МЕТАБОЛИЗМ ПРОГЕСТЕРОНА В ПЛАЦЕНТЕ (ОБЗОР ЛИТЕРАТУРЫ)
https://doi.org/10.12737/article_5936356ad72dd1.30067788
Аннотация
В статье представлены современные данные о метаболизме прогестерона в плаценте. Рассмотрены ферменты, принимающие участие в преобразовании гестагенов: альдокеторедуктазы (AKR1D1, AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2), 3β- и 17β-гидроксистероиддегидрогеназы. Изложены существующие в настоящее время мнения об их существенной роли в поддержании беременности. Представлены основные метаболиты прогестерона в плаценте - 20α-дигидропрогестерон и 5α-дигидропрогестерон. Кроме этого, особое внимание в статье уделено двум другим активно изучаемым в последнее время метаболитам: 5β-дигидропрогестерону и аллопрегненолону. Подчеркнута их центральная роль: 5β-дигидропрогестерон поддерживает тонус миометрия в состоянии покоя, аллопрегненолон является ключевым нейроактивным стероидом в период жизни плода. Сделан вывод о необходимости дальнейшего исследования метаболизма прогестерона в плаценте.
Об авторах
И. В. Довжикова
Дальневосточный научный центр физиологии и патологии дыхания
Россия
Россия
М. Т. Луценко
Дальневосточный научный центр физиологии и патологии дыхания
Россия
Россия
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Рецензия
Для цитирования:
Довжикова И.В., Луценко М.Т. МЕТАБОЛИЗМ ПРОГЕСТЕРОНА В ПЛАЦЕНТЕ (ОБЗОР ЛИТЕРАТУРЫ). Бюллетень физиологии и патологии дыхания. 2017;(64):101-107. https://doi.org/10.12737/article_5936356ad72dd1.30067788
For citation:
Dovzhikova I.V., Lutsenko M.T. PROGESTERONE METABOLISM IN PLACENTA (REVIEW). Bulletin Physiology and Pathology of Respiration. 2017;(64):101-107. (In Russ.) https://doi.org/10.12737/article_5936356ad72dd1.30067788
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