<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cfpd</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень физиологии и патологии дыхания</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin Physiology and Pathology of Respiration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-5029</issn><publisher><publisher-name>Дальневосточный научный центр физиологии и патологии дыхания</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36604/1998-5029-2020-78-84-91</article-id><article-id custom-type="elpub" pub-id-type="custom">cfpd-838</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Влияние комплексной медицинской реабилитации на функциональные показатели системы дыхания и качество жизни у больных, перенесших COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Influence of complex medical rehabilitation on pulmonary function and quality of life in patients after COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8396-1936</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крюков</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kryukov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евгений Владимирович Крюков, д-р мед. наук, профессор, член-корреспондент РАН, начальник;</p><p>105094, г. Москва, пл. Госпитальная, 3</p></bio><bio xml:lang="en"><p>Evgeniy V. Kryukov, MD, PhD, DSc, Professor, Corresponding Member of Russian Academy of Sciences, Commander</p><p>3 Gospitalʹnaya Sq., Moscow, 105094</p></bio><email xlink:type="simple">evgeniy.md@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7486-4990</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савушкина</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Savushkina</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Игоревна Савушкина, канд. биол. наук, зав. отделением исследований функции внешнего дыхания, Центр функционально-диагностических исследований; старший научный сотрудник лаборатории функциональных и ультразвуковых методов исследования </p><p>105094, г. Москва, пл. Госпитальная, 3;115682, г. Москва, Ореховый бульвар, 28</p></bio><bio xml:lang="en"><p>Olʹga I. Savushkina, MD, PhD (Biol.), Head of Department of Lung Function Testing, Center of Functional Diagnostic Investigations; Senior Staff Scientist of the Laboratory of Functional and Ultrasonic Research Methods</p><p>3 Gospitalʹnaya Sq., Moscow, 105094;28 Orekhovuy Boulevard, Moscow, 115682</p></bio><email xlink:type="simple">olga-savushkina@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малашенко</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Malashenko</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Михайловна Малашенко, канд. мед. наук, зав. отделением физиотерапии </p><p>105094, г. Москва, пл. Госпитальная, 3</p></bio><bio xml:lang="en"><p>Maria M. Malashenko, MD, PhD (Med.), Head of Department of Physiotherapy</p><p>3 Gospitalʹnaya Sq., Moscow, 105094</p></bio><email xlink:type="simple">mar-malashenko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2001-5504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черняк</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherniak</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Владимирович Черняк, канд. мед. наук, зав. лабораторией функциональных и ультразвуковых методов исследования</p><p>115682, г. Москва, Ореховый бульвар, 28</p></bio><bio xml:lang="en"><p>Alexander V. Cherniak, MD, PhD (Med.), Head of Laboratory of Functional and Ultrasonic Research Methods</p><p>28 Orekhovuy Boulevard, Moscow, 115682</p></bio><email xlink:type="simple">achi2000@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бобр</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bobr</surname><given-names>I. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Анатольевна Бобр, зав. кабинетом отделения физиотерапии</p><p>105094, г. Москва, пл. Госпитальная, 3</p></bio><bio xml:lang="en"><p>Irirna А.Bobr, MD, Head of the Office of Physiotherapy</p><p>3 Gospitalʹnaya Sq., Moscow, 105094</p></bio><email xlink:type="simple">irina.bobr@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмагилова</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Ismagilova</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Резеда Рифгатовна Исмагилова, зав. кабинетом отделения физиотерапии</p><p>105094, г. Москва, пл. Госпитальная, 3</p></bio><bio xml:lang="en"><p>Reseda Р. Ismagilova, MD, Head of the Office of Physiotherapy</p><p>3 Gospitalʹnaya Sq., Moscow, 105094</p></bio><email xlink:type="simple">rezeda.ismagilowa.1972@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Главный военный клинический госпиталь имени академика Н.Н.Бурденко» Министерства обороны Российской Федерации</institution></aff><aff xml:lang="en"><institution>Acad. N.N.Burdenko Main Military Clinical Hospital of Russian Federation Ministry of Defence</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Главный военный клинический госпиталь имени академика Н.Н.Бурденко» Министерства обороны Российской Федерации;&#13;
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентства России</institution></aff><aff xml:lang="en"><institution>Acad. N.N.Burdenko Main Military Clinical Hospital of Russian Federation Ministry of Defence;&#13;
Pulmonology Scientific Research Institute of Federal Medical and Biological Agency</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентства России</institution></aff><aff xml:lang="en"><institution>Pulmonology Scientific Research Institute of Federal Medical and Biological Agency</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2020</year></pub-date><volume>0</volume><issue>78</issue><fpage>84</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крюков Е.В., Савушкина О.И., Малашенко М.М., Черняк А.В., Бобр И.А., Исмагилова Р.Р., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Крюков Е.В., Савушкина О.И., Малашенко М.М., Черняк А.В., Бобр И.А., Исмагилова Р.Р.</copyright-holder><copyright-holder xml:lang="en">Kryukov E.V., Savushkina O.I., Malashenko M.M., Cherniak A.V., Bobr I.А., Ismagilova R.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cfpd.elpub.ru/jour/article/view/838">https://cfpd.elpub.ru/jour/article/view/838</self-uri><abstract/><trans-abstract xml:lang="en"><p>An important stage in the study of COVID-19 and its impact on quality of life is the study of lung function during the period of convalescence. Aim. To assess the influence of complex medical rehabilitation (MR) on pulmonary function, dyspnea, muscle weakness, quality of life, anxiety and depression in patients after COVID-19. Materials and methods. The study included 19 patients after COVID-19 (17 men and 2 woman, median age – 45 years), who were treated at the Main Military Clinical Hospital of the Ministry of Defense named after N.N.Burdenko. The second stage of complex MR included medical and physical therapy, and physiotherapy. Before and after the MR pulmonary function tests were performed, also the scores of mMRC, MRSweakness, HADS scales, the scores of EQ-5D Questionnaire were assessed. Results. Before the start of MR, on average, the severity of dyspnea in the group was mild, muscle strength was slightly reduced, the quality of life score was 80 points, anxiety and depression were not detected. The medians of all pulmonary function parameters were within normal values unless anomaly of the lung diffusion capacity in 14 (74%) cases. Repeated examination showed a statistically significant reduction in the degree of dyspnea, increased muscle strength, improved quality of life, increased VC, FVC, FEV1 , DLCO, with a median increase of 5% pred. or 230 mL, 5% pred. (260 mL), 6% pred. (210 mL) and 6% pred. (1,75 mL/min/mmHg), respectively. Conclusion. Our study demonstrated the importance and effectiveness of complex rehabilitation after COVID-19.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>функция системы дыхания</kwd><kwd>диффузионная способность легких</kwd><kwd>медицинская реабилитация</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pulmonary function</kwd><kwd>lung diffusion capacity</kwd><kwd>medical rehabilitation</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)» версия 9 от 26.10.2020. URL: https://minzdrav.gov.ru/ministry/med_covid19.</mixed-citation><mixed-citation xml:lang="en">Interim Guidelines "Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)" version 9 (October 26, 2020) (in Russian). Available at: https://minzdrav.gov.ru/ministry/med_covid19</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Mo X., Jian W., Su Z., Chen M., Peng H., Peng P., Lei Ch., Chen R., Zhong N., Li S. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge // Eur. Respir. J. 2020. Vol.55, №6. Article number: 2001217. doi.10.1183/13993003.01217-2020</mixed-citation><mixed-citation xml:lang="en">Mo X., Jian W., Su Z., Chen M., Peng H., Peng P., Lei Ch., Chen R., Zhong N., Li S. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur. Respir. J. 2020; 55(6):2001217. doi.10.1183/13993003.01217-2020</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Y., Tan C., Wu J., Chen M., Wang Z., Luo L., Zhou X., Liu X., Huang X., Yuan S., Chen Ch., Gao F., Huang J., Shan H., Liu J. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase // Respir. Res. 2020. Vol.21, №1. Article number: 163. doi:10.1186/s12931-020-01429-6</mixed-citation><mixed-citation xml:lang="en">Huang Y., Tan C., Wu J., Chen M., Wang Z., Luo L., Zhou X., Liu X., Huang X., Yuan S., Chen Ch., Gao F., Huang J., Shan H., Liu J. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respir. Res. 2020; 21(1):163. doi:10.1186/s12931-020-01429-6</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А.А., Савушкина О.И., Черняк А.В., Кулагина И.Ц., Крюков Е.В. Клинико-функциональная характеристика пациентов, перенесших новую коронавирусную инфекцию COVID-19 // Практическая пульмонология. 2020. №1. С.78–81.</mixed-citation><mixed-citation xml:lang="en">Zaitsev A.A., Savushkina O.I., Chernyak A.V., Kulagina I.C., Kryukov E.V. Clinical and Functional Characteristics of Patients Who Recovered from the Novel Coronavirus Infection (COVID-19). Prakticheskaya pul'monologiya 2020 (1):78–81 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Савушкина О.И., Черняк А.В., Крюков Е.В., Кулагина И.Ц., Самсонова М.В., Калманова Е.Н., Зыков К.А. Функциональные нарушения системы дыхания в период раннего выздоровления после COVID-19 // Медицинский алфавит. 2020. №25. C.7–12. https://doi.org/10.33667/2078-5631-2020-25-7-12</mixed-citation><mixed-citation xml:lang="en">Savushkina O.I., Cherniak A.V., Kryukov E.V., Kulagina I.T., Samsonova M.V., Kalmanova E.N., Zykov K.A. Pulmonary function after COVID-19 in early convalescence phase. Medical alphabet 2020; (25):7–12 (in Russian). https://doi.org/10.33667/2078-5631-2020-25-7-12</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Frija-Masson J., Debray M.-P., Gilbert M., Lescure F.-X., Travert F., Borie R., Khalil F., Crestani B., d'Ortho M.-P., Bancal C. Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection // Eur. Respir. J. 2020. Vol.56, №2. Article number: 2001754. doi: 10.1183/13993003.01754-2020</mixed-citation><mixed-citation xml:lang="en">Frija-Masson J., Debray M.-P., Gilbert M., Lescure F.-X., Travert F., Borie R., Khalil F., Crestani B., d'Ortho M.-P., Bancal C. Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection. Eur. Respir. J. 2020; 56(2):2001754. doi: 10.1183/13993003.01754-2020</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Временные методические рекомендации «Медицинская реабилитация при новой коронавирусной инфекции COVID-19» версия 2 от 31.07.2020. URL: https://www.edu.rosminzdrav.ru/fileadmin/user_upload/specialists/COVID19/dop-materials/VMR_medreabilitacija_COVID_versija2.pdf.</mixed-citation><mixed-citation xml:lang="en">Interim Guidelines "Medical rehabilitation in the new COVID-coronavirus infection 19" Version 2 (July 31, 2020) (in Russian). Available at: https://www.edu.rosminzdrav.ru/fileadmin/user_upload/specialists/COVID-19/dop-materials/VMR_medreabilitacija_COVID_versija2.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Мещерякова Н.Н., Белевский А.С., Кулешов А.В. Легочная реабилитация пациентов, перенесших коронавирусную инфекцию COVID-19 (клинические примеры) // Пульмонология. 2020. Т.30, №5. С.715–722. https://doi.org/10.18093/0869-0189-2020-30-5-715-722</mixed-citation><mixed-citation xml:lang="en">Meshcheryakova N.N., Belevskiy A.S., Kuleshov A.V. Pulmonary rehabilitation of patients with coronavirus infection COVID-19, clinical examples. Pulmonologiya 2020; 30(5):715–722 (in Russian). https://doi.org/10.18093/0869-0189-2020-30-5-715-722</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г., Айсанов З.Р., Чикина С.Ю. Черняк А.В., Калманова Е.Н. Федеральные клинические рекомендации Российского респираторного общества по использованию метода спирометрии // Пульмонология. 2014. №6. С.11–23. https://doi.org/10.18093/0869-0189-2014-0-6-11-24</mixed-citation><mixed-citation xml:lang="en">Chuchalin A.G., Aysanov Z.R., Chikina S.Yu., Chernyak A.V., Kalmanova E.N. Federal guidelines of Russian Respiratory Society on spirometry. Pulmonologiya 2014; (6):11–23 (in Russian). https://doi.org/10.18093/0869-0189-2014-0-6-11-24</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Graham B.L., Steenbruggen I., Miller M.R., Burgos F., Casaburi R., Coates A., Crapo R., Enright P., van der Grinten C.P., Gustafsson P., Jensen R., Johnson D.C., MacIntyre N., McKay R., Navajas D., Pedersen O.F., Pellegrino R., Viegi G., Wanger J.; ATS/ERS Task Force. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement // Am. J. Respir. Crit. Care Med. 2019. Vol.200, №8. P. P.70–88. doi: 10.1164/rccm.201908-1590ST</mixed-citation><mixed-citation xml:lang="en">Graham B.L., Steenbruggen I., Miller M.R., Burgos F., Casaburi R., Coates A., Crapo R., Enright P., van der Grinten C.P., Gustafsson P., Jensen R., Johnson D.C., MacIntyre N., McKay R., Navajas D., Pedersen O.F., Pellegrino R., Viegi G., Wanger J.; ATS/ERS Task Force. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. Am. J. Respir. Crit. Care Med. 2019; 200(8):e70–e88. doi: 10.1164/rccm.201908-1590ST</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wanger J., Clausen J.L., Coates A., Pedersen O.F., Brusasco V., Burgos F., Casaburi R., Crapo R., Enright P., van der Grinten C.P., Gustafsson P., Hankinson J., Jensen R., Johnson D., Macintyre N., McKay R., Miller M.R., Navajas D., Pellegrino R., Viegi G. Standardisation of the measurement of lung volumes // Eur. Respir. J. 2005. Vol.26, №3. Р.511– 522. doi: 10.1183/09031936.05.00035005</mixed-citation><mixed-citation xml:lang="en">Wanger J., Clausen J.L., Coates A., Pedersen O.F., Brusasco V., Burgos F., Casaburi R., Crapo R., Enright P., van der Grinten C.P., Gustafsson P., Hankinson J., Jensen R., Johnson D., Macintyre N., McKay R., Miller M.R., Navajas D., Pellegrino R., Viegi G. Standardisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26(3):511–522. doi: 10.1183/09031936.05.00035005</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Graham B.L., Brusasco V., Burgos F., Cooper B.G., Jensen R., Kendrick A., MacIntyre N.R., Thompson B.R., Wanger J. 2017 ERS/ATS Standards for single-breath carbon monoxide uptake in the lung // Eur. Respir. J. 2017. Vol.49, №1. Article number: 1600016. doi: 10.1183/13993003.00016-2016</mixed-citation><mixed-citation xml:lang="en">Graham B.L., Brusasco V., Burgos F., Cooper B.G., Jensen R., Kendrick A., MacIntyre N.R., Thompson B.R., Wanger J. 2017 ERS/ATS Standards for single-breath carbon monoxide uptake in the lung. Eur. Respir. J. 2017; 49(1):1600016. doi: 10.1183/13993003.00016-2016</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Рекомендации Российского респираторного общества по проведению функциональных исследований системы дыхания в период пандемии COVID-19 Версия 1.1. от 19.05.2020. URL: https://spulmo.ru/upload/rekomendacii_rro_fvd_COVID_19_rev1_1_01062020.pdf</mixed-citation><mixed-citation xml:lang="en">Russian Respiratory Society recommendations for the respiratory system functional studies during a pandemic COVID-19 Version 1.1. (May 19, 2020) (in Russian). Available at: https://spulmo.ru/upload/rekomendacii_rro_fvd_COVID_19_rev1_1_01062020.pdf</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., Yernault J.C. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society // Eur. Respir. J. 1993. Vol.6 (Suppl.16). P.5–40.</mixed-citation><mixed-citation xml:lang="en">Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., Yernault J.C. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur. Respir. J. 1993; 6(Suppl.16):5–40.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Guan W., Ni Z., Hu Yu, Liang W., Ou C., He J., Liu L., Shan H., Lei C., Hui D.S.C., Du B., Li L., Zeng G., Yuen K.-Y., Chen R., Tang C., Wang T., Chen P., Xiang J., Li S., Wang Jin-lin, Liang Z., Peng Y., Wei L., Liu Y., Hu Y.-h., Peng P., Wang J.-m., Liu J., Chen Z., Li G., Zheng Z., Qiu S., Luo J., Ye C., Zhu S., Zhong N. Clinical characteristics of coronavirus disease 2019 in China // N. Engl. J. Med. 2020. Vol.382, №18. P.1708–1720. doi: 10.1056/NEJMoa2002032</mixed-citation><mixed-citation xml:lang="en">Guan W., Ni Z., Hu Yu, Liang W., Ou C., He J., Liu L., Shan H., Lei C., Hui D.S.C., Du B., Li L., Zeng G., Yuen K.-Y., Chen R., Tang C., Wang T., Chen P., Xiang J., Li S., Wang Jin-lin, Liang Z., Peng Y., Wei L., Liu Y., Hu Y.-h., Peng P., Wang J.-m., Liu J., Chen Z., Li G., Zheng Z., Qiu S., Luo J., Ye C., Zhu S., Zhong N. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 2020; 382 (18):1708–1720. doi: 10.1056/NEJMoa2002032</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rossato M., Russo L., Mazzocut S., Vincenzo A. Di, Fioretto P., Vettor R. Current smoking is not associated with COVID-19 // Eur. Respir. J. 2020. Vol.55, №6. Article number: 2001290. doi: 10.1183/13993003.01290-2020</mixed-citation><mixed-citation xml:lang="en">Rossato M., Russo L., Mazzocut S., Vincenzo A. Di, Fioretto P., Vettor R. Current smoking is not associated with COVID-19. Eur. Respir. J. 2020; 55(6):2001290. doi: 10.1183/13993003.01290-2020</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Щикота А.М., Погонченкова И.В., Турова Е.А., Рассулова М.А., Гуменюк С.А. Хроническая обструктивная болезнь легких и COVID-19: актуальные вопросы // Пульмонология. 2020. Т.30, №5. С.599–608. https://doi.org/10.18093/0869-0189-2020-30-5-599-608</mixed-citation><mixed-citation xml:lang="en">Shchikota A.M., Pogonchenkova I.V., Turova E.A., Rassulova M.A., Gumenyuk S.A. Chronic obstructive pulmonary disease and COVID-19: topical issues. Pulmonologiya 2020; 30(5):599–608 (in Russian). https://doi.org/10.18093/0869-0189-2020-30-5-599-608</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
