MODERN CONCEPTS OF THE ROLE OF TRANSIENT RECEPTOR POTENTIAL CHANNELS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATHOGENESIS (REVIEW)
https://doi.org/10.36604/1998-5029-2019-74-119-130
Abstract
The article analyzes the results of recent studies, forming the modern concept of the pathogenesis of chronic obstructive pulmonary disease (COPD) as a disease with an autoimmune component, with an emphasis on the special role of bronchial epithelium and macrophages in the organization of the primary immune response. Of great interest is the evidence of the receptor function of some transient receptor potential (TRP) channels in relation to cigarette smoke and particulate matter – the main etiological factors of COPD. It was found that these channels can be expressed on epithelium and cells of innate immunity, and can also exert a modulating effect on the course of the inflammatory reaction. At present, relatively little attention is paid to the study of the possible role of TRP channels in COPD, despite the available facts indicate their key role in this disease, especially at its initial stages. This review is aimed at systematizing the results of the studies conducted in this field.
About the Authors
I. Yu. Sugaylo
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
PhD Postgraduate student
22 Kalinina Str., Blagoveshchensk, 675000, Russian Federation
D. E. Naumov
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
MD, PhD (Med.), Head of the Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000, Russian Federation
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For citations:
Sugaylo I.Yu., Naumov D.E. MODERN CONCEPTS OF THE ROLE OF TRANSIENT RECEPTOR POTENTIAL CHANNELS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATHOGENESIS (REVIEW). Bulletin Physiology and Pathology of Respiration. 2019;(74):119-130. (In Russ.) https://doi.org/10.36604/1998-5029-2019-74-119-130
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