LISOPHOSPHATIDILCHOLINE AND ARACHIDONIC ACID AS MARKERS OF MEMBRANODESTRUCTION AND THEIR METABOLISM AT HERPES-VIRUS INFECTION
Abstract
The contents of arachidonic acid and lisophosphatidilcholine in membranes of erythrocytes of the peripheral blood of pregnant women who suffered during gestation the exacerbation of herpes-virus infection (antibody titer IgG to virus of simple herpes-1 was 1:12800) were studied with the help of methods of thin-layer and gas chromatography. The increase of arachidonic acid (in I trimester up to 3.26±0.12%, in II trimester up to 4.59±0.72% and in III up to 5.12±0.61%) and of lisophosphatidilcholine (up to 6.30±0.94% in I trimester, 7.50±0.39% in II trimester and up to 9.90±0.58% in III trimester) was found out in membranes of erythrocytes of women with the exacerbation of herpes-virus infection. Taking into account that these lipids are mediators of a wide spectrum of cellular processes of proinflammatory character and lisophosphatidilcholine is a haemolytic poison, the excess of these lipids in the peripheral blood of pregnant women at highly toxic herpes-virus infection leads to tissue inflammation, infringement of hemostasis and can be one of the causes of anemia. Thus, it is possible to believe that at the exacerbation of herpes-virus infection in the peripheral blood of pregnant women there are toxic products accumulated and they cause the disintegration of cells including erythrocytes.
About the Authors
Nataliа A. Ishutina
Far Eastern Scientific Center of Physiology and Pathology of Respiration of Siberian Branch RAMS
Russian Federation
Russian Federation
Nikolai N. Dorofienko
Far Eastern Scientific Center of Physiology and Pathology of Respiration of Siberian Branch RAMS
Russian Federation
Russian Federation
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Review
For citations:
Ishutina N.A., Dorofienko N.N. LISOPHOSPHATIDILCHOLINE AND ARACHIDONIC ACID AS MARKERS OF MEMBRANODESTRUCTION AND THEIR METABOLISM AT HERPES-VIRUS INFECTION. Bulletin Physiology and Pathology of Respiration. 2012;(43):93-95. (In Russ.)
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