PREOPERATIVE CORRECTION OF SYMPTOMS OF ENDOGENOUS INTOXICATION AND VIOLATIONS OF THE OXYGEN STATUS IN PATIENTS WITH COLORECTAL CANCER

The purpose of the study is to propose a method of preoperative correction of the symptoms of endogenous intoxication syndrome and associated respiratory disorders in patients with colorectal cancer. The study involved 68 patients having a surgery for colorectal cancer of different localization, with an increased leukocyte index of intoxication by V.K.Ostrovsky in preoperative period. The first group patients (37 subjects) in the preoperative preparation program took Cytoflavin^® according to the developed scheme. The second group patients (31 subjects) had a standard preoperative preparation. As result of the research, there was revealed a positive effect of the proposed method of preoperative preparation on hematological parameters of endogenous intoxication (decrease in values of the parameters of Calf-Caliph, Ostrovsky and integral index of intoxication) and parameters of oxygen status, which changes indicated a decrease in tissue hypoxia (decrease in tissue oxygen consumption). The positive effect of the proposed method of preoperative preparation was observed in the postoperative period (reduced severity of respiratory disorders and hematological symptoms of endogenous intoxication).

endogenous intoxication, respiratory disorders, respiratory failure, oxygen status, colorectal cancer, preoperative period, succinic acid, preoperative preparation

1. Лукьянова Л.Д. Современные проблемы адаптации к гипоксии. Сигнальные механизмы и их роль в системной регуляции // Патологическая физиология и экспериментальная терапия. 2011. №1. С.3-19.

2. Туманян С.В., Иванова Л.Г. Антиоксидантная защита как компонент анестезиологического обеспечения онкологических больных // Хирургия. Журнал им. Н.И.Пирогова. 2011. №6. С.66-69.

3. Способ предоперационной коррекции дыхательных расстройств у больных колоректальным раком. Пат. 2526828 RU / авторы и заявители С.В.Ходус, В.В.Яновой, С.В.Аникин, К.В.Пустовит; патентообладатель Амурская государственная медицинская академия; заявл. 30.04.2013; опубл. 27.08.2014. Бюл. №24.

4. Способ выявления симптомов эндогенной интоксикации и ассоциированных дыхательных расстройств: Пат. 2553359 RU / авторы и заявители С.В.Ходус, В.В.Яновой, С.В.Аникин, К.В.Пустовит; патентообладатель Амурская государственная медицинская академия; заявл. 07.05.2013; опубл. 06.10.2015. Бюл. №16.

5. Bhagat S.S., Ghone R.A., Suryakar A.N., Hundekar P.S. Lipid peroxidation and antioxidant vitamin status in colorectal cancer patients // Indian J. Physiol. Pharmacol. 2011. Vol.55, №1. P.72-76.

6. Boyle M.S., Bennett M., Keogh G.W., O'Brien M., Flynn G., Collins D.W., Bihari D. Central venous oxygen saturation during high-risk general surgical procedures-relationship to complications and clinical outcomes // Anaesth. Intensive Care. 2014. Vol.42, №1. P.28-36.

7. Choi S.B. Park H. K., Hong J.H., Kim B.G., Kang H. Postoperative respiratory complications and peak airway pressure during laparoscopic colectomy in patients with colorectal cancer // Surg. Laparosc. Endosc. Percutan Tech. 2015. Vol.25, №1. P.83-88.

8. Ohigahi S., Sudo K., Kobayashi D., Takahashi T., Nomoto K., Onodera H. Significant changes in the intestinal environment after surgery in patients with colorectal cancer // J. Gastrointestinal Surg. 2013. Vol.17, №9. P.1657-1664.

9. Schietroma M., Pessia B., Carlei F., Cecilia E.M., Amicucci G. Intestinal permeability, systemic endotoxemia, and bacterial translocation after open or laparoscopic resection for colon cancer: a prospective randomized study // Int. J. Colorectal Dis. 2013. Vol.28, №12. P.1651-1660.

10. Stepien R., Gluszek S., Koziel D., Kaczmarczyk M. The risk of surgical treatment in patients aged 85+, with special consideration of colorectal cancer // Pol. Prezegl. Chir. 2014. Vol.86, №3. P.132-140.

11. Wydra J., Kruszewski W., Jasiński W., Szajewski M., Ciesielski M., Szefel J., Walczak J. Is age a risk factor of postoperative complications in colorectal cancer? // Pol. Przegl. Chir. 2013. Vol.85, №9. P.491-495.