Current issues of non-medicated treatment of patients with bronchial asthma and obesity
https://doi.org/10.36604/1998-5029-2019-73-87-97
Abstract
The article is devoted to the use of non-drug therapy for asthma in patients with obesity. The widely used non-pharmacological methods are described in terms of their effect on the main pathogenetic links of asthma-obesity phenotype. The analysis of the effectiveness of the integrated use of natural and preformed physical factors is done. It is shown that non-drug technologies can prevent the progression of diseases and improve the quality of life for patients with asthma and obesity. The presented data have demonstrated the need to develop new combined methods of applying basic therapy and non-drug methods, innovative physiotherapy technologies.
About the Authors
N. S. YubitskayaRussian Federation
Natalia S. Yubitskaya - MD, PhD (Med.), Staff Scientist of Laboratory of Rehabilitation Treatment.
73g Russkaya Str., Vladivostok, 690105
M. V. Antonyuk
Russian Federation
Marina V. Antonyuk - MD, PhD, D.Sc. (Med.), Professor, Head of Laboratory of Rehabilitation Treatment.
73g Russkaya Str., Vladivostok, 690105
References
1. Airapetova N.S., Kulikova O.V., Antonovich I.V., Uianaeva A.I., Ksenofontova I.V, Gosn L.D., Tarasova L.Yu., Derevnina N.A. Dynamics of a clinical and functional condition of patients with obstructive diseases at application of ra-donic bathtubs. Problems of Balneology, Physiotherapy, and Exercise Therapy = Voprosy kurortologii, fizioterapii i le-chebnoi fizicheskoi kul'tury 2016; 93(2-2):28 (in Russian).
2. Airapetova N.S., Nitchenko O.V., Kulikova O.V, Antonovich I.V., Uianaeva A.I. On the usefulness of including general biolong baths in the combined therapeutic and rehabiliatative treatment of the patients presenting with obstructive diseases of the respiratory organs. Problems of Balneology, Physiotherapy, and Exercise Therapy = Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul’tury 2014; 91(4): 7-12 (in Russian).
3. Antipova I.I., Zaripova T.N., Smirnova I.N. Optimization of balneotherapy of patients with asthma in combination with arterial hypertension. Evraziyskiy soyuz uchenykh 2015; 2-4 (11):118-119 (in Russian).
4. Antonyuk M.V., Gvozdenko T.A., Geltser B.I., Yurenko A.V., Mineeva E.E., Khodosova K.K. To the question of optimizing sanatorium-spa treatment of bronchial asthma in combination with obesity. Vestnikfizioterapii i kurortologii 2018; 24 (3):37-41 (in Russian).
5. Antonyuk M.V., Knyshova V.V., Tsareva U.V The effectiveness of health resort treatment of patietns with bronchial asthma associated with obesity. In: Proceedings of the IX International Scientific Conference «Systems Analysis in Medicine». Blagoveshchensk; 2015:110-115 (in Russian).
6. Antonyuk M.V., Tsareva U.V., Vitkina T.I., Khodosova K.K. State of the immune status in patients with bronchial asthma and obesity. Bulleten' fiziologii i patologii dyhania = Bulletin Physiology and Pathology of Respiration 2015; 55:15-20 (in Russian).
7. Antonyuk M.V., Tsareva U.V, Vitkina T.I., Khodosova K.K., Demeev Ya.A., Skachkov O.A. Cranial electrotherapy stimulation in combination with antioxidant balneotherapy in the treatment of patients with bronchial asthma associated with obesity. Voyenno-meditsinskiy zhurnal 2016; 337(9):57-59 (in Russian).
8. Antonyuk M.V, Tsareva U.V!, Khodosova K.K., Geltser B.I. Influence balneotherapy on the status of the system lipid peroxidation - antioxidant protection in patients with bronchial asthma in combination with obesity. Meditsina Kyr-gyzstana 2017; 1(4):34-38 (in Russian).
9. Astaf’yeva N.G., Gamova I.V, Udovichenko E.N., Perfilova I.A. Obesity and bronchial asthma. Lechashchiy Vrach 2014; 4:8-12 (in Russian).
10. Boykov VA., Kobyakova O.S., Deyev I.A., Kulikov Y.S., Starovoytova Y.A. State of respiratory function in patients with obesity. Bulletin of Siberian Medicine 2013; 12(1):86-92 (in Russian). https://doi.org/10.20538/1682-0363-2013-1-86-92
11. Vasileva L.V, Orlova E.V, Zolotareva M.A. Mexidol in asthma treatment. Farmateka 2007; 17:80-86 (in Russian). https ://pharmateca. ru/ru/archive/article/7001
12. World Health Organization. Obesity and overweight. 2013. Fact sheet 311. Available at: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
13. Dudchenko L.Sh., Ezhov VV, Kovalchuk S.I., Kozhemyachenko E.N., Belyaeva S.N., Maslikova G.G. Rehabilitation of patients with bronchial asthma complicated by obesity. Kurortnaya meditsina 2018; 2:64-69 (in Russian).
14. Zubkova S.M., Bogolyubov V.M. Transcerebral electrotherapy. In: Bogolyubov VM., editor. Physical therapy and balneology (Vol.1). Moscow: Binom; 2008: 224-232 (in Russian).
15. Ignatova G.L., Makarova E.A. Asthma and obesity: clinical and pathophysiological aspects of new asthma phenotype assignment. Sovremennyye problemy nauki i obrazovaniya 2016; 4. Available at: http://science-education.ru/ru/ar-ticle/view?id=25017
16. Klyuchnikov S.O. Coenzyme Q10. Prospects of a clinical use. Consilium Medicum. Pediatriya (Prilozheniye) 2014; 3:84-88 (in Russian).
17. Klyuchnikov S.O., Gnetneva E.S. Ubiquinone (Coenzyme Q10): theory and clinical practice. Pediatria 2008; 87 (3): 103-110 (in Russian).
18. Kontorshchikova K.N., Efremenko Yu.R., Koroleva E.F. Ozonotherapy for the correction of disturbances of lipid metabolism in patients presenting with metabolic syndrome. Fizioterapiya, Bal ’neologiya i Reabilitatsiya 2011; 2:35-37 (in Russian).
19. Kytikova O.Yu. Ozonotherapy in rehabilitation of patients with chronic bronchopulmonary diseases and obesity. Health. Medical ecology. Science 2017; 4:59-63 (in Russian).
20. Lebedev V.P., Malygin A.V, Bilichenko S.V, Rogova N.V, Petrov VI. About the possibilities of using transcranial electrostimulation of protective (endorphinergic) brain mechanisms for the treatment of diabetes mellitus: experimental and clinical studies. Vestnik sovremennoy klinicheskoy meditsiny 2010; 3(Suppl.1):104-105 (in Russian).
21. Mineev V.N., Lalaeva T.M., Vasil'eva T.S. Features of leptin signaling in bronchial asthma. Vestnik of Saint Petersburg University. Medicine 2013; (1):34-44 (in Russian).
22. Provotorov VM., Filatova Yu.I. Correction of lipid peroxidation in patients with bronchial asthma using ceruloplasmin and pulsed red light. Lechashchiy vrach 2016; 3:94-95 (in Russian).
23. Savchenko V.M., Kovganko А.А., Dudchenko L.Sh., Yarosh A.M., P'yankov A.F., Koval'chuk S.S., Shubina L.P., Maslikova G.G., Belyaeva S.N. The development of pulmonology at the Research institute of physical therapy and medical climatology named after I.M.Sechenov. In: Proceedings of the scientific and practical conference "Actual issues of balneology, physiotherapy and medical rehabilitation". Yalta; 2014:16-22 (in Russian).
24. Stepanenko N.P., Kondrat’yeva E.I., Svetlik O.B., Dostovalova O.V., Alaytseva S.V. Patent 2440086 RU. Method for the rehabilitation of obese children and adolescents; published 20.01.2012 (in Russian).
25. Ponomarenko G.N., editor. Physiotherapy: National Guide. Moscow: GEOTAR-Media; 2009 (in Russian).
26. Tsareva U.V, Antonyuk M.V., Bergan VM., Lamikhina S.A. Optimization of sanatorium-resort treatment of patients with bronchial asthma associated with obesity. Problems of Balneology, Physiotherapy, and Exercise Therapy = Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury 2016; 93(2-2): 175-176 (in Russian).
27. Tsareva U.V., Antonyuk M.V., Lisenkov A.A. The use of baths "Biolong" in the spa treatment of patients with bronchial asthma with obesity. In: Proceedings of the VII Conference of Pulmonologists of Siberia and the Far East. Blagoveshchensk; 2017:203-207 (in Russian).
28. Chuchalin A.G., Aisanov Z.R., Belevskiy A.S., Bushmanov A.Y., Vasil’yeva O.S., Volkov I.K., Geppe N.A., Knyaz-heskaya N.P., Kondyurina E.G., Kolosova N.G., Mazitova N.N., Malakhov A.B., Meshcheryakova N.N., Nenasheva N.M., Revyakina V.A., Shubin I.V. Federal clinical guidelines for the diagnosis and treatment of bronchial asthma. Moscow; 2016: Available at: http://spulmo.ru/download/Asthmarec3.pdf (in Russian).
29. Shemyakina T.A., Golikova Ye.V., Kondratieva Ye.I., Plachkova YA.A., Stepanenko N.I. Possibilities of respiratory exercises in medical rehabilitation of preschool age children with respiratory organs pathology. Problems of Balneology, Physiotherapy, and Exercise Therapy = Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul’tury 2008; 2:31-33 (in Russian).
30. Shilov A.M., Mel'nik M.V, Osiya A.O., Sviridova A.Yu, Gryaznov D.A. The role of magnesium deficiency in the pathogenesis of the metabolic syndrome. Russkiy meditsinskiy zhurnal 2008; 16(21):1439-1444 (in Russian).
31. Yubitskaya N.S., Knyshova V.V., Kozlovskaya E.P. Influence of the sea urchin extract on the immune status in the bronchopulmonary pathology. Health. Medical ecology. Science 2017; 4:130-132 (in Russian).
32. Yashchuk A.V., Ezhov S.N., Gvozdenko T.A. Pathogenetic substantiation of kinesitherapy at the stage of longterm rehabilitation of children with bronchial asthma. Bulleten' fiziologii i patologii dyhania = Bulletin Physiology and Pathology of Respiration 2014; 54:42-47 (in Russian).
33. Adeniyi F.B., Young T. Weight loss interventions for chronic asthma. Cochrane Database Syst. Rev. 2012; 7: CD009339. doi: 10.1002/14651858.CD009339.pub2.
34. Alemzadeh R., Kichler J., Babar G., Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008; 57(2): 183—191. doi: 10.1016/j.metabol.2007.08.023
35. Bhakta N.R., Woodruff P.G. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol. Rev. 2011; 242(1):220-232. doi: 10.1111/j.1600-065X.2011.01032.x
36. Boulet L. P., Turcotte H., Martin J., Poirier P. Effect of bariatric surgery on airway response and lung function in obese subjects with asthma. Respir. Med. 2012; 106(5):651-660. doi: 10.1016/j.rmed.2011.12.012
37. Brehm J.M., Acosta-Perez E., Klei L., Roeder K., Barmada M., Boutaoui N., Forno E., Kelly R., Paul K., Sylvia J., Litonjua A.A., Cabana M., Alvarez M., Colon-Semidey A., Canino G., Celedon J.C. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am. J. Respir. Crit. Care Med. 2012; 186(2):140-146. doi: 10.1164/rccm.201203-0431OC
38. Coffey M.J., Torretti B., Baptist A. Relationship between cysteinyl leukotrienes and nitric oxide in the pathogenesis of asthma in obesity. J. Allergy Asthma 2017; 4:1-8. http://dx.doi.org/10.7243/2054-9873-4-1
39. Da Silva P.L., De Mello M.T., Cheik N.C., Sanches P.L., Correia F.A., de Piano A., Corgosinho F.C., Campos R.M., do Nascimento C.M., Oyama L.M., Tock L., Tufik S., Damaso A.R. Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents. Pediatr. Pulmonol. 2012; 47(1):8-17. doi: 10.1002/ppul.21502
40. de Aquino A.E. Jr., de Castro C.A., Ana da Silva K., Carbinatto .FM., Anibal F.F., Duarte A.C.GO, Bagnato V.S., Parizotto N.A. Low-level laser therapy promotes decrease in inflammatory process in obesetrained rats. J. Community Med. Health Educ. 2016; 6:414-414. doi: 10.4172/2161-0711.1000414
41. Deqiu Z., Kang L., Jiali Y., Baolin L., Gaolin L. Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium. Biochimie 2011; 93(3): 506-512. doi: 10.1016/j.biochi.2010.11.002
42. Dixon A.E., Pratley R.E., Forgione P.M., Kaminsky D.A., Whittaker-Leclair L.A., Griffes L.A., Garudathri J., Raymond D., Poynter M.E., Bunn J.Y., Irvin C.G. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J. Allergy. Clin. Immunol. 2011; 128(3):508-515. doi: 10.1016/jjaci.2011.06.009
43. Eneli I.U., Skybo T., Camargo C.A.Jr. Weight loss and asthma: a systematic review. Thorax 2008; 63(8):671-676. doi: 10.1136/thx.2007.086470
44. Flaherman V, Rutherford G. W. A meta-analysis of the effect of high weight on asthma. Arch. Dis. Child. 2006; 91 (4):334-339. doi: 10.1136/adc.2005.080390
45. Ford E.S. The epidemiology of obesity and asthma. J. Allergy Clin. Immunol. 2005; 115(5):897-909. doi: 10.1016/j.jaci.2004.11.050
46. Giouleka P., Papatheodorou G., Lyberopoulos P., Karakatsani A., Alchanatis M., Roussos C., Papiris S., Loukides S. Body mass index is associated w it h leukotriene inflammation in asthmatics. Eur. J. Clin. Invest. 2011; 41(1):30-38. doi: 10.1111/j.1365-2362.2010.02371.x
47. Global strategy for asthma management and prevention (Update 2016): Available at: https://ginasthma.org/wp-content/uploads/2016/04/GINA-2016-main-report_tracked.pdf
48. Guh D.P., Zhang W., Bansback N., Amarsi Z., Birmingham C.L., Anis A.H. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9:88. doi: 10.1186/1471-2458-9-88
49. Hakala K., Stenius-Aarniala B., Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest 2000; 118(5): 1315-1321.
50. Hermsdorff H.H.M., Zulet M.A., Puchau B., Martinez J.A. Central adiposity rather than total adiposity measurements are specifically involved in the inflammatory status from healthy young adults. Inflammation 2011; 34(3):161-170. doi: 10.1007/s10753-010-9219-y.65
51. Hom J., Morley E.J., Sasso P., Sinert R. Body mass index and pediatric asthma outcomes. Pediatr. Emerg. Care 2009; 25(9):569-571. doi: 10.1097/PEC.0b013e3181b4f639
52. Kempuraj D., Madhappan B., Christodoulou S., Boucher W., Cao J., Papadopoulou N., Cetrulo C.L., Theoharides T. C. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br. J. Pharmacol. 2005; 145(7):934-944. doi: 10.1038/sj.bjp.0706246
53. Kimata M., Schchijo M., Miura T., Serizawa I., Inagaki N., Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin. Exp. Allergy 2000; 30(4):501-508.
54. Mannino D.M., Mott J., Ferdinands J.M.; Camargo C.A., Friedman M., Greves H.M., Redd S.C. Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY). Int. J. Obes. (Lond). 2006; 30(1):6-13. doi: 10.1038/sj.ijo.0803145
55. Middleton E.Jr., Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol. Rev. 2000; 52(4):673-751.
56. Novosad S., Khan S., Wolfe B., Khan A. Role of obesity in asthma control, the obesity-asthma phenotype. J. Allergy (Cairo) 2013; 2013:538642.
57. Peters-Golden M., Swern A., Bird S.S., Hustad C. M., Grant E., Edelman J.M. Influence of bodymass index on the response to asthma controller agents. Eur. Respir. J. 2006; 27(3):495-503. doi: 10.1183/09031936.06.00077205
58. Pradeepan S., Garrison G., Dixon A.E. Obesity in asthma: approaches to treatment. Curr. Allergy Asthma Rep. 2013; 13(5):434-442. doi: 10.1007/s11882-013-0354-z
59. Schatz M., Hsu J.W., Zeiger R.S., Chen W., Dorenbaum A., Chipps B.E., Haselkorn T. Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma. J. Allergy Clin. Immunol. 2014; 133(6): 1549-1556. doi: 10.1016/j.jaci.2013.10.006
60. Scott H.A., Gibson P.G., Garg M.L., Pretto J.J., Morgan P.J., Callister R., Wood LG. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial. Clin. Exp. Allergy 2013; 43(1):36-49. doi: 10.1111/cea.12004
61. Sood A., Qualls C., Li R., Schuyler M., Beckett W.S., Smith L.J., Thyagarajan B., Lewis C.E., Jacobs D.R., CAR-DIA Investigators. Lean mass predicts asthma better than fat mass among females. Eur. Respir. J. 2011; 37(1):65-71. doi: 10.1183/09031936.00193709
62. Sutherland E.R., Goleva E., Jackson L.P., Stevens A.D., Leung D.Y. Vitamin D levels, lung function, and steroid response in adult asthma. Am. J. Respir. Crit. Care Med. 2010; 181 (7):699-704. doi: 10.1164/rccm.200911-1710OC
63. Telenga E. D., Tideman S. W., Kerstiens H. A., Hacken N.H., Timens W., Postma D.S., van den Berge M. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy 2012; 67(8):1060-1068. doi: 10.1111/j.1398-9995.2012.02855.x
64. Visness C.M., London S.J., Daniels J.L., Kaufman J.S., Yeatts K.B., Siega-Riz A.M., Calatroni A., Zeldin D.C. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006. J. Asthma 2010; 47(7):822-829. doi: 10.3109/02770903.2010.489388
65. Wenceslau C.F., McCarthy C.G., Szasz T., Spitler K., Goulopoulou S., Webb R.C., Working Group on DAMPs in Cardiovascular Disease. Mitochondrial damage-associated molecular patterns and vascular function. Eur. Heart J. 2014; 35(18): 1172-1177. doi: 10.1093/eurheartj/ehu047
Review
For citations:
Yubitskaya N.S., Antonyuk M.V. Current issues of non-medicated treatment of patients with bronchial asthma and obesity. Bulletin Physiology and Pathology of Respiration. 2019;(73):87-97. (In Russ.) https://doi.org/10.36604/1998-5029-2019-73-87-97