RESULTS OF STUDY OF PRO- AND ANTIOXIDANT SYSTEM PARAMETERS IN CHILDREN WITH EPILEPSY
https://doi.org/10.36604/1998-5029-2019-74-104-110
Abstract
Introduction. The use of antiepileptic drugs causes an increase in the formation of free radicals and a
change in antioxidant status. As a result, effectiveness decreases or functional tolerance to anticonvulsants develops, and side effects are observed. Aim. To study the parameters of pro-and antioxidant system in epilepsy monotherapy in children. Materials and methods. On the basis of the Amur Regional Children's Clinical Hospital there conducted a controlled randomized open study of parameters of pro- and antioxidant system in children with epilepsy. The patients were randomized into 2 groups and each of them had 15 children: the group 1 where patients daily orally took carbamazepine at a average therapeutic dose of 500 mg; the group 2, patients daily orally took valproic acid at a dose of 25 mg/kg. The control group consisted of 15 healthy children, comparable by sex and age. Antioxidant status was evaluated by the levels of lipid hydroperoxides, conjugated dienes, and malondialdehyde and by the activity of the main components of the antioxidant system (ceruloplasmin, vitamin E, catalase) in the blood of patients. Results. The administration of carbamazepine to patients significantly increased the plasma levels of lipid hydroperoxides by 22%, conjugated dienes by 23%, and malondialdehyde by 33% compared with the children in the control group. The analysis of the effect of carbamazepine on the activity of the antioxidant system components revealed that the blood concentrations of ceruloplasmin, vitamin E and catalase were 33%, 26% and 16%, respectively, lower than those in the control group. The administration of valproic acid to patients significantly increased the plasma levels of lipid hydroperoxides by 21%, conjugated dienes by 28%, and malondialdehyde by 33% compared with the children in the control group. The analysis of the effect of valproic acid on the
activity of the antioxidant system components established that the blood concentrations of ceruloplasmin, vitamin E and catalase were 35%, 18% and 17%, respectively, lower than those in the control group. Conclusion. The incorporation of antioxidants into the treatment of children with epilepsy should be considered pathogenetically justified, clinically reasonable, and promising.
change in antioxidant status. As a result, effectiveness decreases or functional tolerance to anticonvulsants develops, and side effects are observed. Aim. To study the parameters of pro-and antioxidant system in epilepsy monotherapy in children. Materials and methods. On the basis of the Amur Regional Children's Clinical Hospital there conducted a controlled randomized open study of parameters of pro- and antioxidant system in children with epilepsy. The patients were randomized into 2 groups and each of them had 15 children: the group 1 where patients daily orally took carbamazepine at a average therapeutic dose of 500 mg; the group 2, patients daily orally took valproic acid at a dose of 25 mg/kg. The control group consisted of 15 healthy children, comparable by sex and age. Antioxidant status was evaluated by the levels of lipid hydroperoxides, conjugated dienes, and malondialdehyde and by the activity of the main components of the antioxidant system (ceruloplasmin, vitamin E, catalase) in the blood of patients. Results. The administration of carbamazepine to patients significantly increased the plasma levels of lipid hydroperoxides by 22%, conjugated dienes by 23%, and malondialdehyde by 33% compared with the children in the control group. The analysis of the effect of carbamazepine on the activity of the antioxidant system components revealed that the blood concentrations of ceruloplasmin, vitamin E and catalase were 33%, 26% and 16%, respectively, lower than those in the control group. The administration of valproic acid to patients significantly increased the plasma levels of lipid hydroperoxides by 21%, conjugated dienes by 28%, and malondialdehyde by 33% compared with the children in the control group. The analysis of the effect of valproic acid on the
activity of the antioxidant system components established that the blood concentrations of ceruloplasmin, vitamin E and catalase were 35%, 18% and 17%, respectively, lower than those in the control group. Conclusion. The incorporation of antioxidants into the treatment of children with epilepsy should be considered pathogenetically justified, clinically reasonable, and promising.
About the Authors
L. A. Nosal'
Amur State Medical Academy;
Amur Regional Children's Clinical Hospital
Russian Federation
Russian Federation
MD, Postgraduate Student of Department of Hospital Therapy with Pharmacology Course; Neurologist of the Children's Neuropsychiatric Department
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
108 Oktyabr/skaya Str., 675005, Blagoveshchensk, Russian Federation
N. S. Simonova
Amur State Medical Academy
Russian Federation
Russian Federation
PhD, D.Sc. (Biol.), Professor of Department of Hospital Therapy with Pharmacology Course
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
V. A. Dorovskikh
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD, D.Sc. (Med.), Professor of Department of Hospital Therapy with Pharmacology Course
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
R. A. Аnokhina
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD (Med.), Senior Lecturer of Department of Hospital Therapy with Pharmacology Course
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
M. M. Shtarberg
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD (Med.), Senior Laboratory Assistant of Department of Chemistry
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
T. V. Zabolotskikh
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD, D.Sc. (Med.), Professor, Rector
95 Gor'kogo Str., Blagoveshchensk, 675000, Russian Federation
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Review
For citations:
Nosal' L.A., Simonova N.S., Dorovskikh V.A., Аnokhina R.A., Shtarberg M.M., Zabolotskikh T.V. RESULTS OF STUDY OF PRO- AND ANTIOXIDANT SYSTEM PARAMETERS IN CHILDREN WITH EPILEPSY. Bulletin Physiology and Pathology of Respiration. 2019;(74):104-110. (In Russ.) https://doi.org/10.36604/1998-5029-2019-74-104-110
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