INFLUENCE OF THE MIXTURE OF HERBAL ADAPTOGENS ON THE SEARCH ACTIVITY OF RATS DURING HEATING AND COOLING OF THE BODY
https://doi.org/10.12737/article_58e45971c2b736.56252605
Abstract
In the experiment the effect of adaptogenic herbal blend of Hypericum perforatum and Rhodiola rosea on the parameters of the search activity of laboratory rats against the background of high and low temperatures was investigated. The experiment was performed in the tool installation (N.R.Grigoriev, 1998), which is the universal problematic camera, with application of the mixture of herbal adaptogens from Hypericum perforatum and Rhodiola rosea in a dose of 30 mg/kg; 150 mg/kg; 300 mg/kg in rats exposed to prolonged heat and cold stress. The tests were carried out on 100 white mongrel male rats weighing 180-200 g. The following indicators of the search activity were subject to registration: 1) motivation-energy parameters (search time and search intensity - the number of targeted paces of rats from the camera for 60 seconds); 2) the parameters of the cognitive sphere (the cognitive index and the coefficient of the erroneous strategy of paces). It was found out that the mental capacity of animals is reduced under the effect of the temperature factor on the body. Powdery mixture of plant adaptogens of Hypericum perforatum and Rhodiola rosea in doses of 150-300 mg/kg significantly improved the cognitive characteristics of the search activity in the conditions of cold and heat stress on the body.
About the Authors
E. A. Litovchenko
Amur State Medical Academy
Russian Federation
Russian Federation
N. V. Korshunova
Amur State Medical Academy
Russian Federation
Russian Federation
T. A. Batalova
Amur State Medical Academy
Russian Federation
Russian Federation
References
1. Баталова Т.А., Бородавкин П.В., Доровских В.А., Пластинин М.Л., Сергиевич А.А., Коротеев М.П., Нифантьев Э.Е., Коротеев А.М. Влияние введения антиоксидантов на способность крыс к обучению в модульном устройстве // Дальневосточный медицинский журнал. 2009. №4. С.104-106.
2. Григорьян Г.А. Общая когнитивная способность. Некоторые новые подходы к ее исследованию у мышей // Журнал высшей нервной деятельности. 2004. №6. С.842-850.
3. Доровских В.А., Воронин Н.И., Коршунова Н.В. Холод. Адаптация. Коррекция изменений. Благовещенск, 1998. 104 с.
4. Павлов А.С., Павлова Т.В. Морфологические и физиологические показатели динамики тепловой адаптации // Физиология человека. 1992. Т.18, №2. С.108-113.
5. Grigoryev N.R., Dorovskiich V.A., Plastinin M.L. Experimental discovery cognitive and anxiolytic propeties of antioxydants and the other drugs by means of device and way patented of Amur State Medical Academy / China and Russia Pharmaceutical Forum. Studies or Drugs Used in traditional Therapy. Harbin, China. 2004. P.31-35.
6. McArthur R., Borsini F. Animal models of depression in drug discovery: a historical perspective // Pharmacol. Biochem. Behav. 2006. Vol.84, №3. P.436-452.
7. Moragreda I., Carmen Carrasco M., Redolat R. Effects of housing and nicotine on shuttle-box avoidance in male NMRI mice // Behav. Brain Res. 2005. Vol.164, №2. P.178-187.
8. Silva R.H., Frussa-Filho R. The plus-maze discriminative avoidance task: a new model to study memory-anxiety interaction. Effect of chlordiazepoxide and caffeine // J. Neurosci. Methods. 2000. Vol.102, №2. P.117-125.
Review
For citations:
Litovchenko E.A., Korshunova N.V., Batalova T.A. INFLUENCE OF THE MIXTURE OF HERBAL ADAPTOGENS ON THE SEARCH ACTIVITY OF RATS DURING HEATING AND COOLING OF THE BODY. Bulletin Physiology and Pathology of Respiration. 2017;(63):80-84. (In Russ.) https://doi.org/10.12737/article_58e45971c2b736.56252605
Views:
146
Email this article 