Multivariate regression analysis of risk factors for the development of polyposisrhinosinusitis
https://doi.org/10.36604/1998-5029-2024-93-83-90
Abstract
Introduction. Chronic rhinosinusitis with nasal polyps is a group of chronic recurrent inflammatory diseases of the nasal mucosa and paranasal sinuses with an incompletely understood etiopathogenesis. Despite various theories on the development of this disease and principles of pathogenetic therapy, some patients continue to suffer from the disease, which is resistant to both medical and surgical treatment.
The aim of this study was to identify the most significant risk factors for the development of polypoid rhinosinusitis in patients with chronic purulent rhinosinusitis using binary logistic regression.
Materials and methods. The study included patients diagnosed with chronic purulent rhinosinusitis (n=40) and chronic purulent-polypoid rhinosinusitis (n=40) who were treated at the otorhinolaryngology department of the Chita Clinical Hospital "RZD-Medicine" from 2016 to 2020. The control group consisted of 20 healthy volunteers, matched by sex and age with the study groups. All subjects underwent comprehensive clinical examinations, bacteriological analysis, endoscopic examination, and measurements of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, defensins (HAD 1-3), heat shock protein 70 (HSP70), and autoantibodies to it in serum and nasal secretions, as well as the coagulation activity of nasal secretions. Binary logistic regression was used to analyze risk factors for the development of polypoid rhinosinusitis.
Results. We demonstrated that high predictive significance for the development of nasal mucosal polyps in patients with purulent rhinosinusitis is associated with concentrations of heat shock protein 70, IL-10, and HAD 1-3 in serum.
Conclusion. A test set that includes levels of HSP70, IL-10, and HAD 1-3 in serum can predict the development of chronic polypoid rhinosinusitis with 99% accuracy.
About the Authors
M. O. Ivanov
Chita State Medical Academy
Russian Federation
Russian Federation
Mikhail O. Ivanov, Postgraduate student, Department of the Pathological Physiology
39a Gorkiy Str., Chita, 672000
E. V. Egorova
Chita State Medical Academy
Russian Federation
Russian Federation
Elena V. Egorova, MD, PhD, DSc (Med.), Head of the Department of Otolaryngology
39a Gorkiy Str., Chita, 672000
E. V. Fefelova
Chita State Medical Academy
Russian Federation
Russian Federation
Elena V. Fefelova, MD, PhD, DSc (Med.), Professor of the Department of Pathological Physiology
39a Gorkiy Str., Chita, 672000
N. N. Tsybikov
Chita State Medical Academy
Russian Federation
Russian Federation
Namzhil N. Tsybikov, MD, PhD, DSc (Med.), Professor, Head of the Department of Pathological Physiology
39a Gorkiy Str., Chita, 672000
References
1. Amirapu S., Biswas K., Radcliff F.J., Wagner Mackenzie B., Ball S., Douglas R.G. Sinonasal tissue remodelling during chronic rhinosinusitis. Int. J. Otolaryngol. 2021; 2021:7428955. https://doi.org/10.1155/2021/7428955
2. Shaghayegh G., Cooksley C., Ramezanpour M., Wormald P.J., Psaltis A.J., Vreugde S. Chronic rhinosinusitis, S. aureus biofilm and secreted products, inflammatory responses, and disease severity. Biomedicines 2022; 10(6):1362. https://doi.org/10.3390/biomedicines10061362
3. Carsuzaa F., Béquignon É., Dufour X., de Bonnecaze G., Lecron J.C., Favot L. Cytokine signature and involvement in chronic rhinosinusitis with nasal polyps. Int. J. Mol. Sci. 2021; 23(1):417. https://doi.org/10.3390/ijms23010417
4. Tsybikov N.N., Egorova E.V., Fefelova E.V., Kuznik B.I., Magen E. Heat shock protein 70 and anti-heat shock protein 70 antibodies in nasal secretions of patients with chronic rhinosinusitis. Allergy Rhinol. (Providence) 2016; 7(1):14– 20. https://doi.org/10.2500/ar.2016.7.0149
5. Tsybikov N.N., Kuznik B.I., Egorova E.V., Fefelova E.V., Magen E. Anticytokine autoantibodies in chronic rhinosinusitis. Allergy Asthma Proc. 2015; 36(6):473–480. https://doi.org/10.2500/aap.2015.36.3880
6. Jonstam K., Alsharif S., Bogaert S., Suchonos N., Holtappels G., Jae-Hyun Park J., Bachert C. Extent of inflammation in severe nasal polyposis and effect of sinus surgery on inflammation. Allergy 2021; 76(3):933–936. https://doi.org/10.1111/all.14550
7. Ishikawa C., Takeno S., Okamoto Y., Kawasumi T., Kakimoto T., Takemoto K., Nishida M., Ishino T., Hamamoto T., Ueda T., Tanaka A. Oncostatin M's involvement in the pathogenesis of chronic rhinosinusitis: focus on type 1 and 2 inflammation. Biomedicines 2023; 11(12):3224. https://doi.org/10.3390/biomedicines11123224
8. Viksne R.J.; Sumeraga G., Pilmane M. Antimicrobial and defense proteins in chronic rhinosinusitis with nasal polyps. Medicina (Kaunas) 2023; 59:1259. https://doi.org/10.3390/medicina59071259
9. Kumar P., Kizhakkedathu J.N., Straus S.K. Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo. Biomolecules 2018; 8(1):4. https://doi.org/10.3390/biom8010004
10. Santacroce L., Topi S., Charitos I.A., Lovero R., Luperto P., Palmirotta R., Jirillo E. Current views about the inflammatory damage triggered by bacterial superantigens and experimental attempts to neutralize superantigen-mediated toxic effects with natural and biological products. Pathophysiology 2024; 31(1):18–31. https://doi.org/10.3390/pathophysiology31010002
11. Fu J., Zong X., Jin M., Min J., Wang F., Wang Y. Mechanisms and regulation of defensins in host defense. Signal Transduct. Target. Ther. 2023; 8(1):300.bhttps://doi.org/10.1038/s41392-023-01553-x
12. Brook M., Tomlinson G.H., Miles K., Smith R.W., Rossi A.G., Hiemstra P.S., van't Wout E.F., Dean J.L., Gray N.K., Lu W., Gray M. Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation. Proc. Natl. Acad. Sci. USA. 2016; 113(16):4350–4355. https://doi.org/10.1073/pnas.1601831113
13. Mudrov V.A. [ROC curve analysis algorithm in biomedical research using SPSS software package]. Zabaykal'skiy meditsinskiy vestnik = Transbaikalian Medical Bulletin 2021; 1:148–153 (in Russian). https://doi.org/10.52485/19986173_1_148
14. Nazari J., Shahba F., Jafariaghdam N., Mohebbi S., Arshi S., Bemanian M.H., Fallahpour M., Shokri S., Atashrazm F., Amini S., Roomiani M., Jamee M., Babaheidarian P., Khoshmirsafa M., Nabavi M. Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups. Allergy Asthma Clin. Immunol. 2024; 20(1):14. https://doi.org/10.1186/s13223-024-00876-w
15. Alnemare A.K., Almutairi A.B., Almutairi A.F., Bin Mahfoz T., Almutairi S.B., Alnemare A.K., Almjlad R.B., Alhumam M.N., Alghassab R.E. Prevalence of risk factors of chronic rhinosinusitis with nasal polyps among the Saudi population. Cureus 2023; 15(9):e45420. https://doi.org/10.7759/cureus.45420
16. Tsybikov N.N., Egorova E.V., Fefelova E.V., Kuznik B.I., Magen E. Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: endothelin-1, TARC/CCL17, neopterin, and α-defensins. Allergy Asthma Proc. 2016; 37(1):35–42. https://doi.org/10.2500/aap.2016.37.3899
17. Gong X., Han Z., Fan H., Wu Y., He Y., Fu Y., Zhu T., Li H. The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions. Front. Immunol. 2023; 14:1238673. https://doi.org/10.3389/fimmu.2023.1238673
Review
For citations:
Ivanov M.O., Egorova E.V., Fefelova E.V., Tsybikov N.N. Multivariate regression analysis of risk factors for the development of polyposisrhinosinusitis. Bulletin Physiology and Pathology of Respiration. 2024;(93):83-90. (In Russ.) https://doi.org/10.36604/1998-5029-2024-93-83-90
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