METHOD FOR ASSESSING OF SEVERITY OF SYMPTOMS OF THE ENDOGENOUS INTOXICATION SYNDROME AND ASSOCIATED RESPIRATORY DISORDERS IN PATIENTS WITH COLORECTAL CANCER

The purpose of the research is to develop a method for assessing the severity of symptoms of the endogenous intoxication syndrome and associated respiratory disorders in patients with colorectal cancer. The study involved 86 patients (the main group included 51 patients with colorectal cancer, the control group 35 relatively healthy people). All patients were studied upon indicators of clinical blood test, and hematological indices of intoxication were calculated. In the patients of the main group, an assessment of the oxygen status parameters was done. The study revealed that 52.9% of patients with colorectal cancer have symptoms of endogenous intoxication syndrome and respiratory disorders of varying severity, which are accompanied by decrease in oxygen delivery to tissues, its increased consumption and utilization. As a result of the study, there was proposed a method for calculation of the integral index of intoxication as a parameter of expression of endogenous intoxication and associated respiratory disorders. Statistically significant values of the correlation coefficients of the proposed indicator of intoxication and oxygen status parameters suggest a high diagnostic significance of this index in patients with colorectal cancer. Moreover, the application of this method in everyday practice is simple for the doctor and safe for the patient.

endogenous intoxication, leukocyte intoxication index, respiratory disorders, respiratory failure, oxygen status, colorectal cancer, preoperative period

1. Дмитриенко М.М., Осыко Я.А., Кулигин А. В. Роль соотношения форменных элементов крови при синдроме эндогенной интоксикации // Вестник современной клинической медицины. 2013. Т.6, №5. С.145-149.

2. Добрых В.А., Овчинникова Л.А., Тен Т.К., Уварова И.В., Онищенко И.В. Особый тип количественных отношений гранулоцитов и лимфоцитов периферической крови у пациентов с критическими состояниями // Дальневосточный медицинский журнал. 2013. №3. С.98-102.

3. Медведева М.А. Роль эндогенной интоксикации при острой кишечной непроходимости // Бюллетень медицинских интернет-конференций. 2012. Т.2, №2. С.144.

4. Свистунов Н.Н., Осипов В.А., Шульга А.Ф., Терских Н.В., Пирогов А.В. Прогностическое значение оценки тяжести состояния больных осложненным колоректальным раком // Вестник СПбГУ. 2011. Сер.11, №1. С.128-134.

5. Способ выявления симптомов эндогенной интоксикации и ассоциированных дыхательных расстройств: Пат. 2553359 RU / авторы и заявители С.В.Ходус, В.В.Яновой, С.В.Аникин, К.В.Пустовит; патентообладатель Амурская государственная медицинская академия; заявл. 07.05.2013; опубл. 06.10.2015. Бюл. №16.

6. Abakay O., Tanrikulu A.C., Palanci Y., Abakay A. The value of inflammatory parameters in the prognosis of malignant mesothelioma // J. Int. Med. Res. 2014. Vol.42, №2. P.554-565.

7. Azab B., Mohammad F., Shah N., Vonfrolio S., Lu W., Kedia S., Bloom S.W. The value of the pretreatment neutrophil lymphocyte ratio vs. platelet lymphocyte ratio in predicting the long-term survival in colorectal cancer // Cancer Biomark. 2014. Vol.14, №5. P.303 -312.

8. Boyle M.S., Bennett M., Keogh G.W., O'Brien M., Flynn G., Collins D.W., Bihari D. Central venous oxygen saturation during high-risk general surgical procedures-relationship to complications and clinical outcomes // Anaesth. Intensive Care. 2014. Vol.42, №1. P.28-36.

9. Formica V., Luccchetti J., Cunningham D., Smyth E.C., Ferroni P., Nardecchia A., Tesauro M., Cereda V., Guadagni F., Roselli M. Systemic inflammation, as measured by the neutrophil/lymphocyte ratio, may have differential prognostic impact before and during treatment with fluorouracil, irinotecan and bevacizumab in metastatic colorectal cancer patients // Med. Oncol. 2014. Vol.31, №9. P.166.

10. McNamara M.G., Templeton A.J., Maganti M., Walter T., Horgan A.M., McKeever L., Min T., Amir E., Knox J.J. Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer // Eur. J. Cancer. 2014. Vol.50, №9. P.158-159.

11. Ozdemir Y., Akin M.L., Sucullu I., Balta A.Z., Yucel E. Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer // Asian Pac. J. Cancer Prev. 2014. Vol.15, №6. P.2647-2650.

12. Schietroma M., Pessia B., Carlei F., Cecilia E.M., Amicucci G. Intestinal permeability, systemic endotoxemia, and bacterial translocation after open or laparoscopic resection for colon cancer: a prospective randomized study // Int. J. Colorectal Dis. 2013. Vol.28, №12. P.1651-1660.

13. Viers B.R. Boorjian S.A., Frank I., Tarrell R.F., Thapa P., Karnes R.J., Thompson R.H, Tollefson M.K. Pretreatment neutrophil-to-lymphocyte ratio in associated with advanced pathologic tumor stage and increased cancer-specific mortality among patients with ureteral carcinoma of the bladder undergoing radical cystectomy // Eur. Urol. 2014. Vol.66, №6. P.1157-1164.