DYNAMICS OF CHANGES OF CONCENTRATION OF DOCOSAHEXAENOIC ACID IN PERIPHERAL BLOOD IN PREGNANCY WITH REACTIVATION OF CHRONIC CYTOMEGALOVIRUS INFECTION
https://doi.org/10.12737/article_59360ed81f4757.61165334
Abstract
The dynamics of docosahexaenoic acid in 96 pregnant women in I, II and III trimesters of gestation during the reactivation of chronic cytomegalovirus infection (CMVI) was studied by gas-liquid chromatography. The comparison group consisted of women with physiological pregnancy, comparable in age and stage of gestation with the main group. The material for research was peripheral blood (plasma and erythrocyte membrane) which was taken from the ulnar vein in the morning on an empty stomach. Heparin was used as an anticoagulant. The study found that with the reactivation of chronic CMVI (IgG antibody titer to CMV 1:1600), the content of docosahexaenoic acid in plasma of peripheral blood of pregnant women decreased in the first trimester by 31% (p<0.001), in the II trimester by 25% (p<0.001), and by 38% (p<0.001) by the end of the gestation period, in comparison with the control group. In the erythrocyte membrane, the content of this acid decreased by 29% in the first trimester (p<0.001), by 16% in the second trimester (p<0.001), and by 29% (p<0.001) in the III trimester, in comparison with the control group. The revealed dynamics of changes in the concentration of docosahexaenoic acid in pregnant women with CMVI will contribute to insufficient transfer of this acid from the mother's blood to the fetal blood through the placenta. Therefore, our studies show that the optimal balance in the blood and a sufficient dietary intake of docosahexaenoic acid is necessary for the normal maturation and functioning of a healthy body. Products containing docosahexaenoic acid should take a special place in the diet of pregnant women, as it affects the formation of the fetus. However, given that the food sources of the acids of the ω-3 family are rather limited and the ratio ω-6/ω-3 in the diet of a modern person is far from optimal, we recommend that women with reactivation of CMVI during gestation should have biologically active dietary supplements that enrich the diet with polyunsaturated fatty acids.
About the Author
N. A. Ishutina
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
References
1. Боровик Т.Э., Грибакин С.Г., Семенова Н.Н., Степанова Т.Н., Звонкова Н.Г. Длинноцепочечные полиненасыщенные жирные кислоты и их роль в детском питании. Обзор литературы. // Вопросы современной педиатрии. 2012. Т.11, №4. С.21-28. DOI:10.15690/vsp.v11i4.355
2. Ишутина Н.А. Докозагексаеновая кислота у беременных с обострением герпес-вирусной инфекции // Актуальные проблемы современной науки. 2012. Т.1, №1. С.29-31.
3. Ишутина Н.А., Дорофиенко Н.Н. Пероксидация липидов при беременности, осложненной цитомегаловирусной инфекцией // Бюллетень физиологии и патологии дыхания. 2014. Вып.54. С.66-69.
4. Катаев А.Е., Алейникова Т.Л. Эйкозаноиды и воспаление // Современная ревматология. 2016. №4. С.73-86.
5. Луценко М.Т., Андриевская И.А., Довжикова И.В., Соловьева А.С. Фетоплацентарная система при обострении герпес-вирусной инфекции во время беременности. Благовещенск, 2010. 245 с.
6. Шилина Н.М., Конь И.Я. Современные представления о физиологических и метаболических функциях полиненасыщенных жирных кислот // Вопросы детской диетологии. 2004. Т.2, №6. С.25-30.
7. Agostoni C. Role of long-chain polyunsaturated fatty acids in the first year of life // J. Pediatr. Gastroenterol. Nutr. 2008. Vol.47, Suppl.2. P.41-44.
8. Demmelmair H., Koletzko B. Importance of fatty acids in the perinatal period // World Rev. Nutr. Dietary. 2015. Vol.112. P.31-47.
9. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues // J. Biol. Chem. 1957. Vol.226, №1. Р.497-509.
10. Markides M., Gibson R.A. Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation // Am. J. Clin. Nutr. 2000. Vol.71, Suppl.1. P.307-311.
11. Smithers L.G., Gibson R.A., McPhee A., Makrides M. Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial // Am. J. Clin. Nutr. 2008. Vol.88, №4. P.1049-1056.
12. Wurtman R.J. A nutrient combination that can affect synapse formation // Nutrients. 2014. Vol.6, №4. P.1701-1710.
Review
For citations:
Ishutina N.A. DYNAMICS OF CHANGES OF CONCENTRATION OF DOCOSAHEXAENOIC ACID IN PERIPHERAL BLOOD IN PREGNANCY WITH REACTIVATION OF CHRONIC CYTOMEGALOVIRUS INFECTION. Bulletin Physiology and Pathology of Respiration. 2017;(64):60-63. (In Russ.) https://doi.org/10.12737/article_59360ed81f4757.61165334
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