Use of daratumumab in first-line therapy for multiple myeloma
https://doi.org/10.36604/1998-5029-2026-100-145-155
Abstract
Introduction. Multiple myeloma (MM) is one of the most common hematologic malignancies.
Aim. To demonstrate the potential of using the targeted monoclonal antibody daratumumab in patients with newly diagnosed MM.
Materials and methods. Two clinical cases illustrating the efficacy and safety of daratumumab-based regimens in newly diagnosed MM are presented.
Results. Both patients received first-line therapy including daratumumab. The first patient was treated according to the Dara-Vd protocol (daratumumab, bortezomib, dexamethasone), while the second received Dara-Rd (daratumumab, lenalidomide, dexamethasone). The choice of regimen was guided by baseline disease status and the presence of osteolytic bone lesions. Both patients achieved a partial response, followed by autologous stem cell transplantation (aHSCT). Subsequently, consolidation therapy with daratumumab-containing protocols was administered, resulting in complete remission of MM.
Conclusion. These clinical cases illustrate the high efficacy of daratumumab in first-line treatment of MM in aHSCT-eligible patients and the possibility of achieving a response after 3–6 cycles of therapy.
About the Authors
V. V. Voytsekhovskiy
Amur State Medical Academy
Russian Federation
Russian Federation
Valeriy V. Voytsekhovskiy, MD, DSc (Med.), Professor, Head of Department of Hospital Therapy with Pharmacology Course named after Professor Yu.S. Landyshev
95 Gor'kogo Str., Blagoveshchensk, 675000
T. V. Еsenina
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Tatiana V. Еsenina, MD, Head of Department of Hematology
26 Voronkova Str., Blagoveshchensk, 675028
E. A. Filatova
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Ekaterina A. Filatova, MD, PhD (Med.), Hematologist of Department of Hematology
26 Voronkova Str., Blagoveshchensk, 675028
N. А. Fedorova
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Natalia А. Fedorova, MD, Hematologist of Department of Hematology
26 Voronkova Str., Blagoveshchensk, 675028
I. A. Kornilovich
Amur State Medical Academy
Russian Federation
Russian Federation
Iuliia A. Kornilovich, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
V. R. Shelestova
Amur State Medical Academy
Russian Federation
Russian Federation
Valeria R. Shelestova, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
E. I. Beliaeva
Amur State Medical Academy
Russian Federation
Russian Federation
Ekaterina I. Beliaeva, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
K. Zh. Saidova
Amur State Medical Academy
Russian Federation
Russian Federation
Kamila Zh. Saidova, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
S. V. Ishchenko
Amur State Medical Academy
Russian Federation
Russian Federation
Sergey V. Ishchenko, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
Yu. N. Glyzina
Amur State Medical Academy
Russian Federation
Russian Federation
Yulia N. Glyzina, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
T. V. Sheshera
Amur State Medical Academy
Russian Federation
Russian Federation
Taisiia V. Sheshera, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
V. A. Bogdanovich
Amur State Medical Academy
Russian Federation
Russian Federation
Vladislav A. Bogdanovich, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
V. S. Strelnikova
Amur State Medical Academy
Russian Federation
Russian Federation
Vlada S. Strelnikova, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
I. S. Kuznetsov
Amur State Medical Academy
Russian Federation
Russian Federation
Ilia S. Kuznetsov, 6th year Student
95 Gor'kogo Str., Blagoveshchensk, 675000
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Voytsekhovskiy V.V., Еsenina T.V., Filatova E.A., Fedorova N.А., Kornilovich I.A., Shelestova V.R., Beliaeva E.I., Saidova K.Zh., Ishchenko S.V., Glyzina Yu.N., Sheshera T.V., Bogdanovich V.A., Strelnikova V.S., Kuznetsov I.S. Use of daratumumab in first-line therapy for multiple myeloma. Bulletin Physiology and Pathology of Respiration. 2026;(100):145-155. (In Russ.) https://doi.org/10.36604/1998-5029-2026-100-145-155
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