EFFICIANCY OF IMMUNOTHERAPY IN PATIENTS WITH PERSISTENT ALLERGIC RHINITIS
https://doi.org/10.12737/article_5c1264ee93f132.73406573
Abstract
The dynamics of parameters of cytokine status in patients with allergic rhinitis in view of efficiency of allergen-specific immunotherapy (ASIT) was studied in this work. 62 subjects with moderate persistent rhinitis at the age of 18-40 years old were included in the study. For specific diagnosis and treatment there we used standard allergens. ASIT was performed by the classical scheme. The concentrations of IL-4, IL-5, IL-6, IL-8 in the blood serum were measured by the enzyme immunoassay. A good or excellent effect of treatment with ASIT was achieved in 62.9% of cases, and satisfactory one in 37.1% of cases. The analysis of the dynamics of IL-4, IL-5, IL-6, IL-8 concentrations showed that the efficiency of ASIT in patients with allergic rhinitis depends on the ability of the immune system to activation by low doses of the allergen, quite fast suppression of proinflammatory cytokines induced by them, and active functioning of the system of anti-inflammatory cytokines.
About the Authors
M. V. Antonyuk
Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
S. F. Suleymanov
Bukhara State Medical Institute
Russian Federation
Russian Federation
T. A. Gvozdenko
Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
T. P. Novgorodtseva
Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
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Review
For citations:
Antonyuk M.V., Suleymanov S.F., Gvozdenko T.A., Novgorodtseva T.P. EFFICIANCY OF IMMUNOTHERAPY IN PATIENTS WITH PERSISTENT ALLERGIC RHINITIS. Bulletin Physiology and Pathology of Respiration. 2018;(70):32-37. (In Russ.) https://doi.org/10.12737/article_5c1264ee93f132.73406573
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