THE CHANGE OF SENSITIVITY OF THE BRONCHIAL TREE TO BRONCHODILATORS IN PATIENTS WITH FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS DURING THE DAY
Abstract
The aim of the research was to study circadian rhythms of lung function in patients with fibrous-cavernous pulmonary tuberculosis, the early identification of presence and intensity of bronchial spasm in different time of the day, and determination of chronosensitivity of the bronchial tree to bronchodilators. 30 patients with fibrous-cavernous pulmonary tuberculosis were studied. The control group consisted of 15 healthy people. The studies were conducted for 2 days at 6 a.m., 12 a.m., 6 p.m. and 12 p.m. Аt 6 a.m. and 6 p.m. inhalation bronchodilatation test with salbutamol was carried out to detect bronchospasm and bronchial tree sensitivity to bronchodilator drugs. It was revealed that patients with fibrous-cavernous pulmonary tuberculosis had pathologic circadian rhythms of lung function with sudden worsening of bronchial conductance and bronchospasm initiation at evening and night time. There was also the intensification of chronosensitivity of bronchi to pharmacological influence of inhalation bronchodilators at evening and night hours, which dictates the necessity of correction of their application time.
Keywords
fibrous-cavernous pulmonary tuberculosis,
circadian rhythms,
external respiration function,
bronchial conductance,
bronchodilators
616.24.-002.17/.54:616.233-008.6-072.2«347»
About the Authors
Ol'ga A. Karakulova
Amur State Medical Academy
Russian Federation
Russian Federation
Vladimir P. Mishuk
Amur State Medical Academy
Russian Federation
Russian Federation
Vasiliy A. Bashkatov
Amur State Medical Academy
Russian Federation
Russian Federation
Tamara A. Savinova
Amur State Medical Academy
Russian Federation
Russian Federation
Svetlana A. Goryacheva
Amur State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Karakulova O.A., Mishuk V.P., Bashkatov V.A., Savinova T.A., Goryacheva S.A. THE CHANGE OF SENSITIVITY OF THE BRONCHIAL TREE TO BRONCHODILATORS IN PATIENTS WITH FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS DURING THE DAY. Bulletin Physiology and Pathology of Respiration. 2012;(43):52-55. (In Russ.)
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