Method for lung inflation determining in asthma patients with osmotic airway hyperresponsiveness
https://doi.org/10.36604/1998-5029-2022-86-62-67
Abstract
Aim. To develop a method for determining the lung inflation by the indexes of forced expiratory flowvolume spirometry.
Materials and methods. In 43 patients with mild persistent uncontrolled asthma in combination with osmotic airway hyperresponsiveness, the lung function indexes were assessed by spirometry using a bronchodilation test and bodyplethysmography.
Results. From the entire set of parameters, using regression analysis, two equations were constructed, with the inclusion of the main spirometric indicators (FEV1 in % of the due value, AFEVt and AFEF75 after the bronchodilation test, in %). The equations obtained make it possible to calculate lung inflation indices in asthma patients with osmotic airway hyperresponsiveness to select patients for referral for bodyplethysmography and multispiral computed tomography of the lungs in order to diagnose the severity of hyperinflation.
Conclusion. The developed regression models provide an opportunity for a preliminary assessment of the presence and degree of lung hyperinflation in asthma patients with osmotic airway hyperresponsiveness, to determine personal approaches to basic anti-inflammatory therapy and, if necessary, to correct it in a timely manner.
Keywords
Supporting agencies: The study was partially supported by the Ministry of Science and High Education of the Russian Federation (Project No. 122082400001-8)
About the Author
E. Yu. Afanas'eva
Far Eastern Scientific Center of Physiology and Pathology of Respiration; Amur State University
Russian Federation
Russian Federation
Evgeniya Yu. Afanas'eva, PhD (Med.), Junior Staff Scientist of Laboratory of Molecular and Translational Research; Staff Scientist of Laboratory of Mathematical Modeling of Complex Physical and Biological Systems
22 Kalinina Str., Blagoveshchensk, 675000
21 Ignatievskoe Highway, Blagoveshchensk, 675027
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Review
For citations:
Afanas'eva E.Yu. Method for lung inflation determining in asthma patients with osmotic airway hyperresponsiveness. Bulletin Physiology and Pathology of Respiration. 2022;(86):62-67. (In Russ.) https://doi.org/10.36604/1998-5029-2022-86-62-67
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