BONE TISSUE CONDITION AND RISK FACTORS OF OSTEOPOROSIS IN MEN WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.36604/1998-5029-2019-74-45-52
Abstract
Aim. The article is devoted to the study of the prevalence of risk factors (RF) for osteoporosis (OP) and the features of osteopenic syndrome (OS) in males with chronic obstructive pulmonary disease (COPD). Materials and methods. The object of the study was 100 men with moderate and severe COPD, the average age was 57.3±9.13 years old, the duration of COPD was 15.9±4.5 years old, and 30 people did not have COPD of a similar age. The frequency and structure of the risk factors for OP and osteoporotic fractures were studied using the developed questionnaire, which included risk factors included in the FRAX algorithm, individual risk factors included in the one-minute test recommended by the International Fund for OP (2008) (physical activity, milk and dairy use products, time spent in the sun) and additional questions (intensity and duration of smoking). Bone mineral density (BMD) was determined by double X-ray absorptiometry (DXA) on a LUNAR 8743 densitometer (GE Medical Systems Lunar, USA). The results were evaluated by the T- and Z-criteria in standard deviations from the peak bone mass (CD), according to the recommendations of WHO (1994). Results. In men with COPD, OS was detected in 66% of cases, OP was diagnosed in 36% patients, osteopenia in 30% patients. Only osteopenia occurred in the control group – in 10% of cases (p <0.001). The average values of the T- and Zcriteria in patients with COPD according to DRA fit into the category of severe osteopenia, amounting to -1.86±0.14 SD and -1.92±0.16 SD, respectively. It was found that the profile of behavioral risk factors for OP in men with COPD significantly differed from the profile of the control group in terms of the frequency of active smokers (p<0.01), physical inactivity (p<0.001), inadequate consumption of milk and dairy products without calcium replacement (p< 0.01). Such a risk factor as insufficient exposure to the sun (less than 10 minutes per day) without vitamin D substitution was detected only in the group of patients with COPD in 32% of cases (p<0.001). A significant proportion of patients with COPD (86%) had 2 or more risk factors for OP at the same time. Such modifiable factors as a hereditary history and weight loss were detected only in the group of patients: in 3 and 6% of cases, respectively. Correlation analysis showed a negative relationship between the T-criterion of the lumbar spine (r = -0.23; p <0.05) and the smoker's index (r = -0.63; p<0.001). It was determined that the absolute risk of the main typical fractures associated with OP was 1.8 times higher than in those without COPD (p <0.01).
About the Authors
Yu. Yu. Shchegortsova
Amur State Medical Academy
Russian Federation
Russian Federation
MD, Postgraduate Student of Department of Faculty and Polyclinic Therapy
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
V. I. Pavlenko
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD, D.Sc. (Med.), Professor of Department of Faculty and Polyclinic Therapy
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
S. V. Naryshkina
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD, D.Sc. (Med.), Professor of Department of Faculty and Polyclinic Therapy
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
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For citations:
Shchegortsova Yu.Yu., Pavlenko V.I., Naryshkina S.V. BONE TISSUE CONDITION AND RISK FACTORS OF OSTEOPOROSIS IN MEN WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Bulletin Physiology and Pathology of Respiration. 2019;(74):45-52. (In Russ.) https://doi.org/10.36604/1998-5029-2019-74-45-52
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