cfpdБюллетень физиологии и патологии дыханияBulletin Physiology and Pathology of Respiration1998-5029Дальневосточный научный центр физиологии и патологии дыхания10.36604/1998-5029-2021-80-100-114cfpd-887Research ArticleОБЗОРЫREVIEWSCOVID-19 в педиатрической популяцииCOVID-19 in pediatric populationЕвсееваГ. П.EvseevaG. P.

д-р мед. наук, зам. директора по научной работе, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

MD, PhD, DSc (Med.), Deputy Director on Scientific Work, Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, 

49/1 Voronezhskaya Str., Khabarovsk, 680022

evceewa@yandex.ruТелепневаР. С.TelepnevaR. S.

очный аспирант, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

Postgraduate student, 

49/1 Voronezhskaya Str., Khabarovsk, 680022

pupykin84@mail.ruКнижниковаЕ. В.KnizhnikovaE. V.

научный сотрудник группы молекулярно-генетической диагностики, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

Staff Scientist of Molecular Genetic Diagnostics Group, 

49/1 Voronezhskaya Str., Khabarovsk, 680022

1904lenok@mail.ruСупрунС. В.SuprunS. V.

д-р мед. наук, главный научный сотрудник группы медико-экологических проблем здоровья матери иребенка, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

MD, PhD, DSc (Med.), Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, 

49/1 Voronezhskaya Str., Khabarovsk, 680022

iomid@yandex.ruПичугинаС. В.PichuginaS. V.

канд. мед. наук, научный сотрудник группы клинической иммунологии и эндокринологии, врач-пульмонолог, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

MD, PhD (Med.), Pulmonologist, Staff Scientist the Group of Clinical Immunology and Endocrinology,

49/1 Voronezhskaya Str., Khabarovsk, 680022

iomid@yandex.ruЯковлевЕ. И.YakovlevE. I.

младший научный сотрудник группы медико-экологических проблем здоровья матери и ребенка, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

Junior Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health, 

49/1 Voronezhskaya Str., Khabarovsk, 680022

iomid@yandex.ruГалянтО. И.GalyantO. I.

канд. мед. наук, старший научный сотрудник, главный врач клиники, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

MD, PhD, Senior Staff Scientist of the Group of Clinical Immunology and Endocrinology, Chief Medical Officer, 

49/1 Voronezhskaya Str., Khabarovsk, 680022

iomid@yandex.ruКозловВ. К.KozlovV. K.

д-р мед. наук, профессор, член-корреспондент РАН, главный научный сотрудник группы медико-экологических проблем здоровья матери и ребенка, 

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

MD, PhD, DSc (Med.), Professor, Corresponding Member of RAS, Main Staff Scientist of the Group of Health and Environmental Problems of Mother and Child Health,

49/1 Voronezhskaya Str., Khabarovsk, 680022

iomid@yandex.ruЛебедькоО. А.Lebed’koO. A.

д-р мед. наук, директор Хабаровского филиала,

680022, г. Хабаровск, ул. Воронежская 49, корп. 1

MD, PhD, DSc (Med.), Director of the Khabarovsk Branch,

49/1 Voronezhskaya Str., Khabarovsk, 680022

iomid@yandex.ruХабаровский филиал Федерального государственного бюджетного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт охраны материнства и детстваKhabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection202116072021080100114Copyright © Евсеева Г.П., Телепнева Р.С., Книжникова Е.В., Супрун С.В., Пичугина С.В., Яковлев Е.И., Галянт О.И., Козлов В.К., Лебедько О.А., 20212021Евсеева Г.П., Телепнева Р.С., Книжникова Е.В., Супрун С.В., Пичугина С.В., Яковлев Е.И., Галянт О.И., Козлов В.К., Лебедько О.А.Evseeva G.P., Telepneva R.S., Knizhnikova E.V., Suprun S.V., Pichugina S.V., Yakovlev E.I., Galyant O.I., Kozlov V.K., Lebed’ko O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cfpd.elpub.ru/jour/article/view/887

Введение. Глобальное распространение во всем мире коронавирусной инфекции SARS-CoV-2 определяет необходимость изучения клинических особенностей, осложнений, внелегочных проявлений и долгосрочных последствий перенесенной инфекции у детей. В то время как описано много исследований у взрослых пациентов, имеются ограниченные данные с анализом клинического течения заболевания у педиатрических пациентов, инфицированных SARS-CoV-2. Цель. Обзор литературы, содержащей зарегистрированные в настоящее время случаи инфекции SARS-CoV-2 у детей для представления современного состояния вопроса, понимания направления исследований и нерешенных проблем. Материалы и методы. Осуществлен анализ публикаций, содержащих данные исследований случаев заболевания SARS-CoV-2 у детей. Результаты. Исследователи из разных стран сходятся во мнении, что дети менее восприимчивы к COVID-19. Это может создать опасную ситуацию, которая может привести к ослаблению внимания к детям. Хотя клинические проявления у них, в основном, представлены легкими или умеренными симптомами, тем не менее, у детей встречаются и тяжелые случаи заболевания, которые могут привести к смерти. Заключение. Сложность и вариабельность проявлений COVID-19 подтверждают гипотезу о том, что необходимы дальнейшие исследования долгосрочных и хронических симптомов COVID-19 у детей. Неспособность понять основные биологические механизмы, вызывающие эти сохраняющиеся симптомы, увеличивает упущенные возможности выявления пациентов из группы риска хронизации, с целью предотвращения таких состояний и поиска подходов реабилитации детей, перенесших COVID-19. 

Introduction. The global spread of SARS-CoV-2 coronavirus infection worldwide determines the need to study the clinical features, complications, extrapulmonary manifestations and long-term consequences of the infection in children. While many studies have been described in adult patients, there are limited data analyzing the clinical course of the disease in pediatric patients infected with SARS-CoV-2. Aim. Review of the literature containing currently reported cases of SARS-CoV-2 infection in children to present the state of the art, understand the direction of research and unresolved issues. Materials and methods. An analysis of publications containing data from studies of SARS-CoV-2 cases in children was carried out. Results. Researchers from different countries agree that children are less susceptible to COVID19. This can create a dangerous situation, which can lead to a weakening of attention to children. Although their clinical manifestations are mainly mild to moderate symptoms, nevertheless, severe cases of the disease occur in children, which can lead to death. Conclusion. The complexity and variability of COVID-19 manifestations support the hypothesis that further research is needed on the long-term and chronic symptoms of COVID-19 in children. Failure to understand the underlying biological mechanisms behind these persistent symptoms increases missed opportunities to identify patients at risk of chronicity in order to prevent such conditions and seek rehabilitation approaches for children with COVID-19. 

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The authors declare that there are no conflicts of interest present.