchial obstruction to prevent disease progression. In this regard, the problems of early diagnosis of mild asthma and the timely appointment of appropriate therapy remain today important and relevant.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>легкая бронхиальная астма</kwd><kwd>терапия легкой астмы</kwd><kwd>диагностика</kwd><kwd>обструкция дыхательных путей</kwd><kwd>респираторные симптомы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mild asthma</kwd><kwd>therapy of mild asthma</kwd><kwd>diagnosis</kwd><kwd>airway obstruction</kwd><kwd>respiratory symptoms</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Обзор литературы выполнен в рамках исследования, реализующегося при финансовой поддержке РФФИ (научный проект №19-315-90030).</funding-statement><funding-statement xml:lang="en">The literature review was carried out within the framework of reported study that funded by RFBR (project No 19-315-90030).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральные клинические рекомендации по диагностике и лечению бронхиальной астмы, 2019. 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