ANALYSIS OF THE EFFECTIVENESS OF THE ANTIOXIDANT SYSTEM IN ADAPTOGENIC NUTRITION AND GENERAL COOLING OF THE ORGANISM
https://doi.org/10.36604/1998-5029-2019-74-98-103
Abstract
Aim. The analysis of effectiveness of antioxidant system of blood under adaptogenic nutrition and overall cold influence of rat’s organism was conducted in experimental conditions. Materials and methods. The rats were divided into five groups each having ten individuals: first group – intact animals were put in standard conditions of vivarium; second group – controlling, where the animals went through cold influence (every day in the morning the animals were put for three hours in climate camera within temperature -15ºС with humidity 50%); the third, fourth and fifth groups – experimental animals were fed before the exposure to climate camera with biologically active substances of Hypericum perforatum and Rhodiola rosea in the dosage of 30 mg/kg, 150 mg/kg, 300 mg/kg, respectively. Results. It was identified that cold influence reduces the level and components’ activity of antioxidant system of blood of experimental animals in different scope during all days of experiment. The introduction of phytocombination from Hypericum perforatum and Rhodiola rosea at a dose of 150-300 mg/kg in the food of animals exposed to low temperatures restores the concentration of ceruloplasmin in the blood of rats by 37.4-53.2%; significantly (29.9-35.2%) increases the content of vitamin E in relation to the control data; at the end of the fourth week of the experiment, the activity of tocopherol significantly exceeded the initial level by 10.9%, amounting to 32.8±1.0 mcg/ml; restores the level of catalase to 23.9-25.8% in comparison with control values and exceeds data of intact group of animals by 9.8%; on all days of the experiment, it helps to restore the content of glucose-6-phosphate dehydrogenase, increasing the accumulation of this enzyme by 4.6 and 5.9%, respectively, by the third and fourth week of the study. Conclusion. Feeding experimental animals a complex of biologically active substances from Hypericum perforatum and Rhodiola rosea at a dose of 150-300 mg/kg had a regulatory effect on the content of ceruloplasmin, catalase, glucose-6-phosphate dehydrogenase and tocopherol in the blood of rats during prolonged cold exposure.
About the Authors
N. V. Korshunova
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD, D.Sc. (Med.), Professor, Head of the Department of General Hygiene
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
E. A. Litovchenko
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD (Med.), Assistant of the Department of General Hygiene
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
E. Yu. Nedostupova
Medical Care Unit of the Ministry of Internal Affairs of the Russian Federation in the Amur Region
Russian Federation
Russian Federation
MD, Deputy Head of the Center of State Sanitary and Epidemiological Surveillance
23 Pionerskaya Str., Blagoveshchensk, 675000, Russian Federation
O. V. Yurechko
Blagoveshchensk State Pedagogical University
Russian Federation
Russian Federation
PhD (Pedagogy), Associate Professor of the Department of Theory of Methods of Physical Culture, Life Safety and Health
104 Lenina Str., Blagoveshchensk, 675000, Russian Federation
O. A. Gnitjuk
Medical and Sanitary Unit number 28 of the Federal Penitentiary Service
Russian Federation
Russian Federation
MD, Senior Epidemiologist
2 Oktyabrʹskaya Str., Blagoveshchensk, 675000, Russian Federation
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Review
For citations:
Korshunova N.V., Litovchenko E.A., Nedostupova E.Yu., Yurechko O.V., Gnitjuk O.A. ANALYSIS OF THE EFFECTIVENESS OF THE ANTIOXIDANT SYSTEM IN ADAPTOGENIC NUTRITION AND GENERAL COOLING OF THE ORGANISM. Bulletin Physiology and Pathology of Respiration. 2019;(74):98-103. (In Russ.) https://doi.org/10.36604/1998-5029-2019-74-98-103
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