CHANGES IN THE SPECTRUM OF CYTOKINES IN BLOOD SERUM IN BRONCHIAL ASTHMA PATIENTS DEPENDING ON SEVERITY AND FORM OF THE DISEASE
Abstract
The paper deals with the research on changes in the spectrum of pro- and antiinflammatory cytokines in bronchial asthma patients as related to the severity of the disease. 115 patients have been examined with 41 patients having disease of medium severity, 42 having severe forms of the disease, and 32 with steroid-dependant forms. Along with that 45 of the patients were found to have non-allergic bronchial asthma, while 70 had a mixed bronchial asthma form. All the patients were tested for proinflammatory (IL-1β, IL-6, IL-8, TNF-α) and antiinflammatory (IL-4) cytokines. As a result, it was found out that the level of proinflammatory cytokines tends to increase: IL-1β in 1.2-3.2 times, IL-6 - 2.1-2.8 times and IL-8 in 1.6-3.4 times in accord with bronchial asthma severity, which can be attributed to intensification of inflammatory process activity along with compensatory growth of antiinflammatory cytokine levels in 2.1-18.6 times. The research shows that inflammatory process develops more actively with non-allergic bronchial asthma patients as compared to the ones having a mixed bronchial asthma form, which is proved by the growth in proinflammatory cytokines rates. It has been found that in patients with severe forms of steroid-dependant bronchial asthma high levels of IL-8 persist not depending on the form or severity of the disease, which can result from the development of cell-producers' resistance to glucocorticoid hormones.
About the Authors
Elena L. Lazutkina
Amur State Medical Academy
Russian Federation
Russian Federation
Yurii S. Landyshev
Amur State Medical Academy
Russian Federation
Russian Federation
Dondok D. Tsyrendorzhiev
Research Institute of Clinical Immunology of Siberian Branch RAMS
Russian Federation
Russian Federation
Sergey Yu. Landyshev
Amur State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Lazutkina E.L., Landyshev Yu.S., Tsyrendorzhiev D.D., Landyshev S.Yu. CHANGES IN THE SPECTRUM OF CYTOKINES IN BLOOD SERUM IN BRONCHIAL ASTHMA PATIENTS DEPENDING ON SEVERITY AND FORM OF THE DISEASE. Bulletin Physiology and Pathology of Respiration. 2012;(43):13-18. (In Russ.)
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