SUCCINATE CONTAINING DRUG FOR CORRECTION OF LIPID PEROXIDATION PROCESSES INDUCED BY ADMINISTRATION OF THE CARBON TETRACHLORIDE

At present in the clinical practice compounds of succinic acid which have antioxidant and cytoprotective properties are used as pharmacologically active substances with a wide range of biological activity. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the administration of the succinate containing drug called Remaxol^® (Polysan, St. Petersburg). The animals were divided into 4 groups and each of them had 20 rats: the group with intact animals which were held in standard conditions of vivarium; the control group in which rats were given carbon tetrachloride during 3 days daily; the experimental group in which before the introduction of carbon tetrachloride animals had a daily intra-abdominal intake of Remaxol in a dose of 50 mg/kg; the experimental group in which before the introduction of carbon tetrachloride animals had a daily intra-abdominal intake of the Remaxol in a dose of 100 mg/kg. It was found out that in the blood of experimental animals the administration of carbon tetrachloride during 3 days contributes to the increase of lipid hydroperoxides level (by 20-24%), of diene conjugate (by 17-19%), and of malonic dialdehyde (by 51-59%) against the decrease of antioxidant system activity in the blood of intact animals. The administration of the succinate containing drug to rats in the conditions of oxidative stress contributes to decrease in the blood of lipid hydroperoxides by 7-12%, of diene conjugates by 7-11%, and of malonic dialdehyde by 13-24% in comparison with the rats of the control group. While analyzing the effect of the succinate containing drug on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood of animals was significantly higher by 9-24%, of vitamin E by 12-21%, of catalase by 13-24% in comparison with the same parameters of the rats of the control group. So, the application of the succinate containing drug called Remaxol in the conditions of administration of carbon tetrachloride into the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.

succinate containing drug, Remaxol, carbon tetrachloride, biological membranes lipid peroxidation, products of peroxidation (lipid hydroperoxides, diene conjugates, malonic dialdehyde), antioxidant system

1. Dorovskikh V.A., Simonova N.V., Simonova I.V., Shtarberg M.A. Adaptogeny rastitel'nogo proiskhozhdeniya v profilaktike zabolevanii organov dykhaniya u detei yasel'nogo vozrasta // Dal'nevostochnyi meditsinskii zhurnal. 2011. №1. S.41-44.

2. Dorovskikh V.A., Simonova N.V., Li O.N., Dorovskikh V.Yu., Shtarberg M.A., Landyshev S.Yu., Mishuk V.P., Savinova T.A. Vliyanie suktsinatsoderzhashchikh preparatov na intensivnost' protsessov peroksidatsii v usloviyakh kholodovogo vozdeistviya // Byulleten' fiziologii i patologii dykhaniya. 2013. Vyp.50. S.56-60.

3. Dorovskikh V.A., Simonova N.V., Dorovskikh Yu.V., Li O.N. Korrektsiya kholodovogo vozdeistviya s pomoshch'yu preparata, soderzhashchego yantarnuyu kislotu // Byulleten' fiziologii i patologii dykhaniya. 2013. Vyp.49. S.82-86.

4. Dorovskikh V.A., Tseluiko S.S., Simonova N.V., Anokhina R.A. V mire antioksidantov. Blagoveshchensk: AGMA, 2012. 106 s.

5. Kushnerova N.F., Fedoreev S.A., Fomenko S.E., Sprygin V.G., Kulesh N.I., Mishchenko N.P., Veselova M.V., Momot T.V. Gepatoprotektornye svoistva izoflavonoidov iz kornei Maackia amurensis pri eksperimental'nom porazhenii pecheni chetyrekhkhloristym uglerodom // Eksperimental'naya i klinicheskaya farmakologiya. 2014. T.77, №2. S.26-30.

6. Pavelkina V.F., Ampleeva N.P. Sravnitel'naya effektivnost' gepatotropnoi aktivnosti remaksola i essentsiale N pri khronicheskikh virusnykh gepatitakh // Eksperimental'naya i klinicheskaya farmakologiya. 2014. T.77, №12. S.17-21.

7. Simonova N.V., Dorovskikh V.A., Shtarberg M.A. Vliyanie nastoya na osnove sbora iz list'ev krapivy, berezy i podorozhnika na intensivnost' protsessov peroksidatsii v usloviyakh ul'trafioletovogo oblucheniya // Byulleten' fiziologii i patologii dykhaniya. 2012. Vyp.44. S.90-94.

8. Simonova N.V., Dorovskikh V.A., Shtarberg M.A. Vliyanie adaptogenov rastitel'nogo proiskhozhdeniya na intensivnost' protsessov perekisnogo okisleniya lipidov biomembran v usloviyakh ul'trafioletovogo oblucheniya // Dal'nevostochnyi meditsinskii zhurnal. 2010. №2. S.112-115.

9. Simonova N.V., Dorovskikh V.A., Simonova N.P. Ul'trafioletovoe obluchenie i okislitel'nyi stress. Vozmozhnosti fitokorrektsii. Blagoveshchensk: Dal'GAU, 2014. 140 s.

10. Simonova N.V., Dorovskikh V.A., Li O.N., Shtarberg M.A., Simonova N.P. Nastoi lekarstvennykh rastenii i okislitel'nyi stress v usloviyakh kholodovogo vozdeistviya // Byulleten' fiziologii i patologii dykhaniya. 2013. Vyp.48. S.76-80.