Chronic bronchopulmonary diseases in children: developmental characteristics and clinical course
https://doi.org/10.36604/1998-5029-2025-96-18-32
Abstract
This lecture summarises long-term clinical observations of children with various forms of chronic non-specific lung diseases (CNLD), which have enabled the author to formulate a concept of dysontogenetic disorders of the bronchopulmonary system arising at both prenatal and postnatal levels. Such disorders develop through biochemical, molecular and cellular changes triggered by a combination of exogenous and endogenous damaging factors – nutrient and essential-trace-element deficiency or imbalance, intrauterine viral infection and environmental exposures – that programme physiological and metabolic reactions from the earliest stages of bronchopulmonary organogenesis through to adult life. This approach opens up possibilities for a scientifically grounded primary prevention of dysontogenetically determined pulmonary pathology in children. The author presents a differential diagnostic algorithm for analyzing recurrent and chronic bronchopulmonary pathology.
Keywords
chronic bronchopulmonary diseases,
pathogenesis,
morphogenesis,
nosological variants,
congenital malformations of the lungs,
metabolic imprinting,
children
Supporting agencies: This study was not sponsored
About the Author
V. K. Kozlov
Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Research Institute of Maternity and Childhood Protection
Russian Federation
Russian Federation
Vladimir K. Kozlov, MD, PhD, DSc (Med.), Professor, Corresponding Member of RAS, Main Staff Scientist
Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research; Group of Health and Environmental Problems of Mother and Child Health
680022; 49/1 Voronezhskaya Str.; Khabarovsk
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For citations:
Kozlov V.K. Chronic bronchopulmonary diseases in children: developmental characteristics and clinical course. Bulletin Physiology and Pathology of Respiration. 2025;(96):18-32. (In Russ.) https://doi.org/10.36604/1998-5029-2025-96-18-32
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