LOCAL IMMUNE PROTECTION AND SYSTEM INFLAMMATORY RESPONSE AT BRONCHIAL ASTHMA IN PREGNANT WOMEN

Abstract

The parameters of humoral immunity to respiratory viruses and to the virus of cytomegalia as well as the contents of secretory immunoglobulin А(sIgA), interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and interferon-γ (INF-γ) at asthma were studied in 57 women in the third trimester of pregnancy. The first group consisted of 29 patients with mild asthma, the second one included 28 women with moderate asthma. The control group had 30 women with physiologic course of the gestation process. It is shown that in the second group 39.3% women had the reactivation of chronic cytomegalovirus infection (in the first group it was in 6.9%, р<0.05). At moderate asthma there was the decrease of sIgA till 3.1±0.26 mg/l, its concentration in healthy pregnant women was 5.7±0.49 mg/l (р<0.01). In pregnant women with mild asthma there was an increase of the concentration of IL-4 till 56.1±5.01 pg/ml, TNF-α till 171.2±11.07 pg/ml, as well as of INF-γ till 48.9±4.21 pg/ml (in the control group it was 36.7±2.05 pg/ml, p<0.001; 63.7±4.51 pg/ml, p<0.001; 46.8±3.92 pg/ml, р<0.01, respectively). In the second group in comparison with the first one there was the increase of concentration of IL-4 till 73.9±5.65 pg/ml (р<0.05) and TNF-α till 272.4±15.82 pg/ml (p<0.01), as well the decrease of INF-γ till 35.7±3.87 pg/ml (р<0.05). Identified lower values of sIgA and INF-γ suggest the decrease of antivirus immunity in women with moderate asthma in the third trimester of pregnancy.