PATHOGENETIC ASPECTS OF THE PHENOTYPE OF BRONCHIAL ASTHMA ASSOCIATED WITH OBESITY
Abstract
Currently, in parallel with the increase in the prevalence of asthma, there is an increase in the number of obese patients. The results of numerous studies indicate that the asthma phenotype in combination with obesity has well-defined clinical features - a more severe course with frequent exacerbations and reduced control of the disease. The article considers the main pathogenetic mechanisms that determine the development of the asthma phenotype in combination with obesity. The influence of excess adipose tissue in the chest on respiratory mechanics, the correlation of gastroesophageal reflux disease and respiratory depression in sleep are described. It is shown that the phenotype of asthma with obesity is characterized by inflammation of adipose tissue, adipokine imbalance, insulin resistance, and disturbance of vitamin D metabolism. Gender peculiarities and genetic condition of asthma associated with obesity are considered. Understanding general mechanisms underlying the formation of asthma and obesity will undoubtedly contribute to the development of new therapeutic strategies.
About the Authors
A. A. Uksumenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
M. V. Antonyuk
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
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92. Yamamoto R., Ueki S., Moritoki Y., Kobayashi Y., Oyamada H., Konno Y., Tamaki M., Itoga M., Takeda M., Ito W., Chihara J. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implication in allergic inflammation. J Asthma. 2013; 50(8):828-835.doi: 10.3109/02770903.2013.816725
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Uksumenko A.A., Antonyuk M.V. PATHOGENETIC ASPECTS OF THE PHENOTYPE OF BRONCHIAL ASTHMA ASSOCIATED WITH OBESITY. Bulletin Physiology and Pathology of Respiration. 2019;(71):112-119. (In Russ.)
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