cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2021-80-91-99cfpd-886Research ArticleОБЗОРЫREVIEWSКлинико-иммунологические особеннности новой коронавирусной инфекции SARS-COV-2 у беременных женщин (обзор литературы)Clinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review)ЛязгиянК. С.LyazgiyanK. S.

аспирант, лаборатория механизмов этиопатогенеза и восстановительных процессов дыхательной  системы при неспецифических заболеваниях легких, 

675000, г. Благовещенск, ул. Калинина, 22

Postgraduate Student, Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases,

22 Kalinina Str., Blagoveshchensk, 675000

lyazgiyankaren@mail.ruФедеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания»Far Eastern Scientific Center of Physiology and Pathology of Respiration2021160720210809199Copyright © Лязгиян К.С., 20212021Лязгиян К.С.Lyazgiyan K.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/886

В статье представлен обзор литературы базы данных PubMed и Google Scholar о клинических и иммунологических особенностях течения новой COVID-19 у беременных женщин, вызванной SARS-CoV-2. Показано значение физиологических изменений организма беременной женщины, а именно повышение скорости метаболизма и потребления кислорода, снижение функциональной остаточной емкости, в адаптивности иммунного ответа у беременных женщин на инфекцию. Описаны факторы, такие как снижение иммунного ответа по причине полуаллогенного плода, преэклампсия, а также цитокиновый шторм в провоспалительный период беременности, позволяющие включить беременных женщин в группу риска по развитию новой COVID-19, вызванной SARSCoV-2. Анализ мировых данных литературы, касающийся клинико-иммунологических особенностей новой коронавирусной инфекции у беременных женщин, позволил сделать заключение о недостаточной степени изученности вопроса разработки эффективного метода для модулирования иммунного ответа организмом беременной женщины. 

The article provides a brief review of the PubMed and Google Scholar databases on the clinical and immunological features of the course of the COVID-19 in pregnant women caused by SARS-CoV-2. The significance of physiological changes in the body of a pregnant woman, namely, an increase in the metabolic rate and oxygen consumption, a decrease in the functional residual capacity, in the adaptability of the immune response in pregnant women to infection is shown. The factors are described that allow pregnant women to be included in the risk group for the development of a COVID-19, such as a decrease in the immune response due to a semi-allogeneic fetus, preeclampsia, as well as a cytokine storm during the pro-inflammatory period of pregnancy. The analysis of the world literature data concerning the clinical and immunological features of the new coronavirus infection in pregnant women made it possible to conclude that the issue of developing an effective method for modulating the immune response by the body of a pregnant woman is insufficiently studied. 

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The authors declare that there are no conflicts of interest present.