The role of surfactant protein SP-D in the functioning of innate and adaptive immunity in children with bronchial obstruction
https://doi.org/10.36604/1998-5029-2024-94-111-117
Abstract
Introduction. Bronchial obstruction syndrome remains a significant issue in pediatrics. One of the non-invasive diagnostic methods in children is the determination of local nonspecific immune defense indicators. Aim. To study the role of surfactant protein SP-D in the functioning of the innate and adaptive immunity in children with bronchial obstruction. Materials and methods. A total of 183 children were examined: Group 1 consisted of patients with SP-D protein concentrations ranging from 100 to 500 ng/mL (n=21), Group 2 with less than 100 ng/mL (n=92), and a control group of healthy children with SP-D levels above 500 ng/mL (n=70). All children underwent enzyme-linked immunoassay to determine the concentrations of surfactant protein SP-D in exhaled breath condensate, and levels of IgA, IgM, IgG, IgE, and α-defensins 1-3 in serum. Results. The content of IgA was found to be 44.4% and 33.3% lower in the first and second groups, respectively, compared to the control group. Higher levels of IgE were detected in Groups 1 and 2 compared to healthy children. No differences were observed in IgM and IgG levels among the study groups. The concentration of α-defensins 1-3 was 6.8 times lower in Group 1 compared to the control group, and 1.7 times lower in Group 2. Conclusion. Reduced levels of SP-D affect both innate and adaptive immunity indicators. Low SP-D protein values were associated with decreased IgA and α-defensins levels, as well as high IgE concentrations.
About the Authors
A. N. Vlasova
Chita State Medical Academy
Russian Federation
Russian Federation
Anna N. Vlasova, Assistant of Department of outpatient pediatrics with a course of medical rehabilitation
39a Gorkiy Str., Chita, 672090
E. V. Fefelova
Chita State Medical Academy
Russian Federation
Russian Federation
Elena V. Fefelova, MD, PhD, DSc (Med.), Professor of the Department of Pathophysiology
39a Gorkiy Str., Chita, 672090
N. N. Tsybikov
Chita State Medical Academy
Russian Federation
Russian Federation
Namzhil N. Tsybikov, MD, PhD, DSc (Med.), Professor, Head of the Department of Pathophysiology
39a Gorkiy Str., Chita, 672090
N. L. Potapova
Chita State Medical Academy
Russian Federation
Russian Federation
Natalia L. Potapova, MD, PhD, DSc (Med.), Associate Professor, Head of Department of outpatient pediatrics with a course of medical rehabilitation
39a Gorkiy Str., Chita, 672090
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For citations:
Vlasova A.N., Fefelova E.V., Tsybikov N.N., Potapova N.L. The role of surfactant protein SP-D in the functioning of innate and adaptive immunity in children with bronchial obstruction. Bulletin Physiology and Pathology of Respiration. 2024;(94):111-117. (In Russ.) https://doi.org/10.36604/1998-5029-2024-94-111-117
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