Preview

Bulletin Physiology and Pathology of Respiration

Advanced search

CHARACTERISTIC OF PALMITIC ACID EXCHANGE IN PERIPHERAL BLOOD OF PREGNANT WOMEN WITH EXACERBATION OF HERPES-VIRUS INFECTION

Abstract

The study of palmitic acid composition in peripheral blood of pregnant women who during gestation at different terms suffered from the exacerbation of chronic herpes-virus infection depending on IgG antibodies titer to virus of 1 type simple herpes was done. It is established that at activation of chronic herpes-virus infection during pregnancy there is an increase of palmitic acid in plasma (by 13% in the first trimester, by 14 % in the second trimester and by 12% in the third trimester) and in erythrocytes of peripheral blood (by 18% in the first one, by 21% in the second one and by 15% in the third one). This led to hardening of lipid bilayer of membranes, to the increase of relative microviscosity and to the decrease of fluidity influencing the transport of water and other ions. These changes were especially evident during the period when IgG antibodies titer of pregnant women was 1:12800 in the peripheral blood of pregnant women. The revealed structural disturbances of peripheral blood of pregnant women can negatively affect the forming of developing fetus and cause intrauterine hypoxia.

Keywords


618.2./3:616.523-036.65:577.125

About the Author

Nataliа A. Ishutina,
Far Eastern Scientific Center of Physiology and Pathology of Respiration of Siberian Branch RAMS
Russian Federation


References

1. Захарова И.Н., Суркова Е.Н. Роль полиненасыщенных жирных кислот в формировании здоровья детей // Педиатрия. 2009. Т.88, №6. С.84-91.

2. Изменение микровязкости мембран эритроцитов крови у беременных, инфицированных вирусом герпеса / Н.А.Ишутина [и др.] // Бюл. физиол. и патол. дыхания. 2006. Вып.23. (Приложение). С.16-17.

3. Луценко М.Т., Довжикова И.В. Роль липидов при беременности // Бюл. физиол. и патол. дыхания. 2010. Вып.36. С.7-14.

4. Сидельникова В.М. Применение омега-3 полиненасыщенных жирных кислот для профилактики и комплексного лечения тромбофилических нарушений при беременности // Рус. мед. журн. 2008. Т.16, №6. С.1-6.

5. Изменение содержания индивидуальных С16 и С18 жирных кислот в липидах сыворотки крови пациентов с гиперлипидемией при действии фибратов / В.Н.Титов [и др.] // Клин. лаб. диагностика. 2006. №4. С.3-7.

6. Carren J.P., Dubacy J.P-J. Adaptation of a micro-seale method to the micro-seale for fatty acid methyl trausestenif: cation of biological lipid extracts // Chromatography. 1978. №151. P.384-390.

7. Folch J., Lees M., Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animals tissues // J. Biol. Chem. 1957. Vol.226. P.497-509.А

8. Herrera E. Implications of dietary fatty acid during pregnancy on placental, fetal and postnatal development: a review // Placenta. 2002. №23. Suppl. A. P.9-19.

9. Springer M., Dordrecht L. Fatty acid-binding protein: fuel metabolism // Mol. Сell. Biochem. 2007. Vol.299, №1-2. P.75-84.

10. Zakharova I.N., Surkova E.N. Pediatriya 2009; 88(6): 84-91.

11. Ishutina N.A., Dorofienko N.N., Andrievskaya I.A., Dovzhikova I.V., Bolelova S.M. Bûlleten' fiziologii i patologii dyhaniyâ 2006; 23 App.:16-17.

12. Lutsenko M.T., Dovzhikova I.V. Bûlleten' fiziologii i patologii dyhaniyâ 2010; 36: 7-14.

13. Sidel'nikova V.M. Russkiy meditsinskiy zhurnal 2008; 16(6): 1-6.А

14. Titov V.N., Arapbaeva A.A., Kukharchuk V.V., Balakina M.V., Tishinin M.A., Amelyushkina V.A. Klinicheskaya laboratornaya diagnostika 2006; 4:3-7.А

15. Carren J.P., Dubacy J.P-J. Adaptation of a micro-seale method to the micro-seale for fatty acid methyl trausestenif: cation of biological lipid extracts. Chromatography 1978; 151:384-390.А

16. Folch J., Lees M., Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animals tissues. J. Biol. Chem. 1957; 226:497-509.А

17. Herrera E. Implications of dietary fatty acid during pregnancy on placental, fetal and postnatal development: a review. Placenta 2002; 23 Suppl. A:S9-S19.А

18. Springer M., Dordrecht L. Fatty acid-binding protein: fuel metabolism. Mol. Сell. Biochem. 2007; 299(1-2):75-84.А


Review

For citations:


Ishutina, N.A. CHARACTERISTIC OF PALMITIC ACID EXCHANGE IN PERIPHERAL BLOOD OF PREGNANT WOMEN WITH EXACERBATION OF HERPES-VIRUS INFECTION. Bulletin Physiology and Pathology of Respiration. 2012;(43):96-98. (In Russ.)

Views: 179


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1998-5029 (Print)