INFLUENCE OF THE COURSE OF INHALATION WITH PROPOLIS, ROYAL JELLY AND “APINGALIN” MEDICATION ON ENEGRY METABOLISM AT EXPERIMENTAL PULMONARY EDEMA IN RATS

The purpose of the research is to study the impact of the course of inhalation with propolis, royal jelly and their mixture in "Apingalin" medication on some indicators of energy metabolism in experimental pulmonary edema in rats. Blood plasma of 90 white male rats weighing 0.15-0.2 kg was studied. The animals were divided into groups: intact animals; control animals to which adrenal pulmonary edema (epinephrine was administered intraperitoneally at a dose of 0.5 mg/kg) was introduced; propolis, royal jelly, Apingalin animals with pulmonary edema, which then had a course of inhalation with propolis, royal jelly and Apingalin (10 days by 10 minutes), respectively. The collection of biological material was carried out at the 11th day after the start of the experiment. The intensity of energy processes was evaluated by the level of glucose, lactate, creatinine, LDH activity, phosphorous compounds quantity in blood plasma of experimental animals. It was found out that in experimental pulmonary edema in rats anaerobic glycolysis is enhanced alongside with the collapse of creatine phosphate, which causes corresponding changes in biochemical homeostasis, n.e. the increase of concentration of lactate, creatinine, and the reduction of blood glucose concentrations. Inhalations with royal jelly and Apingalin allow to eliminate the consequences of the violation of energy metabolism after experimental pharmacological shock most effectively, inhalations with propolis do it less effectively.

royal jelly, bee propolis, lungs, energy metabolism, LDH, lactate, creatinine, organic phosphorus compounds

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