Clinical and laboratory markers for assessing insulin resistance in patients with mild obstructive sleep apnea
https://doi.org/10.36604/1998-5029-2026-100-46-55
Abstract
Aim. Based on the analysis of clinical and instrumental data in patients with mild obstructive sleep apnea (OSA) (n = 102), to identify markers associated with insulin resistance and evaluate their prognostic significance.
Materials and methods. The retrospective study included 102 men aged 30–55 years (median 44 [40–50]) with mild OSA (apneahypopnea index [AHI] ≥5 and <15 events/hour) and metabolic disorders, examined between 2018 and 2020. Markers of insulin resistance were identified using simple logistic regression with stepwise inclusion and exclusion of predictors.
Results. The most informative indicators of insulin resistance in patients with mild OSA were: excessive daytime sleepiness ≥9 points; AHI ≥11/hour; nocturnal desaturation index ≥3.6/hour; time spent with oxygen saturation below 90% ≥0.9% of total sleep time; mean nocturnal oxygen saturation ≤94%; minimum nocturnal oxygen saturation ≤85%; maximum nocturnal heart rate ≥95 bpm; and reactive hyperemia index ≤1.7.
Conclusion. These parameters may be considered accessible markers of insulin resistance in patients with mild OSA.
About the Authors
V. S. Borovitsky
Federal State Institution "Research Institute of the Federal Penitentiary Service"
Russian Federation
Russian Federation
Vladislav S. Borovitsky, MD, PhD, DSc (Med.), Main Staff Scientist
building 1, 15a Narvskaya Str., Moscow, 125130
S. L. Babak
Federal State Budgetary Educational Institution of Higher Education "Russian University of Medicine" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Sergey L. Babak, MD, PhD, DSc (Med.), Associate Professor, Pulmonologist, Professor of the Department of Phthisiology and Pulmonology of the N.A. Semashko
4 Dolgorukovskaya Str., Moscow, 127006
M. V. Gorbunova
Federal State Budgetary Educational Institution of Higher Education "Russian University of Medicine" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Marina V. Gorbunova, MD, PhD, DSc (Med.), Pulmonologist, Associate Professor of the Department of Phthisiology and Pulmonology, N.A. Semashko
4 Dolgorukovskaya Str., Moscow, 127006
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Review
For citations:
Borovitsky V.S., Babak S.L., Gorbunova M.V. Clinical and laboratory markers for assessing insulin resistance in patients with mild obstructive sleep apnea. Bulletin Physiology and Pathology of Respiration. 2026;(100):46-55. (In Russ.) https://doi.org/10.36604/1998-5029-2026-100-46-55
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