PROGESTERONE METABOLISM IN PLACENTA (REVIEW)
https://doi.org/10.12737/article_5936356ad72dd1.30067788
Abstract
Current data on progesterone metabolism in placenta are presented in the article. Enzymes involved in the conversion of gestogens: aldo-keto reductases (AKR1D1, AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2), 3β- and 17β-hydroxysteroid dehydrogenases were studied. Existing opinions on their essential role in the maintenance of pregnancy were presented. The main metabolites of progesterone in placenta, namely 20α-dihydroprogesterone and 5α-dihydroprogesterone were presented. In addition, special attention was paid to other two metabolites actively studied at present: 5β-dihydroprogesterone and allopregnenolone. Their central role was emphasized: 5β-dihydroprogesterone maintains myometrium tonus at quiescent interval, and allopregnenolon is a key neuroactive steroid during the fetal life. It was concluded that further research is needed to study progesterone metabolism in placenta.
About the Authors
I. V. Dovzhikova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
M. T. Lutsenko
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
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Review
For citations:
Dovzhikova I.V., Lutsenko M.T. PROGESTERONE METABOLISM IN PLACENTA (REVIEW). Bulletin Physiology and Pathology of Respiration. 2017;(64):101-107. (In Russ.) https://doi.org/10.12737/article_5936356ad72dd1.30067788
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